The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells

Detalhes bibliográficos
Autor(a) principal: Loureiro, Ana Isabel Sá
Data de Publicação: 2018
Outros Autores: Jennifer Noro, Abreu, Ana S., Nogueira, E., Soares da Costa, Diana, Silva, Carla, Cavaco-Paulo, Artur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/51753
Resumo: Novel nanoparticles based on Poloxamer 407 and vegetable oil were produced by high pressure homogenization. Functionalization of those nanoparticles was made by incorporation of folic acid (FA)-Poloxamer 407 conjugate. These nanoparticles showed suitable characteristics for intravenous therapeutic applications similarly to PEGylated albumin-based nanoparticles, previously described by our research group. Here, we found that the absence of albumin at the interface of Poloxamer 407-based nanoparticles improves the overall process of in vitro cellular uptake and nanoparticles disruption inside cancer cells (folate receptor, FR, positive cells). The results present here suggests that interfacial composition of those nanoparticles is of paramount importance for drug trafficking inside cancer cells.
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spelling The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cellsfolic acid-Poloxamer 407 conjugatefolic acid-Poloxamer 407 nanoparticlesnanoparticle disruptionspecific drug releasecancer therapyScience & TechnologyNovel nanoparticles based on Poloxamer 407 and vegetable oil were produced by high pressure homogenization. Functionalization of those nanoparticles was made by incorporation of folic acid (FA)-Poloxamer 407 conjugate. These nanoparticles showed suitable characteristics for intravenous therapeutic applications similarly to PEGylated albumin-based nanoparticles, previously described by our research group. Here, we found that the absence of albumin at the interface of Poloxamer 407-based nanoparticles improves the overall process of in vitro cellular uptake and nanoparticles disruption inside cancer cells (folate receptor, FR, positive cells). The results present here suggests that interfacial composition of those nanoparticles is of paramount importance for drug trafficking inside cancer cells.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by European Regional Development Fund under the scope of Norte2020Programa Operacional Regional do Norte. This work has received funding from the European Union Horizon 2020 research and innovation program under Grant Agreement NMP-06-2015-683356 FOLSMART. Diana Soares da Costa thanks Portuguese Foundation for Science and Technology (FCT) for funding her scholarship SFRH/BPD/85790/2012.info:eu-repo/semantics/publishedVersionAmerican Chemical SocietyUniversidade do MinhoLoureiro, Ana Isabel SáJennifer NoroAbreu, Ana S.Nogueira, E.Soares da Costa, DianaSilva, CarlaCavaco-Paulo, Artur2018-022018-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/51753engLoureiro, Ana; Jennifer Noro; Abreu, Ana S.; Nogueira, E.; Soares da Costa, Diana; Silva, Carla; Cavaco-Paulo, Artur, The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells.154383841543-838210.1021/acs.molpharmaceut.7b0089329291347http://pubs.acs.org/journal/mpohbpinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:22:20Zoai:repositorium.sdum.uminho.pt:1822/51753Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:15:47.922010Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells
title The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells
spellingShingle The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells
Loureiro, Ana Isabel Sá
folic acid-Poloxamer 407 conjugate
folic acid-Poloxamer 407 nanoparticles
nanoparticle disruption
specific drug release
cancer therapy
Science & Technology
title_short The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells
title_full The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells
title_fullStr The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells
title_full_unstemmed The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells
title_sort The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells
author Loureiro, Ana Isabel Sá
author_facet Loureiro, Ana Isabel Sá
Jennifer Noro
Abreu, Ana S.
Nogueira, E.
Soares da Costa, Diana
Silva, Carla
Cavaco-Paulo, Artur
author_role author
author2 Jennifer Noro
Abreu, Ana S.
Nogueira, E.
Soares da Costa, Diana
Silva, Carla
Cavaco-Paulo, Artur
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Loureiro, Ana Isabel Sá
Jennifer Noro
Abreu, Ana S.
Nogueira, E.
Soares da Costa, Diana
Silva, Carla
Cavaco-Paulo, Artur
dc.subject.por.fl_str_mv folic acid-Poloxamer 407 conjugate
folic acid-Poloxamer 407 nanoparticles
nanoparticle disruption
specific drug release
cancer therapy
Science & Technology
topic folic acid-Poloxamer 407 conjugate
folic acid-Poloxamer 407 nanoparticles
nanoparticle disruption
specific drug release
cancer therapy
Science & Technology
description Novel nanoparticles based on Poloxamer 407 and vegetable oil were produced by high pressure homogenization. Functionalization of those nanoparticles was made by incorporation of folic acid (FA)-Poloxamer 407 conjugate. These nanoparticles showed suitable characteristics for intravenous therapeutic applications similarly to PEGylated albumin-based nanoparticles, previously described by our research group. Here, we found that the absence of albumin at the interface of Poloxamer 407-based nanoparticles improves the overall process of in vitro cellular uptake and nanoparticles disruption inside cancer cells (folate receptor, FR, positive cells). The results present here suggests that interfacial composition of those nanoparticles is of paramount importance for drug trafficking inside cancer cells.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
2018-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/51753
url http://hdl.handle.net/1822/51753
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Loureiro, Ana; Jennifer Noro; Abreu, Ana S.; Nogueira, E.; Soares da Costa, Diana; Silva, Carla; Cavaco-Paulo, Artur, The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells.
15438384
1543-8382
10.1021/acs.molpharmaceut.7b00893
29291347
http://pubs.acs.org/journal/mpohbp
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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