Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells

Detalhes bibliográficos
Autor(a) principal: Duarte, N
Data de Publicação: 2007
Outros Autores: Járdánházy, A, Ramalhete, Cátia, Molnar, J, Ferreira, MJU
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10884/475
Resumo: The aim of this study was to search for new multidrug resistance reversal agents from Euphorbia species. In this way, three new jatophane diterpenes (1 – 3) isolated from E.tuckeyana (Fig. 1) and three new lathyrane esters (4 - 6) obtained through acylation reations of latilagascene B (Fig. 4), have been screened for their potential P-gp modulating properties on mouse resistance cancer cell lines. Furthermore, in the combination chemotherapy model, the interaction between the cytostatic epirubicine and the six diterpenes were also evaluated.
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spelling Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cellsDiterpenesEpirubicineCancerThe aim of this study was to search for new multidrug resistance reversal agents from Euphorbia species. In this way, three new jatophane diterpenes (1 – 3) isolated from E.tuckeyana (Fig. 1) and three new lathyrane esters (4 - 6) obtained through acylation reations of latilagascene B (Fig. 4), have been screened for their potential P-gp modulating properties on mouse resistance cancer cell lines. Furthermore, in the combination chemotherapy model, the interaction between the cytostatic epirubicine and the six diterpenes were also evaluated.2012-03-06T12:00:19Z2007-01-01T00:00:00Z2007conference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10884/475engDuarte, NJárdánházy, ARamalhete, CátiaMolnar, JFerreira, MJUinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-31T15:59:25Zoai:repositorio-cientifico.uatlantica.pt:10884/475Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-31T15:59:25Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells
title Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells
spellingShingle Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells
Duarte, N
Diterpenes
Epirubicine
Cancer
title_short Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells
title_full Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells
title_fullStr Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells
title_full_unstemmed Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells
title_sort Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells
author Duarte, N
author_facet Duarte, N
Járdánházy, A
Ramalhete, Cátia
Molnar, J
Ferreira, MJU
author_role author
author2 Járdánházy, A
Ramalhete, Cátia
Molnar, J
Ferreira, MJU
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Duarte, N
Járdánházy, A
Ramalhete, Cátia
Molnar, J
Ferreira, MJU
dc.subject.por.fl_str_mv Diterpenes
Epirubicine
Cancer
topic Diterpenes
Epirubicine
Cancer
description The aim of this study was to search for new multidrug resistance reversal agents from Euphorbia species. In this way, three new jatophane diterpenes (1 – 3) isolated from E.tuckeyana (Fig. 1) and three new lathyrane esters (4 - 6) obtained through acylation reations of latilagascene B (Fig. 4), have been screened for their potential P-gp modulating properties on mouse resistance cancer cell lines. Furthermore, in the combination chemotherapy model, the interaction between the cytostatic epirubicine and the six diterpenes were also evaluated.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01T00:00:00Z
2007
2012-03-06T12:00:19Z
dc.type.driver.fl_str_mv conference object
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10884/475
url http://hdl.handle.net/10884/475
dc.language.iso.fl_str_mv eng
language eng
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repository.mail.fl_str_mv mluisa.alvim@gmail.com
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