Therapeutic avenues for γδ T cells in cancer

Detalhes bibliográficos
Autor(a) principal: Costa, Gonçalo Palrão
Data de Publicação: 2023
Outros Autores: Mensurado, Sofia, Silva-Santos, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/61037
Resumo: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.
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spelling Therapeutic avenues for γδ T cells in cancerImmunotherapy, ActiveImmunotherapy, AdoptiveT-Lymphocytes© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.γδ T cells are regarded as promising effector lymphocytes for next-generation cancer immunotherapies. In spite of being relatively rare in human peripheral blood, γδ T cells are more abundant in epithelial tissues where many tumors develop, and have been shown to actively participate in anticancer immunity as cytotoxic cells or as "type 1" immune orchestrators. A major asset of γδ T cells for tackling advanced cancers is their independence from antigen presentation via the major histocompatibility complex, which clearly sets them apart from conventional αβ T cells. Here we discuss the main therapeutic strategies based on human γδ T cells. These include antibody-based bispecific engagers and adoptive cell therapies, either focused on the Vδ1+ or Vδ2+ γδ T-cell subsets, which can be expanded selectively and differentiated or engineered to maximize their antitumor functions. We review the preclinical data that supports each of the therapeutic strategies under development; and summarize the clinical trials being pursued towards establishing γδ T cell-based treatments for solid and hematological malignancies.This study was funded by Fundação para a Ciência e Tecnologia of the Portuguese Ministério da Ciência, Tecnologia e Ensino Superior (PTDC/MED-ONC/6829/2020 to BS-S and 2021.01953.CEECIND to SM).BMJ Publishing GroupRepositório da Universidade de LisboaCosta, Gonçalo PalrãoMensurado, SofiaSilva-Santos, Bruno2023-11-30T14:20:50Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/61037engJ Immunother Cancer. 2023 Nov 24;11(11):e00795510.1136/jitc-2023-0079552051-1426info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-04T01:20:15Zoai:repositorio.ul.pt:10451/61037Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:40:54.411177Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Therapeutic avenues for γδ T cells in cancer
title Therapeutic avenues for γδ T cells in cancer
spellingShingle Therapeutic avenues for γδ T cells in cancer
Costa, Gonçalo Palrão
Immunotherapy, Active
Immunotherapy, Adoptive
T-Lymphocytes
title_short Therapeutic avenues for γδ T cells in cancer
title_full Therapeutic avenues for γδ T cells in cancer
title_fullStr Therapeutic avenues for γδ T cells in cancer
title_full_unstemmed Therapeutic avenues for γδ T cells in cancer
title_sort Therapeutic avenues for γδ T cells in cancer
author Costa, Gonçalo Palrão
author_facet Costa, Gonçalo Palrão
Mensurado, Sofia
Silva-Santos, Bruno
author_role author
author2 Mensurado, Sofia
Silva-Santos, Bruno
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Costa, Gonçalo Palrão
Mensurado, Sofia
Silva-Santos, Bruno
dc.subject.por.fl_str_mv Immunotherapy, Active
Immunotherapy, Adoptive
T-Lymphocytes
topic Immunotherapy, Active
Immunotherapy, Adoptive
T-Lymphocytes
description © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-30T14:20:50Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/61037
url http://hdl.handle.net/10451/61037
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Immunother Cancer. 2023 Nov 24;11(11):e007955
10.1136/jitc-2023-007955
2051-1426
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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