Production of Poly(vinyl alcohol) (PVA) fibers with encapsulated natural deep eutectic solvent (NADES) using electrospinning

• Autor(a) principal: Mano, Francisca
• Data de Publicação: 2015
• Outros Autores: Aroso, Ivo Manuel Ascensão, Barreiros, Susana, Borges, João Paulo, Reis, R. L., Duarte, Ana Rita C., Paiva, Alexandre
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://hdl.handle.net/1822/38366
• topic: Electrospinning; Natural Deep-eutectic solvents; Poly(vinyl alcohol); Ciências Médicas::Biotecnologia Médica

Functionalized electrospun fibers are of great interest for biomedical applications such as in the design of drug delivery systems. Nevertheless, in some cases the molecules of interest have poor solubility in water or have high melting temperatures. These drawbacks can be overcome using deep eutectic solvents. In this work, poly(vinyl alcohol) (PVA), a common biodegradable biopolymer, was used to produce new functionalized fibers with the eutectic mixture choline chloride:citric acid in a molar ratio of (1:1) ChCl:CA (1:1), which was used as a model system. Fibers were produced from an aqueous solution with 7.8% (w/v) and 9.8% (w/v) of 95% hydrolyzed PVA and a 2% (v/v) of ChCl:CA (1:1). Smooth, uniform fibers with an average diameter of 0.4 μm were obtained with a content of 19.8 wt % of ChCl:CA (1:1) encapsulated