Peritoneal microbiome in end-stage renal disease patients and the impact of peritoneal dialysis therapy

Detalhes bibliográficos
Autor(a) principal: Simões-Silva, Liliana
Data de Publicação: 2020
Outros Autores: Araujo, Ricardo, Pestana, Manuel, Soares-Silva, Isabel, Sampaio-Maia, Benedita
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/64446
Resumo: The following are available online at http://www.mdpi.com/2076-2607/8/2/173/s1, Figure S1 (Rarefaction curves), Figure S2 (Relative proportion taxa for class, order, genus, and species), Figure S3 (Abundances of the genera and families between the ESRD-PD and ESRD-nonPD), Figure S4 (Alpha diversity of the peritoneum microbiome community at phylum, class, order, family, genus, species and OUT taxonomic levels calculated with Observed, Chao1, Shannon, Simpson, and Inverse Simpson indexes), Figure S5 (Beta-diversity of the peritoneum microbiome community at OTU level with Bray-Curtis, Jaccard, unweighted Unifrac, and Weighted Unifrac) and Figure S6 (Non-metric multidimensional scaling of blood and peritoneum microbiomes of non-PD and PD patients).
id RCAP_6e62c692ebcbe25dc7904a6515ec119c
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/64446
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Peritoneal microbiome in end-stage renal disease patients and the impact of peritoneal dialysis therapymicrobiomeperitoneumchronic kidney diseaseperitoneal dialysisend-stage kidney diseaseScience & TechnologyThe following are available online at http://www.mdpi.com/2076-2607/8/2/173/s1, Figure S1 (Rarefaction curves), Figure S2 (Relative proportion taxa for class, order, genus, and species), Figure S3 (Abundances of the genera and families between the ESRD-PD and ESRD-nonPD), Figure S4 (Alpha diversity of the peritoneum microbiome community at phylum, class, order, family, genus, species and OUT taxonomic levels calculated with Observed, Chao1, Shannon, Simpson, and Inverse Simpson indexes), Figure S5 (Beta-diversity of the peritoneum microbiome community at OTU level with Bray-Curtis, Jaccard, unweighted Unifrac, and Weighted Unifrac) and Figure S6 (Non-metric multidimensional scaling of blood and peritoneum microbiomes of non-PD and PD patients).Factors influencing the occurrence of peritoneal dialysis (PD)-related infections are still far from fully understood. Recent studies described the existence of specific microbiomes in body sites previously considered microbiome-free, unravelling new microbial pathways in the human body. In the present study, we analyzed the peritoneum of end-stage kidney disease (ESKD) patients to determine if they harbored a specific microbiome and if it is altered in patients on PD therapy. We conducted a cross-sectional study where the peritoneal microbiomes from ESKD patients with intact peritoneal cavities (ESKD non-PD, <i>n</i> = 11) and ESKD patients undergoing PD therapy (ESKD PD, <i>n</i> = 9) were analyzed with a 16S rRNA approach. Peritoneal tissue of ESKD patients contained characteristically low-abundance microbiomes dominated by Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes. Patients undergoing PD therapy presented lower species richness, with dominance by the Pseudomonadaceae and Prevotelaceae families. This study provides the first characterization of the peritoneal microbiome in ESKD patients, bringing new insight to the human microbiome. Additionally, PD therapy may induce changes in this unique microbiome. The clinical relevance of these observations should be further explored to uncover the role of the peritoneal microbiome as a key element in the onset or aggravation of infection in ESKD patients, especially those undergoing PD.This research was funded by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT/MCTES in the framework of the project MicroMOB “POCI-01-0145-FEDER-029777 / PTDC/MEC-MCI/29777/2017”; and by a Research Grant 2014 by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) to I.S.