Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor

Detalhes bibliográficos
Autor(a) principal: Florido, M
Data de Publicação: 2004
Outros Autores: Appelberg, R
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/69097
Resumo: The infection of tumor necrosis factor (TNF)-deficient mice with low doses of the virulent Mycobacterium avium strain 25291 led to the appearance of necrotic granulomas at 93 days of infection, i.e., sooner than necrotic granulomas appeared in C57BL/6 animals. Additionally, TNF-deficient mice exhibited higher mycobacterial loads in the infected organs, had extremely exacerbated gamma interferon responses as evaluated in the sera of infected animals, and showed reduced survival. Thus, TNF is not required for granuloma necrosis.
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spelling Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factorInfecções, Medicina básicaInfections, Basic medicineThe infection of tumor necrosis factor (TNF)-deficient mice with low doses of the virulent Mycobacterium avium strain 25291 led to the appearance of necrotic granulomas at 93 days of infection, i.e., sooner than necrotic granulomas appeared in C57BL/6 animals. Additionally, TNF-deficient mice exhibited higher mycobacterial loads in the infected organs, had extremely exacerbated gamma interferon responses as evaluated in the sera of infected animals, and showed reduced survival. Thus, TNF is not required for granuloma necrosis.20042004-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/69097eng0019-956710.1128/iai.72.10.6139-6141.2004Florido, MAppelberg, Rinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:50:52Zoai:repositorio-aberto.up.pt:10216/69097Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:09:56.688211Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor
title Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor
spellingShingle Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor
Florido, M
Infecções, Medicina básica
Infections, Basic medicine
title_short Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor
title_full Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor
title_fullStr Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor
title_full_unstemmed Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor
title_sort Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor
author Florido, M
author_facet Florido, M
Appelberg, R
author_role author
author2 Appelberg, R
author2_role author
dc.contributor.author.fl_str_mv Florido, M
Appelberg, R
dc.subject.por.fl_str_mv Infecções, Medicina básica
Infections, Basic medicine
topic Infecções, Medicina básica
Infections, Basic medicine
description The infection of tumor necrosis factor (TNF)-deficient mice with low doses of the virulent Mycobacterium avium strain 25291 led to the appearance of necrotic granulomas at 93 days of infection, i.e., sooner than necrotic granulomas appeared in C57BL/6 animals. Additionally, TNF-deficient mice exhibited higher mycobacterial loads in the infected organs, had extremely exacerbated gamma interferon responses as evaluated in the sera of infected animals, and showed reduced survival. Thus, TNF is not required for granuloma necrosis.
publishDate 2004
dc.date.none.fl_str_mv 2004
2004-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/69097
url https://hdl.handle.net/10216/69097
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0019-9567
10.1128/iai.72.10.6139-6141.2004
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
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