Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/107074 https://doi.org/10.1167/iovs.18-26487 |
Resumo: | PURPOSE. Structural retinal microvascular changes have been identified as risk markers of diabetic retinopathy (DR). In order to estimate the retinal response of neuroprotective eye drops, we aimed to evaluate the effect of topical retinal neuroprotection on retinal microvascular changes in early DR. METHODS. Patients with type 2 diabetes with no or early DR were randomized 1:1:1 to topical treatment with placebo, brimonidine, or somatostatin in a 96-week prospective, phase II to III, European multicenter trial. Retinal vascular calibers were measured semiautomatically in digital fundus images by certified graders at baseline and follow-up and summarized as central retinal arteriolar and venular equivalent (CRAE and CRVE). RESULTS. Of 449 patients originally included, 297 completed the study with gradable retinal images. Median age and duration of diabetes was 64.5 and 9.9 years, and 65.7% were male. At baseline, Early Treatment Diabetic Retinopathy Study levels were 10 (no DR, 42.8%), 20 (minimal DR, 28.3%), and 35 (mild DR, 29.0%), and CRAE and CRVE did not differ between groups. As opposed to patients with no or minimal DR at baseline, patients with mild DR in the active groups developed a larger retinal arteriolar (brimonidine: þ6.2 lm, P ¼ 0.006; somatostatin: þ7.2 lm, P ¼ 0.006) and venular (brimonidine: þ13.9 lm, P ¼ 0.01; somatostatin: þ14.3 lm, P ¼ 0.0001) caliber in contrast to those in the placebo group. CONCLUSIONS. Topical treatment with brimonidine and somatostatin causes retinal arteriolar and venular dilation in patients with type 2 diabetes and preexisting early DR. Upcoming studies should elaborate on the potential of these findings in arresting early DR. |
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Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDORdiabetic retinopathytopicalretinal vasculaturebrimonidinesomatostatinAdultAgedDiabetes Mellitus, Type 2Diabetic RetinopathyFemaleHumansMaleMiddle AgedProspective StudiesRetinal VesselsAdrenergic alpha-2 Receptor AgonistsBrimonidine TartrateNeuroprotective AgentsSomatostatinPURPOSE. Structural retinal microvascular changes have been identified as risk markers of diabetic retinopathy (DR). In order to estimate the retinal response of neuroprotective eye drops, we aimed to evaluate the effect of topical retinal neuroprotection on retinal microvascular changes in early DR. METHODS. Patients with type 2 diabetes with no or early DR were randomized 1:1:1 to topical treatment with placebo, brimonidine, or somatostatin in a 96-week prospective, phase II to III, European multicenter trial. Retinal vascular calibers were measured semiautomatically in digital fundus images by certified graders at baseline and follow-up and summarized as central retinal arteriolar and venular equivalent (CRAE and CRVE). RESULTS. Of 449 patients originally included, 297 completed the study with gradable retinal images. Median age and duration of diabetes was 64.5 and 9.9 years, and 65.7% were male. At baseline, Early Treatment Diabetic Retinopathy Study levels were 10 (no DR, 42.8%), 20 (minimal DR, 28.3%), and 35 (mild DR, 29.0%), and CRAE and CRVE did not differ between groups. As opposed to patients with no or minimal DR at baseline, patients with mild DR in the active groups developed a larger retinal arteriolar (brimonidine: þ6.2 lm, P ¼ 0.006; somatostatin: þ7.2 lm, P ¼ 0.006) and venular (brimonidine: þ13.9 lm, P ¼ 0.01; somatostatin: þ14.3 lm, P ¼ 0.0001) caliber in contrast to those in the placebo group. CONCLUSIONS. Topical treatment with brimonidine and somatostatin causes retinal arteriolar and venular dilation in patients with type 2 diabetes and preexisting early DR. Upcoming studies should elaborate on the potential of these findings in arresting early DR.Association for Research in Vision and Ophthalmology2019-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107074http://hdl.handle.net/10316/107074https://doi.org/10.1167/iovs.18-26487eng1552-5783Grauslund, JakobFrydkjaer-Olsen, UlrikPeto, TundeFernández-Carneado, JimenaPonsati, BertaHernández, CristinaCunha-Vaz, JoséSimó, Rafaelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-05-11T10:15:47Zoai:estudogeral.uc.pt:10316/107074Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:26.900431Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR |
