Changes in wavefront error of the eye for different accommodation targets under the application of phenylephrine hydrochloride
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/85541 |
Resumo: | Pharmacological dilation of the eye to have a larger pupil diameter may allow a better understanding of the wavefront error changes with accommodation. This work aimed to investigate whether dilation of the pupil with Phenylephrine Hydrochloride (PHCl) application changes the accommodative response and the Zernike coefficient magnitude with accommodative demand when computed to a common pupil size. Sixteen right eyes of healthy young subjects were measured with the commercial Hartmann–Shack aberrometer IRX3 (Imagine Eyes, Orsay, France) 30 min after two drops of 1.0% PHCl were applied. The eye wavefronts for accommodative demands from 0 to 5 D were measured in natural conditions and after pupil dilatation. Statistically significant differences between both conditions were found for the Zernike coefficients C −1 3 , C 1 3 , C 0 4 and C 0 6 . Without the effect of PHCl, higher values were found for all higher-order Zernike coefficients (HOA). With increased accommodative response, an increase of C −1 3 and a decrease of C 1 3 was observed and the C 0 4 becomes more negative; the change from positive to negative is shown in the accommodative demand of 1.5 D. Conversely, C 0 6 increases with increasing accommodative demand. To conclude, the results demonstrated that the mydriatic effect of PHCl causes changes in the magnitude of HOA when accommodation is stimulated. The trends observed in the different Zernike coefficients were the same reported in previous studies. |
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Changes in wavefront error of the eye for different accommodation targets under the application of phenylephrine hydrochlorideAccommodationMydriaticsPhenylephrineWavefront aberrationsZernike coefficientsScience & TechnologyPharmacological dilation of the eye to have a larger pupil diameter may allow a better understanding of the wavefront error changes with accommodation. This work aimed to investigate whether dilation of the pupil with Phenylephrine Hydrochloride (PHCl) application changes the accommodative response and the Zernike coefficient magnitude with accommodative demand when computed to a common pupil size. Sixteen right eyes of healthy young subjects were measured with the commercial Hartmann–Shack aberrometer IRX3 (Imagine Eyes, Orsay, France) 30 min after two drops of 1.0% PHCl were applied. The eye wavefronts for accommodative demands from 0 to 5 D were measured in natural conditions and after pupil dilatation. Statistically significant differences between both conditions were found for the Zernike coefficients C −1 3 , C 1 3 , C 0 4 and C 0 6 . Without the effect of PHCl, higher values were found for all higher-order Zernike coefficients (HOA). With increased accommodative response, an increase of C −1 3 and a decrease of C 1 3 was observed and the C 0 4 becomes more negative; the change from positive to negative is shown in the accommodative demand of 1.5 D. Conversely, C 0 6 increases with increasing accommodative demand. To conclude, the results demonstrated that the mydriatic effect of PHCl causes changes in the magnitude of HOA when accommodation is stimulated. The trends observed in the different Zernike coefficients were the same reported in previous studies.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant, agreement No. 956720.Multidisciplinary Digital Publishing InstituteUniversidade do MinhoGarcía, María MechóMartínez, Iñaki BlancoFernandes, PauloMacedo-de-Araújo, Rute J.Ribeiro, Miguel António FariaGonzález-Méijome, José Manuel2023-03-302023-03-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/85541engMechó-García, M.; Blanco-Martínez, I.; Fernandes, P.; Macedo-de-Araújo, R.J.; Faria-Ribeiro, M.; González-Méijome, J.M. Changes in Wavefront Error of the Eye for Different Accommodation Targets under the Application of Phenylephrine Hydrochloride. Photonics 2023, 10, 381. https://doi.org/10.3390/photonics100403812304-673210.3390/photonics10040381https://www.mdpi.com/2304-6732/10/4/381info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-14T01:19:03Zoai:repositorium.sdum.uminho.pt:1822/85541Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:26:28.899913Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Changes in wavefront error of the eye for different accommodation targets under the application of phenylephrine hydrochloride |
