Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives

Detalhes bibliográficos
Autor(a) principal: Gil-Longo, José
Data de Publicação: 1993
Outros Autores: Laguna, Maria de los Reyes, Verde, Ignacio, Castro, Elena, Orallo, Francisco, Fontenla, Jose A., Calleja, José Maria, Ravina, Enrique, Terán, Carmen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/558
Resumo: 3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.
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spelling Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.uBibliorumGil-Longo, JoséLaguna, Maria de los ReyesVerde, IgnacioCastro, ElenaOrallo, FranciscoFontenla, Jose A.Calleja, José MariaRavina, EnriqueTerán, Carmen2010-04-28T10:06:49Z19931993-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/558enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:35:47Zoai:ubibliorum.ubi.pt:10400.6/558Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:42:36.238323Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives
title Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives
spellingShingle Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives
Gil-Longo, José
title_short Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives
title_full Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives
title_fullStr Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives
title_full_unstemmed Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives
title_sort Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-C]pyridazine and its hydrazone derivatives
author Gil-Longo, José
author_facet Gil-Longo, José
Laguna, Maria de los Reyes
Verde, Ignacio
Castro, Elena
Orallo, Francisco
Fontenla, Jose A.
Calleja, José Maria
Ravina, Enrique
Terán, Carmen
author_role author
author2 Laguna, Maria de los Reyes
Verde, Ignacio
Castro, Elena
Orallo, Francisco
Fontenla, Jose A.
Calleja, José Maria
Ravina, Enrique
Terán, Carmen
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Gil-Longo, José
Laguna, Maria de los Reyes
Verde, Ignacio
Castro, Elena
Orallo, Francisco
Fontenla, Jose A.
Calleja, José Maria
Ravina, Enrique
Terán, Carmen
description 3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.
publishDate 1993
dc.date.none.fl_str_mv 1993
1993-01-01T00:00:00Z
2010-04-28T10:06:49Z
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