Ambient air pollution and lipid profile: Systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Gaio, Vânia
Data de Publicação: 2019
Outros Autores: Roquette, Rita, Dias, Carlos Matias, Nunes, Baltazar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/7348
Resumo: Meta-Analysis
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spelling Ambient air pollution and lipid profile: Systematic review and meta-analysisAir PollutionBlood LipidsLipid ProfileAmbient Air PollutionMeta-analysisSystematic ReviewEstados de Saúde e de DoençaINSEF 2015Meta-AnalysisAmbient air pollution (AAP) is recognized a cardiovascular risk factor and lipid profile dysregulation seems to be one of the potential mediators involved. However, results from epidemiologic research on the association between exposure to AAP and altered lipid profile have been inconsistent. This study aims to systematically review and meta-analyse epidemiologic evidence on the association between exposure to ambient air pollutants (particulate matter, nitrogen oxides, sulphur dioxide, ozone, carbon monoxide, back carbon) and lipid profile parameters (Total cholesterol; High-Density Lipoprotein Cholesterol; Low-Density Lipoprotein Cholesterol; TG-Triglycerides) or dyslipidaemia. Systematic electronic literature search was performed in PubMed, Web of Science and Scopus databases (last search on 24th May 2019) using keywords related to the exposure (ambient air pollutants) and to the outcomes (lipid profile parameters/dyslipidaemia). Qualitative and quantitative information of the studies were extracted and fixed or random-effects models were used to obtain a pooled effect estimate per each pollutant/outcome combination. 22 studies were qualitatively analysed and, from those, 3 studies were quantitatively analysed. Particulate matters were the most studied pollutants and a considerable heterogeneity in air pollution assessment methods and outcomes definitions was detected. Age, obesity related measures, tobacco consumption, sex and socioeconomic factors were the most frequent considered variables for confounding adjustment in the models. In a long-term exposure scenario, we found a 3.14% (1.36%-4.95%) increase in TG levels per 10 μg/m3 PM10 increment and a 4.24% (1.37%-7.19%) increase in TG levels per 10 μg/m3 NO2 increment. No significant associations were detected for the remaining pollutant/outcome combinations. Despite the few studies included in the meta-analysis, our study suggests some epidemiologic evidence supporting the association between PM10 and NO2 exposures and increased TG levels. Due to the very low level of evidence, more studies are needed to clarify the role of lipid profile dysregulation as a mediator on the AAP adverse cardiovascular effects.INSEF was developed as part of the Predefined project financed under the Public Health Initiatives Program, ‘‘Improvement of epidemiological health information to support public health decision and management in Portugal. Towards reduced inequalities, improved health, and bilateral cooperation”, with a 1.500.000V Grant from Iceland, Liechtenstein and Norway from EEA Grants and the Portuguese Government. The present study was also funded by the Portuguese Foundation for Science and Technology (FCT) (PhD Scholarship Reference: SFRH/ BD/129426/2017).ElsevierRepositório Científico do Instituto Nacional de SaúdeGaio, VâniaRoquette, RitaDias, Carlos MatiasNunes, Baltazar2021-09-30T00:30:11Z2019-112019-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7348engEnviron Pollut. 2019 Nov;254(Pt B):113036. doi: 10.1016/j.envpol.2019.113036. Epub 2019 Aug 9.0269-749110.1016/j.envpol.2019.113036info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:28Zoai:repositorio.insa.pt:10400.18/7348Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:10.805957Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ambient air pollution and lipid profile: Systematic review and meta-analysis
title Ambient air pollution and lipid profile: Systematic review and meta-analysis
spellingShingle Ambient air pollution and lipid profile: Systematic review and meta-analysis
Gaio, Vânia
Air Pollution
Blood Lipids
Lipid Profile
Ambient Air Pollution
Meta-analysis
Systematic Review
Estados de Saúde e de Doença
INSEF 2015
title_short Ambient air pollution and lipid profile: Systematic review and meta-analysis
title_full Ambient air pollution and lipid profile: Systematic review and meta-analysis
title_fullStr Ambient air pollution and lipid profile: Systematic review and meta-analysis
title_full_unstemmed Ambient air pollution and lipid profile: Systematic review and meta-analysis
title_sort Ambient air pollution and lipid profile: Systematic review and meta-analysis
author Gaio, Vânia
author_facet Gaio, Vânia
Roquette, Rita
Dias, Carlos Matias
Nunes, Baltazar
author_role author
author2 Roquette, Rita
Dias, Carlos Matias
Nunes, Baltazar
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Gaio, Vânia
Roquette, Rita
Dias, Carlos Matias
Nunes, Baltazar
dc.subject.por.fl_str_mv Air Pollution
Blood Lipids
Lipid Profile
Ambient Air Pollution
Meta-analysis
Systematic Review
Estados de Saúde e de Doença
INSEF 2015
topic Air Pollution
Blood Lipids
Lipid Profile
Ambient Air Pollution
Meta-analysis
Systematic Review
Estados de Saúde e de Doença
INSEF 2015
description Meta-Analysis
publishDate 2019
dc.date.none.fl_str_mv 2019-11
2019-11-01T00:00:00Z
2021-09-30T00:30:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/7348
url http://hdl.handle.net/10400.18/7348
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Environ Pollut. 2019 Nov;254(Pt B):113036. doi: 10.1016/j.envpol.2019.113036. Epub 2019 Aug 9.
0269-7491
10.1016/j.envpol.2019.113036
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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