Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/34559 |
Resumo: | Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fi llers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specifi c degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fi bers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specifi c biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. |
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Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a reviewBone Tissue EngineeringCalcium phosphatesnanocompositesnatural polymersregenerative medicineScience & TechnologyTissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fi llers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specifi c degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fi bers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specifi c biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. The research leading to this work has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no REGPOT-CT2012-316331-POLARIS, and from QREN (ON.2 - NORTE-01-0124-FEDER-000016) cofinanced by North Portugal Regional Operational Program (ON.2 - O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF).WileyUniversidade do MinhoPina, S.Oliveira, J. M.Reis, R. L.2015-012015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/34559engPina S., Oliveira J. M., Reis R. L. Natural-based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review, Advanced Materials, Vol. 27, Issue 7, pp. 1143-1169, doi:10.1002/adma.201403354, 20150935-964810.1002/adma.20140335425580589http://onlinelibrary.wiley.com/doi/10.1002/adma.201403354/abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:36:57Zoai:repositorium.sdum.uminho.pt:1822/34559Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:33:09.195420Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review |
title |
Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review |
spellingShingle |
Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review Pina, S. Bone Tissue Engineering Calcium phosphates nanocomposites natural polymers regenerative medicine Science & Technology |
title_short |
Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review |
title_full |
Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review |
title_fullStr |
Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review |
title_full_unstemmed |
Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review |
title_sort |
Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review |
author |
Pina, S. |
author_facet |
Pina, S. Oliveira, J. M. Reis, R. L. |
author_role |
author |
author2 |
Oliveira, J. M. Reis, R. L. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pina, S. Oliveira, J. M. Reis, R. L. |
dc.subject.por.fl_str_mv |
Bone Tissue Engineering Calcium phosphates nanocomposites natural polymers regenerative medicine Science & Technology |
topic |
Bone Tissue Engineering Calcium phosphates nanocomposites natural polymers regenerative medicine Science & Technology |
description |
Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fi llers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specifi c degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fi bers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specifi c biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/34559 |
url |
http://hdl.handle.net/1822/34559 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pina S., Oliveira J. M., Reis R. L. Natural-based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review, Advanced Materials, Vol. 27, Issue 7, pp. 1143-1169, doi:10.1002/adma.201403354, 2015 0935-9648 10.1002/adma.201403354 25580589 http://onlinelibrary.wiley.com/doi/10.1002/adma.201403354/abstract |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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