Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/152458 |
Resumo: | The awareness of epigenetic alterations leading to neoplasia attracted the attention of researchers toward its potential use in the management of cancer, from diagnosis to prognosis and prediction of response to therapies. Our group has focused its attention on the epigenomics of thyroid neoplasms. Although most of the epigenetic studies have been applied on histological samples, the fact is that cytology, through fine-needle aspiration, is a primary diagnostic method for many pathologies, of which thyroid nodules are one of the most paradigmatic examples. This has led to an increasing literature report of epigenetic studies using these biological samples over the past decade. In this review, our group aimed to document recent research of epigenetic alterations and its associated assessment techniques, based on cytology material. Our review covers the main epigenetic categories—DNA methylation, histone modification, and RNA-silencing—whose evidence in thyroid cytology samples may represent solid soil for future prospectively designed studies aiming at validating patterns of epigenetic alterations and their potential use in the clinical management of thyroid neoplasms. |
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Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid SpecimensEpigenetic markers of thyroidEpigeneticsEpigenomicsThyroid cancerThyroid fine needle aspirationThyroid tumorThe awareness of epigenetic alterations leading to neoplasia attracted the attention of researchers toward its potential use in the management of cancer, from diagnosis to prognosis and prediction of response to therapies. Our group has focused its attention on the epigenomics of thyroid neoplasms. Although most of the epigenetic studies have been applied on histological samples, the fact is that cytology, through fine-needle aspiration, is a primary diagnostic method for many pathologies, of which thyroid nodules are one of the most paradigmatic examples. This has led to an increasing literature report of epigenetic studies using these biological samples over the past decade. In this review, our group aimed to document recent research of epigenetic alterations and its associated assessment techniques, based on cytology material. Our review covers the main epigenetic categories—DNA methylation, histone modification, and RNA-silencing—whose evidence in thyroid cytology samples may represent solid soil for future prospectively designed studies aiming at validating patterns of epigenetic alterations and their potential use in the clinical management of thyroid neoplasms.Frontiers Media20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/152458eng2296-858X10.3389/fmed.2021.640460Canberk, SLima, ARPinto, MMáximo, Vinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:36:04Zoai:repositorio-aberto.up.pt:10216/152458Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:04:52.872715Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens |
title |
Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens |
spellingShingle |
Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens Canberk, S Epigenetic markers of thyroid Epigenetics Epigenomics Thyroid cancer Thyroid fine needle aspiration Thyroid tumor |
title_short |
Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens |
title_full |
Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens |
title_fullStr |
Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens |
title_full_unstemmed |
Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens |
title_sort |
Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens |
author |
Canberk, S |
author_facet |
Canberk, S Lima, AR Pinto, M Máximo, V |
author_role |
author |
author2 |
Lima, AR Pinto, M Máximo, V |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Canberk, S Lima, AR Pinto, M Máximo, V |
dc.subject.por.fl_str_mv |
Epigenetic markers of thyroid Epigenetics Epigenomics Thyroid cancer Thyroid fine needle aspiration Thyroid tumor |
topic |
Epigenetic markers of thyroid Epigenetics Epigenomics Thyroid cancer Thyroid fine needle aspiration Thyroid tumor |
description |
The awareness of epigenetic alterations leading to neoplasia attracted the attention of researchers toward its potential use in the management of cancer, from diagnosis to prognosis and prediction of response to therapies. Our group has focused its attention on the epigenomics of thyroid neoplasms. Although most of the epigenetic studies have been applied on histological samples, the fact is that cytology, through fine-needle aspiration, is a primary diagnostic method for many pathologies, of which thyroid nodules are one of the most paradigmatic examples. This has led to an increasing literature report of epigenetic studies using these biological samples over the past decade. In this review, our group aimed to document recent research of epigenetic alterations and its associated assessment techniques, based on cytology material. Our review covers the main epigenetic categories—DNA methylation, histone modification, and RNA-silencing—whose evidence in thyroid cytology samples may represent solid soil for future prospectively designed studies aiming at validating patterns of epigenetic alterations and their potential use in the clinical management of thyroid neoplasms. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/152458 |
url |
https://hdl.handle.net/10216/152458 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2296-858X 10.3389/fmed.2021.640460 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135972758126592 |