title |
Changes in wavefront error of the eye for different accommodation targets under the application of phenylephrine hydrochloride |
spellingShingle |
Changes in wavefront error of the eye for different accommodation targets under the application of phenylephrine hydrochloride García, María Mechó Accommodation Mydriatics Phenylephrine Wavefront aberrations Zernike coefficients Science & Technology |
title_short |
Changes in wavefront error of the eye for different accommodation targets under the application of phenylephrine hydrochloride |
title_full |
Changes in wavefront error of the eye for different accommodation targets under the application of phenylephrine hydrochloride |
title_fullStr |
Changes in wavefront error of the eye for different accommodation targets under the application of phenylephrine hydrochloride |
title_full_unstemmed |
Changes in wavefront error of the eye for different accommodation targets under the application of phenylephrine hydrochloride |
title_sort |
Changes in wavefront error of the eye for different accommodation targets under the application of phenylephrine hydrochloride |
author |
García, María Mechó |
author_facet |
García, María Mechó Martínez, Iñaki Blanco Fernandes, Paulo Macedo-de-Araújo, Rute J. Ribeiro, Miguel António Faria González-Méijome, José Manuel |
author_role |
author |
author2 |
Martínez, Iñaki Blanco Fernandes, Paulo Macedo-de-Araújo, Rute J. Ribeiro, Miguel António Faria González-Méijome, José Manuel |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
García, María Mechó Martínez, Iñaki Blanco Fernandes, Paulo Macedo-de-Araújo, Rute J. Ribeiro, Miguel António Faria González-Méijome, José Manuel |
dc.subject.por.fl_str_mv |
Accommodation Mydriatics Phenylephrine Wavefront aberrations Zernike coefficients Science & Technology |
topic |
Accommodation Mydriatics Phenylephrine Wavefront aberrations Zernike coefficients Science & Technology |
description |
Pharmacological dilation of the eye to have a larger pupil diameter may allow a better understanding of the wavefront error changes with accommodation. This work aimed to investigate whether dilation of the pupil with Phenylephrine Hydrochloride (PHCl) application changes the accommodative response and the Zernike coefficient magnitude with accommodative demand when computed to a common pupil size. Sixteen right eyes of healthy young subjects were measured with the commercial Hartmann–Shack aberrometer IRX3 (Imagine Eyes, Orsay, France) 30 min after two drops of 1.0% PHCl were applied. The eye wavefronts for accommodative demands from 0 to 5 D were measured in natural conditions and after pupil dilatation. Statistically significant differences between both conditions were found for the Zernike coefficients C −1 3 , C 1 3 , C 0 4 and C 0 6 . Without the effect of PHCl, higher values were found for all higher-order Zernike coefficients (HOA). With increased accommodative response, an increase of C −1 3 and a decrease of C 1 3 was observed and the C 0 4 becomes more negative; the change from positive to negative is shown in the accommodative demand of 1.5 D. Conversely, C 0 6 increases with increasing accommodative demand. To conclude, the results demonstrated that the mydriatic effect of PHCl causes changes in the magnitude of HOA when accommodation is stimulated. The trends observed in the different Zernike coefficients were the same reported in previous studies. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-30 2023-03-30T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/85541 |
url |
https://hdl.handle.net/1822/85541 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mechó-García, M.; Blanco-Martínez, I.; Fernandes, P.; Macedo-de-Araújo, R.J.; Faria-Ribeiro, M.; González-Méijome, J.M. Changes in Wavefront Error of the Eye for Different Accommodation Targets under the Application of Phenylephrine Hydrochloride. Photonics 2023, 10, 381. https://doi.org/10.3390/photonics10040381 2304-6732 10.3390/photonics10040381 https://www.mdpi.com/2304-6732/10/4/381 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132753426382848 |