Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol

Detalhes bibliográficos
Autor(a) principal: Nunes, Sandra C. C.
Data de Publicação: 2004
Outros Autores: Eusébio, M. Ermelinda, Leitão, M. Luísa P., Redinha, J. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/5120
Resumo: Crystallization of pindolol from the melt was studied by differential scanning calorimetry (DSC) and polarized light thermomicroscopy (PLTM) in order to discriminate the polymorphic forms obtained by this method. The crystallization process originates one exothermic signal localized in two different well-defined temperature ranges. Fusion gives rise to overlapped curves, which were analysed by peak-fitting. The polymorphs were identified as the clusters formed with the values obtained for Tpeak of the component curves. Three polymorphic forms were exhibited by pindolol crystallized from the melt. Commercial pindolol presents only two of these forms.
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spelling Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-olPindololRecrystallization from meltPolymorphismCrystallization of pindolol from the melt was studied by differential scanning calorimetry (DSC) and polarized light thermomicroscopy (PLTM) in order to discriminate the polymorphic forms obtained by this method. The crystallization process originates one exothermic signal localized in two different well-defined temperature ranges. Fusion gives rise to overlapped curves, which were analysed by peak-fitting. The polymorphs were identified as the clusters formed with the values obtained for Tpeak of the component curves. Three polymorphic forms were exhibited by pindolol crystallized from the melt. Commercial pindolol presents only two of these forms.http://www.sciencedirect.com/science/article/B6T7W-4D98M6B-1/1/3afc552c8d71e8bf5c7a34b60ab208192004info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5120http://hdl.handle.net/10316/5120engInternational Journal of Pharmaceutics. 285:1-2 (2004) 13-21Nunes, Sandra C. C.Eusébio, M. ErmelindaLeitão, M. Luísa P.Redinha, J. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-02-11T18:17:37Zoai:estudogeral.uc.pt:10316/5120Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:32.395332Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol
title Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol
spellingShingle Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol
Nunes, Sandra C. C.
Pindolol
Recrystallization from melt
Polymorphism
title_short Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol
title_full Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol
title_fullStr Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol
title_full_unstemmed Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol
title_sort Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol
author Nunes, Sandra C. C.
author_facet Nunes, Sandra C. C.
Eusébio, M. Ermelinda
Leitão, M. Luísa P.
Redinha, J. S.
author_role author
author2 Eusébio, M. Ermelinda
Leitão, M. Luísa P.
Redinha, J. S.
author2_role author
author
author
dc.contributor.author.fl_str_mv Nunes, Sandra C. C.
Eusébio, M. Ermelinda
Leitão, M. Luísa P.
Redinha, J. S.
dc.subject.por.fl_str_mv Pindolol
Recrystallization from melt
Polymorphism
topic Pindolol
Recrystallization from melt
Polymorphism
description Crystallization of pindolol from the melt was studied by differential scanning calorimetry (DSC) and polarized light thermomicroscopy (PLTM) in order to discriminate the polymorphic forms obtained by this method. The crystallization process originates one exothermic signal localized in two different well-defined temperature ranges. Fusion gives rise to overlapped curves, which were analysed by peak-fitting. The polymorphs were identified as the clusters formed with the values obtained for Tpeak of the component curves. Three polymorphic forms were exhibited by pindolol crystallized from the melt. Commercial pindolol presents only two of these forms.
publishDate 2004
dc.date.none.fl_str_mv 2004
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/5120
http://hdl.handle.net/10316/5120
url http://hdl.handle.net/10316/5120
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Pharmaceutics. 285:1-2 (2004) 13-21
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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