Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/154617 |
Resumo: | Funding Information: The Group of Polymer of INTEC acknowledges the financial support from CONICET (PIP 11220200101353CO), ANPCyT (PICT-2020-SERIE A 2020-03156), and the National University of the Litoral (C.A.I. + D 50620190100117LI). Publisher Copyright: © 2023 by the authors. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Propertiesbiocompatible ionic liquidsiongelswound healingChemistry(all)Polymers and PlasticsFunding Information: The Group of Polymer of INTEC acknowledges the financial support from CONICET (PIP 11220200101353CO), ANPCyT (PICT-2020-SERIE A 2020-03156), and the National University of the Litoral (C.A.I. + D 50620190100117LI). Publisher Copyright: © 2023 by the authors.There is an actual need for developing materials for wound healing applications with anti-inflammatory, antioxidant, or antibacterial properties in order to improve the healing performance. In this work, we report the preparation and characterization of soft and bioactive iongel materials for patches, based on polymeric poly(vinyl alcohol) (PVA) and four ionic liquids containing the cholinium cation and different phenolic acid anions, namely cholinium salicylate ([Ch][Sal]), cholinium gallate ([Ch][Ga]), cholinium vanillate ([Ch][Van]), and cholinium caffeate ([Ch][Caff]). Within the iongels, the phenolic motif in the ionic liquids plays a dual role, acting as a PVA crosslinker and a bioactive compound. The obtained iongels are flexible, elastic, ionic conducting, and thermoreversible materials. Moreover, the iongels demonstrated high biocompatibility, non-hemolytic activity, and non-agglutination in mice blood, which are key-sought material specifications in wound healing applications. All the iongels have shown antibacterial properties, being PVA-[Ch][Sal], the one with higher inhibition halo for Escherichia Coli. The iongels also revealed high values of antioxidant activity due to the presence of the polyphenol, with the PVA-[Ch][Van] iongel having the highest activity. Finally, the iongels show a decrease in NO production in LPS-stimulated macrophages, with the PVA-[Ch][Sal] iongel displaying the best anti-inflammatory activity (>63% at 200 µg/mL).LAQV@REQUIMTEDQ - Departamento de QuímicaRUNLuque, Gisela C.Moya, MelissaPicchio, Matias L.Bagnarello, VanessaValerio, IdaliaBolaños, JoséVethencourt, MaríaGamboa, Sue HellenTomé, Liliana C.Minari, Roque J.Mecerreyes, David2023-06-29T22:16:54Z2023-02-212023-02-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/154617eng2073-4360PURE: 64820256https://doi.org/10.3390/polym15051076info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:05Zoai:run.unl.pt:10362/154617Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:41.900288Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties |
| title |
Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties |
| spellingShingle |
Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties Luque, Gisela C. biocompatible ionic liquids iongels wound healing Chemistry(all) Polymers and Plastics |
| title_short |
Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties |
| title_full |
Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties |
| title_fullStr |
Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties |
| title_full_unstemmed |
Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties |
| title_sort |
Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties |
| author |
Luque, Gisela C. |
| author_facet |
Luque, Gisela C. Moya, Melissa Picchio, Matias L. Bagnarello, Vanessa Valerio, Idalia Bolaños, José Vethencourt, María Gamboa, Sue Hellen Tomé, Liliana C. Minari, Roque J. Mecerreyes, David |
| author_role |
author |
| author2 |
Moya, Melissa Picchio, Matias L. Bagnarello, Vanessa Valerio, Idalia Bolaños, José Vethencourt, María Gamboa, Sue Hellen Tomé, Liliana C. Minari, Roque J. Mecerreyes, David |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
LAQV@REQUIMTE DQ - Departamento de Química RUN |
| dc.contributor.author.fl_str_mv |
Luque, Gisela C. Moya, Melissa Picchio, Matias L. Bagnarello, Vanessa Valerio, Idalia Bolaños, José Vethencourt, María Gamboa, Sue Hellen Tomé, Liliana C. Minari, Roque J. Mecerreyes, David |
| dc.subject.por.fl_str_mv |
biocompatible ionic liquids iongels wound healing Chemistry(all) Polymers and Plastics |
| topic |
biocompatible ionic liquids iongels wound healing Chemistry(all) Polymers and Plastics |
| description |
Funding Information: The Group of Polymer of INTEC acknowledges the financial support from CONICET (PIP 11220200101353CO), ANPCyT (PICT-2020-SERIE A 2020-03156), and the National University of the Litoral (C.A.I. + D 50620190100117LI). Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-06-29T22:16:54Z 2023-02-21 2023-02-21T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/154617 |
| url |
http://hdl.handle.net/10362/154617 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2073-4360 PURE: 64820256 https://doi.org/10.3390/polym15051076 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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16 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138143690031104 |