Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/21073 |
Resumo: | Schizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that is responsible for the production of most of the cerebrospinal fluid (CSF). Enlarged brain ventricles are already present at the time of disease onset (young adulthood) and, of notice, isolated mild ventriculomegaly detected in utero is associated with subsequent mild neurodevelopmental abnormalities similar to those observed in children at high risk of developing schizophrenia. Here we propose that altered CP/CSF dynamics during neurodevelopment may be considered a risk, causative and/or participating factor for development of schizophrenia. |
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Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophreniaNeurodevelopmentChoroid plexusSchizophreniaCerebrospinal fluidBrain ventriclesVentriculomegalyScience & TechnologySchizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that is responsible for the production of most of the cerebrospinal fluid (CSF). Enlarged brain ventricles are already present at the time of disease onset (young adulthood) and, of notice, isolated mild ventriculomegaly detected in utero is associated with subsequent mild neurodevelopmental abnormalities similar to those observed in children at high risk of developing schizophrenia. Here we propose that altered CP/CSF dynamics during neurodevelopment may be considered a risk, causative and/or participating factor for development of schizophrenia.Nadine C. Santos and Fernanda Marques are recipients of postdoctoral fellowships by the Switchbox project (European Commission FP7 initiative grant HEALTH-F2-2010-259772) and the Fundação para a Ciência e Tecnologia (FCT, Portugal), respectively.Frontiers MediaUniversidade do MinhoPalha, Joana AlmeidaSantos, Nadine CorreiaMarques, Fernanda Cristina Gomes de SousaSousa, JoãoBessa, JoãoMiguelote, RuiSousa, NunoBelmonte-de-Abreu, Paulo2012-082012-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/21073eng1662-510210.3389/fncel.2012.00031http://www.frontiersin.org/Cellular_Neuroscience/10.3389/fncel.2012.00031/abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:35:05Zoai:repositorium.sdum.uminho.pt:1822/21073Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:30:52.944185Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia |
title |
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia |
spellingShingle |
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia Palha, Joana Almeida Neurodevelopment Choroid plexus Schizophrenia Cerebrospinal fluid Brain ventricles Ventriculomegaly Science & Technology |
title_short |
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia |
title_full |
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia |
title_fullStr |
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia |
title_full_unstemmed |
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia |
title_sort |
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia |
author |
Palha, Joana Almeida |
author_facet |
Palha, Joana Almeida Santos, Nadine Correia Marques, Fernanda Cristina Gomes de Sousa Sousa, João Bessa, João Miguelote, Rui Sousa, Nuno Belmonte-de-Abreu, Paulo |
author_role |
author |
author2 |
Santos, Nadine Correia Marques, Fernanda Cristina Gomes de Sousa Sousa, João Bessa, João Miguelote, Rui Sousa, Nuno Belmonte-de-Abreu, Paulo |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Palha, Joana Almeida Santos, Nadine Correia Marques, Fernanda Cristina Gomes de Sousa Sousa, João Bessa, João Miguelote, Rui Sousa, Nuno Belmonte-de-Abreu, Paulo |
dc.subject.por.fl_str_mv |
Neurodevelopment Choroid plexus Schizophrenia Cerebrospinal fluid Brain ventricles Ventriculomegaly Science & Technology |
topic |
Neurodevelopment Choroid plexus Schizophrenia Cerebrospinal fluid Brain ventricles Ventriculomegaly Science & Technology |
description |
Schizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that is responsible for the production of most of the cerebrospinal fluid (CSF). Enlarged brain ventricles are already present at the time of disease onset (young adulthood) and, of notice, isolated mild ventriculomegaly detected in utero is associated with subsequent mild neurodevelopmental abnormalities similar to those observed in children at high risk of developing schizophrenia. Here we propose that altered CP/CSF dynamics during neurodevelopment may be considered a risk, causative and/or participating factor for development of schizophrenia. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-08 2012-08-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/21073 |
url |
http://hdl.handle.net/1822/21073 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1662-5102 10.3389/fncel.2012.00031 http://www.frontiersin.org/Cellular_Neuroscience/10.3389/fncel.2012.00031/abstract |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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