title |
Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR |
spellingShingle |
Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR Grauslund, Jakob diabetic retinopathy topical retinal vasculature brimonidine somatostatin Adult Aged Diabetes Mellitus, Type 2 Diabetic Retinopathy Female Humans Male Middle Aged Prospective Studies Retinal Vessels Adrenergic alpha-2 Receptor Agonists Brimonidine Tartrate Neuroprotective Agents Somatostatin |
title_short |
Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR |
title_full |
Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR |
title_fullStr |
Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR |
title_full_unstemmed |
Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR |
title_sort |
Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR |
author |
Grauslund, Jakob |
author_facet |
Grauslund, Jakob Frydkjaer-Olsen, Ulrik Peto, Tunde Fernández-Carneado, Jimena Ponsati, Berta Hernández, Cristina Cunha-Vaz, José Simó, Rafael |
author_role |
author |
author2 |
Frydkjaer-Olsen, Ulrik Peto, Tunde Fernández-Carneado, Jimena Ponsati, Berta Hernández, Cristina Cunha-Vaz, José Simó, Rafael |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Grauslund, Jakob Frydkjaer-Olsen, Ulrik Peto, Tunde Fernández-Carneado, Jimena Ponsati, Berta Hernández, Cristina Cunha-Vaz, José Simó, Rafael |
dc.subject.por.fl_str_mv |
diabetic retinopathy topical retinal vasculature brimonidine somatostatin Adult Aged Diabetes Mellitus, Type 2 Diabetic Retinopathy Female Humans Male Middle Aged Prospective Studies Retinal Vessels Adrenergic alpha-2 Receptor Agonists Brimonidine Tartrate Neuroprotective Agents Somatostatin |
topic |
diabetic retinopathy topical retinal vasculature brimonidine somatostatin Adult Aged Diabetes Mellitus, Type 2 Diabetic Retinopathy Female Humans Male Middle Aged Prospective Studies Retinal Vessels Adrenergic alpha-2 Receptor Agonists Brimonidine Tartrate Neuroprotective Agents Somatostatin |
description |
PURPOSE. Structural retinal microvascular changes have been identified as risk markers of diabetic retinopathy (DR). In order to estimate the retinal response of neuroprotective eye drops, we aimed to evaluate the effect of topical retinal neuroprotection on retinal microvascular changes in early DR. METHODS. Patients with type 2 diabetes with no or early DR were randomized 1:1:1 to topical treatment with placebo, brimonidine, or somatostatin in a 96-week prospective, phase II to III, European multicenter trial. Retinal vascular calibers were measured semiautomatically in digital fundus images by certified graders at baseline and follow-up and summarized as central retinal arteriolar and venular equivalent (CRAE and CRVE). RESULTS. Of 449 patients originally included, 297 completed the study with gradable retinal images. Median age and duration of diabetes was 64.5 and 9.9 years, and 65.7% were male. At baseline, Early Treatment Diabetic Retinopathy Study levels were 10 (no DR, 42.8%), 20 (minimal DR, 28.3%), and 35 (mild DR, 29.0%), and CRAE and CRVE did not differ between groups. As opposed to patients with no or minimal DR at baseline, patients with mild DR in the active groups developed a larger retinal arteriolar (brimonidine: þ6.2 lm, P ¼ 0.006; somatostatin: þ7.2 lm, P ¼ 0.006) and venular (brimonidine: þ13.9 lm, P ¼ 0.01; somatostatin: þ14.3 lm, P ¼ 0.0001) caliber in contrast to those in the placebo group. CONCLUSIONS. Topical treatment with brimonidine and somatostatin causes retinal arteriolar and venular dilation in patients with type 2 diabetes and preexisting early DR. Upcoming studies should elaborate on the potential of these findings in arresting early DR. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/107074 http://hdl.handle.net/10316/107074 https://doi.org/10.1167/iovs.18-26487 |
url |
http://hdl.handle.net/10316/107074 https://doi.org/10.1167/iovs.18-26487 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1552-5783 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Association for Research in Vision and Ophthalmology |
publisher.none.fl_str_mv |
Association for Research in Vision and Ophthalmology |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134121521315840 |