Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials

Detalhes bibliográficos
Autor(a) principal: Carvalho, Carla C. C. R. de
Data de Publicação: 2020
Outros Autores: Teixeira, Raquel, Fernandes, Pedro Carlos de Barros
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10437/12143
Resumo: Mycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, M. vaccae cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole.
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spelling Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobialsBIOTECNOLOGIAANTIBIÓTICOSBACTÉRIASANTIMICROBIANOSPERMEABILIDADEBIOTECHNOLOGYANTIBIOTICSBACTERIAANTIMICROBIALPERMEABILITYMycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, M. vaccae cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole.MDPI2021-09-06T10:23:17Z2020-01-01T00:00:00Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10437/12143eng10.3390/antibiotics9090544Carvalho, Carla C. C. R. deTeixeira, RaquelFernandes, Pedro Carlos de Barrosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-09T14:04:21Zoai:recil.ensinolusofona.pt:10437/12143Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:12:21.949296Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials
title Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials
spellingShingle Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials
Carvalho, Carla C. C. R. de
BIOTECNOLOGIA
ANTIBIÓTICOS
BACTÉRIAS
ANTIMICROBIANOS
PERMEABILIDADE
BIOTECHNOLOGY
ANTIBIOTICS
BACTERIA
ANTIMICROBIAL
PERMEABILITY
title_short Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials
title_full Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials
title_fullStr Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials
title_full_unstemmed Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials
title_sort Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials
author Carvalho, Carla C. C. R. de
author_facet Carvalho, Carla C. C. R. de
Teixeira, Raquel
Fernandes, Pedro Carlos de Barros
author_role author
author2 Teixeira, Raquel
Fernandes, Pedro Carlos de Barros
author2_role author
author
dc.contributor.author.fl_str_mv Carvalho, Carla C. C. R. de
Teixeira, Raquel
Fernandes, Pedro Carlos de Barros
dc.subject.por.fl_str_mv BIOTECNOLOGIA
ANTIBIÓTICOS
BACTÉRIAS
ANTIMICROBIANOS
PERMEABILIDADE
BIOTECHNOLOGY
ANTIBIOTICS
BACTERIA
ANTIMICROBIAL
PERMEABILITY
topic BIOTECNOLOGIA
ANTIBIÓTICOS
BACTÉRIAS
ANTIMICROBIANOS
PERMEABILIDADE
BIOTECHNOLOGY
ANTIBIOTICS
BACTERIA
ANTIMICROBIAL
PERMEABILITY
description Mycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, M. vaccae cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01T00:00:00Z
2020
2021-09-06T10:23:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10437/12143
url http://hdl.handle.net/10437/12143
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.3390/antibiotics9090544
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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