-S. L.S.-S was supported by SFRH/BD/84837/2012 and I.S.-S was supported by SFRH/BPD/101016/2014 from FCT/QREN–POPH/FSE.Multidisciplinary Digital Publishing InstituteUniversidade do MinhoSimões-Silva, LilianaAraujo, RicardoPestana, ManuelSoares-Silva, IsabelSampaio-Maia, Benedita2020-01-252020-01-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/64446engSimões-Silva, L.; Araujo, R.; Pestana, M.; Soares-Silva, I.; Sampaio-Maia, B. Peritoneal Microbiome in End-Stage Renal Disease Patients and the Impact of Peritoneal Dialysis Therapy. Microorganisms 2020, 8, 173.10.3390/microorganisms8020173https://www.mdpi.com/2076-2607/8/2/173info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:34:56Zoai:repositorium.sdum.uminho.pt:1822/64446Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:30:42.602017Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Peritoneal microbiome in end-stage renal disease patients and the impact of peritoneal dialysis therapy
title Peritoneal microbiome in end-stage renal disease patients and the impact of peritoneal dialysis therapy
spellingShingle Peritoneal microbiome in end-stage renal disease patients and the impact of peritoneal dialysis therapy
Simões-Silva, Liliana
microbiome
peritoneum
chronic kidney disease
peritoneal dialysis
end-stage kidney disease
Science & Technology
title_short Peritoneal microbiome in end-stage renal disease patients and the impact of peritoneal dialysis therapy
title_full Peritoneal microbiome in end-stage renal disease patients and the impact of peritoneal dialysis therapy
title_fullStr Peritoneal microbiome in end-stage renal disease patients and the impact of peritoneal dialysis therapy
title_full_unstemmed Peritoneal microbiome in end-stage renal disease patients and the impact of peritoneal dialysis therapy
title_sort Peritoneal microbiome in end-stage renal disease patients and the impact of peritoneal dialysis therapy
author Simões-Silva, Liliana
author_facet Simões-Silva, Liliana
Araujo, Ricardo
Pestana, Manuel
Soares-Silva, Isabel
Sampaio-Maia, Benedita
author_role author
author2 Araujo, Ricardo
Pestana, Manuel
Soares-Silva, Isabel
Sampaio-Maia, Benedita
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Simões-Silva, Liliana
Araujo, Ricardo
Pestana, Manuel
Soares-Silva, Isabel
Sampaio-Maia, Benedita
dc.subject.por.fl_str_mv microbiome
peritoneum
chronic kidney disease
peritoneal dialysis
end-stage kidney disease
Science & Technology
topic microbiome
peritoneum
chronic kidney disease
peritoneal dialysis
end-stage kidney disease
Science & Technology
description The following are available online at http://www.mdpi.com/2076-2607/8/2/173/s1, Figure S1 (Rarefaction curves), Figure S2 (Relative proportion taxa for class, order, genus, and species), Figure S3 (Abundances of the genera and families between the ESRD-PD and ESRD-nonPD), Figure S4 (Alpha diversity of the peritoneum microbiome community at phylum, class, order, family, genus, species and OUT taxonomic levels calculated with Observed, Chao1, Shannon, Simpson, and Inverse Simpson indexes), Figure S5 (Beta-diversity of the peritoneum microbiome community at OTU level with Bray-Curtis, Jaccard, unweighted Unifrac, and Weighted Unifrac) and Figure S6 (Non-metric multidimensional scaling of blood and peritoneum microbiomes of non-PD and PD patients).
publishDate 2020
dc.date.none.fl_str_mv 2020-01-25
2020-01-25T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/64446
url http://hdl.handle.net/1822/64446
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Simões-Silva, L.; Araujo, R.; Pestana, M.; Soares-Silva, I.; Sampaio-Maia, B. Peritoneal Microbiome in End-Stage Renal Disease Patients and the Impact of Peritoneal Dialysis Therapy. Microorganisms 2020, 8, 173.
10.3390/microorganisms8020173
https://www.mdpi.com/2076-2607/8/2/173
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132812134055936

Registros relacionados