Impact of Psychopharmaceuticals On Visual System of Non-Targeted Aquatic Organisms

• Autor(a) principal: Barros, Eduarda Daniela Silva
• Data de Publicação: 2021
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.22/17518
• topic: Antidepressants; Fish; Biological impact; Gene expression; Visual System; Antidepressivos; Peixe; Impacto Biológico; Expressão Génica

Antidepressants are among the most identified pharmaceuticals in aqueous system, and, as emerging organic pollutants, can exert negative effects of non-target aquatic organisms. As the concentrations in the environment are incessantly increasing the biological impacts of theses compounds in fish have beeun under discussion. The exposure to these pharmaceuticals porducts has been prodicung alterations in behaviour, reproduction, and development. Also, studies demonstrate that exposure to antidepressants result in a substantial rise in mortality, development retardation, morphological anomalies, and pathological changes in brain, heart, and ranial and caudal kidney. The development of the brain and visual system is particularly susceptible to the effects of prenatal exposure to neuroactive drugs. Assessing the visual motor responce in zebrafish, demonstrated that antidepressants most regularly modify the profile os spontaneous locomotion having significant variation in behavioral effects. In fish, global gene expression analysis can reveal effects of toxicants on unexpected biochemical pathways, elucidate mechanisms of toxicity and be utilized for assessment of gene expression profiles to define differences/similarities in responses of organisms to toxicants. The aim of this syudy is to summarize current knowledge about the impacts of neuroactive compounds on non-target animals living in surface waters, especially at the level of the brain and visual system.