Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/87519 |
Resumo: | Purpose: To evaluate the influence of defocus and pupil size on subjective (visual acuity [VA]) and objective (electrophysiology) descriptors of human vision and their effect on binocular visual performance by means of neural binocular summation (BS). Methods: Fifteen healthy young subjects were recruited in this crossover study. Pattern electroretinogram (PERG) and visual evoked potentials (VEP) were measured under two levels of positive (+1.5 and +3.0 D) spherical and astigmatic defocus (axis 90°). Pupil size was controlled to reduce the inter-individual variability factor. Results: Low- and high-contrast VA showed poorer visual performance in the monocular versus the binocular condition. Positive BS (for VA) was higher with greater pupil size and higher levels of defocus. In the visual electrophysiology tests (i.e., VEP and PERG), peak time and amplitude were affected by pupil size and defocus. The increase in peak time was larger and the reduction in amplitude was more significant with greater levels of defocus and smaller pupil sizes. For the VEP, positive BS was found in all conditions, being stronger with larger amounts of defocus and pupil size (for the P100 amplitude). Significant negative correlations were observed between the P100 amplitude and VA BSs. Conclusion: Smaller pupil size and levels of defocus produced greater changes in cortical activity as evidenced by both the PERG and VEP. Considering these changes and the obtained positive BS, the mechanism could be initiated as early as the retinal processing stage, then being modulated and enhanced along the visual pathway and within the visual cortex. |
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Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizesbinocular summationdefocuselectroretinogrampupil sizevisual evoked potentialCiências Naturais::Ciências FísicasSaúde de qualidadePurpose: To evaluate the influence of defocus and pupil size on subjective (visual acuity [VA]) and objective (electrophysiology) descriptors of human vision and their effect on binocular visual performance by means of neural binocular summation (BS). Methods: Fifteen healthy young subjects were recruited in this crossover study. Pattern electroretinogram (PERG) and visual evoked potentials (VEP) were measured under two levels of positive (+1.5 and +3.0 D) spherical and astigmatic defocus (axis 90°). Pupil size was controlled to reduce the inter-individual variability factor. Results: Low- and high-contrast VA showed poorer visual performance in the monocular versus the binocular condition. Positive BS (for VA) was higher with greater pupil size and higher levels of defocus. In the visual electrophysiology tests (i.e., VEP and PERG), peak time and amplitude were affected by pupil size and defocus. The increase in peak time was larger and the reduction in amplitude was more significant with greater levels of defocus and smaller pupil sizes. For the VEP, positive BS was found in all conditions, being stronger with larger amounts of defocus and pupil size (for the P100 amplitude). Significant negative correlations were observed between the P100 amplitude and VA BSs. Conclusion: Smaller pupil size and levels of defocus produced greater changes in cortical activity as evidenced by both the PERG and VEP. Considering these changes and the obtained positive BS, the mechanism could be initiated as early as the retinal processing stage, then being modulated and enhanced along the visual pathway and within the visual cortex.Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Grant/Award Number: A-FQM-532-UGR20; Fundação para a Ciência e a Tecnologia, Grant/Award Number: PTDC/SAU-BEB/098391/2008, PTDC/FIS-OPT/0677/2014 and UID/FIS/04650/2019WileyUniversidade do MinhoMartino, FrancescoAmorim-de-Sousa, AnaFernandes, PauloCastro-Torres, José JuanGonzález-Méijome, José Manuel2023-112023-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/87519engMartino, F., Amorim‐de‐Sousa, A., Fernandes, P., Castro‐Torres, J. J., & González‐Méijome, J. M. (2023, July 22). Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes. Ophthalmic and Physiological Optics. Wiley. http://doi.org/10.1111/opo.132040275-54081475-131310.1111/opo.13204https://onlinelibrary.wiley.com/doi/10.1111/opo.13204info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-16T01:19:54Zoai:repositorium.sdum.uminho.pt:1822/87519Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:54:21.333852Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes |
title |
Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes |
spellingShingle |
Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes Martino, Francesco binocular summation defocus electroretinogram pupil size visual evoked potential Ciências Naturais::Ciências Físicas Saúde de qualidade |
title_short |
Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes |
title_full |
Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes |
title_fullStr |
Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes |
title_full_unstemmed |
Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes |
title_sort |
Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes |
author |
Martino, Francesco |
author_facet |
Martino, Francesco Amorim-de-Sousa, Ana Fernandes, Paulo Castro-Torres, José Juan González-Méijome, José Manuel |
author_role |
author |
author2 |
Amorim-de-Sousa, Ana Fernandes, Paulo Castro-Torres, José Juan González-Méijome, José Manuel |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Martino, Francesco Amorim-de-Sousa, Ana Fernandes, Paulo Castro-Torres, José Juan González-Méijome, José Manuel |
dc.subject.por.fl_str_mv |
binocular summation defocus electroretinogram pupil size visual evoked potential Ciências Naturais::Ciências Físicas Saúde de qualidade |
topic |
binocular summation defocus electroretinogram pupil size visual evoked potential Ciências Naturais::Ciências Físicas Saúde de qualidade |
description |
Purpose: To evaluate the influence of defocus and pupil size on subjective (visual acuity [VA]) and objective (electrophysiology) descriptors of human vision and their effect on binocular visual performance by means of neural binocular summation (BS). Methods: Fifteen healthy young subjects were recruited in this crossover study. Pattern electroretinogram (PERG) and visual evoked potentials (VEP) were measured under two levels of positive (+1.5 and +3.0 D) spherical and astigmatic defocus (axis 90°). Pupil size was controlled to reduce the inter-individual variability factor. Results: Low- and high-contrast VA showed poorer visual performance in the monocular versus the binocular condition. Positive BS (for VA) was higher with greater pupil size and higher levels of defocus. In the visual electrophysiology tests (i.e., VEP and PERG), peak time and amplitude were affected by pupil size and defocus. The increase in peak time was larger and the reduction in amplitude was more significant with greater levels of defocus and smaller pupil sizes. For the VEP, positive BS was found in all conditions, being stronger with larger amounts of defocus and pupil size (for the P100 amplitude). Significant negative correlations were observed between the P100 amplitude and VA BSs. Conclusion: Smaller pupil size and levels of defocus produced greater changes in cortical activity as evidenced by both the PERG and VEP. Considering these changes and the obtained positive BS, the mechanism could be initiated as early as the retinal processing stage, then being modulated and enhanced along the visual pathway and within the visual cortex. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11 2023-11-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/87519 |
url |
https://hdl.handle.net/1822/87519 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Martino, F., Amorim‐de‐Sousa, A., Fernandes, P., Castro‐Torres, J. J., & González‐Méijome, J. M. (2023, July 22). Neural binocular summation and the effect of defocus on the pattern electroretinogram and visual evoked potentials for different pupil sizes. Ophthalmic and Physiological Optics. Wiley. http://doi.org/10.1111/opo.13204 0275-5408 1475-1313 10.1111/opo.13204 https://onlinelibrary.wiley.com/doi/10.1111/opo.13204 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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