The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population

Detalhes bibliográficos
Autor(a) principal: Bettencourt, Andreia
Data de Publicação: 2017
Outros Autores: Boleixa, Daniela, Guimarães, Ana Luísa, Leal, Bárbara, Carvalho, Cláudia, Brás, Sandra, Samões, Raquel, Santos, Ernestina, Costa, Paulo Pinho, Silva, Berta, da Silva, Ana Martins
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/5467
Resumo: The cause of Multiple Sclerosis (MS) remains poorly understood, but it is widely believed to be an autoimmune disease occurring in genetically susceptible individuals after exposure to as-yet undefined environmental factors. One of these environmental factors is vitamin D, a well-known immune modulator. The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3, has been shown to exert its immune modulatory properties through its nuclear receptor (VDR) namely by inhibiting the proliferation of Th cells. The purpose of this study was to evaluate the influence of FokI VDR polymorphism in MS development and progression.
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spelling The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese populationAdultDeoxyribonucleases, Type II Site-SpecificFemaleHumansMaleMultiple SclerosisPolymorphism, Single NucleotidePortugalReceptors, CalcitriolYoung AdultDoenças GenéticasThe cause of Multiple Sclerosis (MS) remains poorly understood, but it is widely believed to be an autoimmune disease occurring in genetically susceptible individuals after exposure to as-yet undefined environmental factors. One of these environmental factors is vitamin D, a well-known immune modulator. The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3, has been shown to exert its immune modulatory properties through its nuclear receptor (VDR) namely by inhibiting the proliferation of Th cells. The purpose of this study was to evaluate the influence of FokI VDR polymorphism in MS development and progression.Elsevier/International Society for NeuroimmunologyRepositório Científico do Instituto Nacional de SaúdeBettencourt, AndreiaBoleixa, DanielaGuimarães, Ana LuísaLeal, BárbaraCarvalho, CláudiaBrás, SandraSamões, RaquelSantos, ErnestinaCosta, Paulo PinhoSilva, Bertada Silva, Ana Martins2018-03-22T19:55:39Z2017-08-152017-08-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5467engJ Neuroimmunol. 2017 Aug 15;309:34-37. doi: 10.1016/j.jneuroim.2017.05.005. Epub 2017 May 11.0165-572810.1016/j.jneuroim.2017.05.005info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:52Zoai:repositorio.insa.pt:10400.18/5467Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:09.509583Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population
title The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population
spellingShingle The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population
Bettencourt, Andreia
Adult
Deoxyribonucleases, Type II Site-Specific
Female
Humans
Male
Multiple Sclerosis
Polymorphism, Single Nucleotide
Portugal
Receptors, Calcitriol
Young Adult
Doenças Genéticas
title_short The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population
title_full The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population
title_fullStr The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population
title_full_unstemmed The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population
title_sort The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population
author Bettencourt, Andreia
author_facet Bettencourt, Andreia
Boleixa, Daniela
Guimarães, Ana Luísa
Leal, Bárbara
Carvalho, Cláudia
Brás, Sandra
Samões, Raquel
Santos, Ernestina
Costa, Paulo Pinho
Silva, Berta
da Silva, Ana Martins
author_role author
author2 Boleixa, Daniela
Guimarães, Ana Luísa
Leal, Bárbara
Carvalho, Cláudia
Brás, Sandra
Samões, Raquel
Santos, Ernestina
Costa, Paulo Pinho
Silva, Berta
da Silva, Ana Martins
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Bettencourt, Andreia
Boleixa, Daniela
Guimarães, Ana Luísa
Leal, Bárbara
Carvalho, Cláudia
Brás, Sandra
Samões, Raquel
Santos, Ernestina
Costa, Paulo Pinho
Silva, Berta
da Silva, Ana Martins
dc.subject.por.fl_str_mv Adult
Deoxyribonucleases, Type II Site-Specific
Female
Humans
Male
Multiple Sclerosis
Polymorphism, Single Nucleotide
Portugal
Receptors, Calcitriol
Young Adult
Doenças Genéticas
topic Adult
Deoxyribonucleases, Type II Site-Specific
Female
Humans
Male
Multiple Sclerosis
Polymorphism, Single Nucleotide
Portugal
Receptors, Calcitriol
Young Adult
Doenças Genéticas
description The cause of Multiple Sclerosis (MS) remains poorly understood, but it is widely believed to be an autoimmune disease occurring in genetically susceptible individuals after exposure to as-yet undefined environmental factors. One of these environmental factors is vitamin D, a well-known immune modulator. The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3, has been shown to exert its immune modulatory properties through its nuclear receptor (VDR) namely by inhibiting the proliferation of Th cells. The purpose of this study was to evaluate the influence of FokI VDR polymorphism in MS development and progression.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-15
2017-08-15T00:00:00Z
2018-03-22T19:55:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/5467
url http://hdl.handle.net/10400.18/5467
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Neuroimmunol. 2017 Aug 15;309:34-37. doi: 10.1016/j.jneuroim.2017.05.005. Epub 2017 May 11.
0165-5728
10.1016/j.jneuroim.2017.05.005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier/International Society for Neuroimmunology
publisher.none.fl_str_mv Elsevier/International Society for Neuroimmunology
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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