Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells
Autor(a) principal: | |
---|---|
Data de Publicação: | 2007 |
Outros Autores: | , , , |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10884/475 |
Resumo: | The aim of this study was to search for new multidrug resistance reversal agents from Euphorbia species. In this way, three new jatophane diterpenes (1 – 3) isolated from E.tuckeyana (Fig. 1) and three new lathyrane esters (4 - 6) obtained through acylation reations of latilagascene B (Fig. 4), have been screened for their potential P-gp modulating properties on mouse resistance cancer cell lines. Furthermore, in the combination chemotherapy model, the interaction between the cytostatic epirubicine and the six diterpenes were also evaluated. |
id |
RCAP_6d16ee4bd0b5e30b973103120bbb6cba |
---|---|
oai_identifier_str |
oai:repositorio-cientifico.uatlantica.pt:10884/475 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cellsDiterpenesEpirubicineCancerThe aim of this study was to search for new multidrug resistance reversal agents from Euphorbia species. In this way, three new jatophane diterpenes (1 – 3) isolated from E.tuckeyana (Fig. 1) and three new lathyrane esters (4 - 6) obtained through acylation reations of latilagascene B (Fig. 4), have been screened for their potential P-gp modulating properties on mouse resistance cancer cell lines. Furthermore, in the combination chemotherapy model, the interaction between the cytostatic epirubicine and the six diterpenes were also evaluated.2012-03-06T12:00:19Z2007-01-01T00:00:00Z2007conference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10884/475engDuarte, NJárdánházy, ARamalhete, CátiaMolnar, JFerreira, MJUinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-31T15:59:25Zoai:repositorio-cientifico.uatlantica.pt:10884/475Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-31T15:59:25Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells |
title |
Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells |
spellingShingle |
Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells Duarte, N Diterpenes Epirubicine Cancer |
title_short |
Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells |
title_full |
Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells |
title_fullStr |
Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells |
title_full_unstemmed |
Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells |
title_sort |
Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells |
author |
Duarte, N |
author_facet |
Duarte, N Járdánházy, A Ramalhete, Cátia Molnar, J Ferreira, MJU |
author_role |
author |
author2 |
Járdánházy, A Ramalhete, Cátia Molnar, J Ferreira, MJU |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Duarte, N Járdánházy, A Ramalhete, Cátia Molnar, J Ferreira, MJU |
dc.subject.por.fl_str_mv |
Diterpenes Epirubicine Cancer |
topic |
Diterpenes Epirubicine Cancer |
description |
The aim of this study was to search for new multidrug resistance reversal agents from Euphorbia species. In this way, three new jatophane diterpenes (1 – 3) isolated from E.tuckeyana (Fig. 1) and three new lathyrane esters (4 - 6) obtained through acylation reations of latilagascene B (Fig. 4), have been screened for their potential P-gp modulating properties on mouse resistance cancer cell lines. Furthermore, in the combination chemotherapy model, the interaction between the cytostatic epirubicine and the six diterpenes were also evaluated. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01T00:00:00Z 2007 2012-03-06T12:00:19Z |
dc.type.driver.fl_str_mv |
conference object |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10884/475 |
url |
http://hdl.handle.net/10884/475 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817548668111159296 |