Focal Malignant Liver Lesions: Diagnosis by Dynamic Incremental CT, Early Phase

• Autor(a) principal: Marques, RM
• Data de Publicação: 1996
• Outros Autores: Mendonça, P, Cordeiro, A, Monteiro, T, Vilela, J, Almeida, F
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.17/1254
• topic: Angiomatose; Intervalos de Confiança; Meios de Contraste; Diagnóstico Diferencial; Estudos de Follow-Up; Injecções Intravenosas; Doenças do Fígado; Neoplasias Hepáticas; Estudos Prospectivos; Curva ROC; Intensificação de Imagem Radiográfica; Sensibilidade e Especificidade; Tomografia Computorizada

The purpose of our study was to evaluate the accuracy of dynamic incremental bolus-enhanced conventional CT (DICT) with intravenous contrast administration, early phase, in the diagnosis of malignancy of focal liver lesions. A total of 122 lesions were selected in 74 patients considering the following criteria: lesion diameter 10 mm or more, number of lesions less than six per study, except in multiple angiomatosis and the existence of a valid criteria of definitive diagnosis. Lesions were categorized into seven levels of diagnostic confidence of malignancy compared with the definitive diagnosis for acquisition of a receiver-operator-characteristic (ROC) curve analysis and to determine the sensitivity and specificity of the technique. Forty-six and 70 lesions were correctly diagnosed as malignant and benign, respectively; there were 2 false-positive and 4 false-negative diagnoses of malignancy and the sensitivity and specificity obtained were 92 and 97%. The DICT early phase was confirmed as a highly accurate method in the characterization and diagnosis of malignancy of focal liver lesions, requiring an optimal technical performance and judicious analysis of existing semiological data.