Receptors and routes of dengue virus entry into the host cells

Detalhes bibliográficos
Autor(a) principal: Cruz-Oliveira, Christine
Data de Publicação: 2015
Outros Autores: Freire, João Miguel, Conceição, Thaís M., Higa, Luiza M., Castanho, Miguel A. R. B., Poian, Andrea T. da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/23252
Resumo: © FEMS 2014. All rights reserved
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spelling Receptors and routes of dengue virus entry into the host cellsFlavivirusViral structural proteinsVirus recognitionInternalization routesMembrane fusionGenome translocation© FEMS 2014. All rights reservedDengue is the most prevalent arthropod-borne viral disease, caused by dengue virus, a member of the Flaviviridae family. Its worldwide incidence is now a major health problem, with 2.5 billion people living in risk areas. In this review, we integrate the structural rearrangements of each viral protein and their functions in all the steps of virus entry into the host cells. We describe in detail the putative receptors and attachment factors in mammalian and mosquito cells, and the recognition of viral immunocomplexes via Fcγ receptor in immune cells. We also discuss that virus internalization might occur through distinct entry pathways, including clathrin-mediated or non-classical clathrin-independent endocytosis, depending on the host cell and virus serotype or strain. The implications of viral maturation in virus entry are also explored. Finally, we discuss the mechanisms of viral genome access to the cytoplasm. This includes the role of low pH-induced conformational changes in the envelope protein that mediate membrane fusion, and original insights raised by our recent work that supports the hypothesis that capsid protein would also be an active player in this process, acting on viral genome translocation into the cytoplasm.This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil, Projects 471239/2012-7 and 306669/2013-7), Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ, Brazil, Projects E-26/102.919/2011 and E-26/111.668/2013), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil, Project 171/2012), Fundação para a Ciência e Tecnologia – Ministério da Educação e Ciência (FCT-MEC, Portugal, Project PTDC/QUI-BIQ/112929/2009).Oxford University PressRepositório da Universidade de LisboaCruz-Oliveira, ChristineFreire, João MiguelConceição, Thaís M.Higa, Luiza M.Castanho, Miguel A. R. B.Poian, Andrea T. da2016-04-05T14:42:09Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/23252engFEMS Microbiology Reviews, 39, 2015, 155–1700168-6445doi: 10.1093/femsre/fuu004metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:11:13Zoai:repositorio.ul.pt:10451/23252Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:40:41.509846Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Receptors and routes of dengue virus entry into the host cells
title Receptors and routes of dengue virus entry into the host cells
spellingShingle Receptors and routes of dengue virus entry into the host cells
Cruz-Oliveira, Christine
Flavivirus
Viral structural proteins
Virus recognition
Internalization routes
Membrane fusion
Genome translocation
title_short Receptors and routes of dengue virus entry into the host cells
title_full Receptors and routes of dengue virus entry into the host cells
title_fullStr Receptors and routes of dengue virus entry into the host cells
title_full_unstemmed Receptors and routes of dengue virus entry into the host cells
title_sort Receptors and routes of dengue virus entry into the host cells
author Cruz-Oliveira, Christine
author_facet Cruz-Oliveira, Christine
Freire, João Miguel
Conceição, Thaís M.
Higa, Luiza M.
Castanho, Miguel A. R. B.
Poian, Andrea T. da
author_role author
author2 Freire, João Miguel
Conceição, Thaís M.
Higa, Luiza M.
Castanho, Miguel A. R. B.
Poian, Andrea T. da
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cruz-Oliveira, Christine
Freire, João Miguel
Conceição, Thaís M.
Higa, Luiza M.
Castanho, Miguel A. R. B.
Poian, Andrea T. da
dc.subject.por.fl_str_mv Flavivirus
Viral structural proteins
Virus recognition
Internalization routes
Membrane fusion
Genome translocation
topic Flavivirus
Viral structural proteins
Virus recognition
Internalization routes
Membrane fusion
Genome translocation
description © FEMS 2014. All rights reserved
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2016-04-05T14:42:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/23252
url http://hdl.handle.net/10451/23252
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv FEMS Microbiology Reviews, 39, 2015, 155–170
0168-6445
doi: 10.1093/femsre/fuu004
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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