Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/3017 |
Resumo: | Tractography studies for pre-surgical planning of primary brain tumors is typically done using diffusion tensor imaging (DTI), which cannot resolve crossing, kissing or highly angulated fibres. Tractography based on the estimation of the diffusion kurtosis (DK) tensor was recently demonstrated to enable tackling these limitations. However, its use in the clinical context at low 1.5T field has not yet been reported. PURPOSE: To evaluate if the estimation of whole-brain tractography using the DK tensor is feasible for pre-surgical investigation of patients with brain tumors at 1.5T. METHODS: Eight healthy subjects and 3 patients with brain tumors were scanned at 1.5T using a 12-channel head coil. Diffusion-weighted images were acquired with repetition/echo times of 5800/107 ms, 82 × 82 resolution, 3 × 3 × 3 mm3 voxel size, b-values of 0, 1000, 2000 s/mm2 and 64 gradient sensitising directions. Whole-brain tractography was estimated using the DK tensor and corticospinal tracts (CST) were isolated using regions-of-interest placed at the cerebral peduncles and motor gyrus. Tract size, DK metrics and CST deviation index (highest curvature point) were compared between healthy subjects and patients. RESULTS: Tract sizes did not differ between groups. The CST deviation index was significantly higher in patients compared to healthy subjects. Fractional anisotropy was significantly lower in patients, with higher mean kurtosis asymmetry index at the highest curvature point in patients. CONCLUSIONS: Corticospinal fibre bundles estimated using DK tensor in a 1.5T scanner presented similar properties in patients with brain gliomas as those reported in the literature using DTI-based tractography. |
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Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with GliomasCHLC NRADBrain TumorCorticospinal TractDeviation IndexDiffusion Kurtosis ImagingDiffusion Tensor ImagingDiffusion-Weighted ImagesDiffusion Kurtosis ImagingFractional AnisotropyMagnetic Resonance ImagingStandard DeviationTractographyTractography studies for pre-surgical planning of primary brain tumors is typically done using diffusion tensor imaging (DTI), which cannot resolve crossing, kissing or highly angulated fibres. Tractography based on the estimation of the diffusion kurtosis (DK) tensor was recently demonstrated to enable tackling these limitations. However, its use in the clinical context at low 1.5T field has not yet been reported. PURPOSE: To evaluate if the estimation of whole-brain tractography using the DK tensor is feasible for pre-surgical investigation of patients with brain tumors at 1.5T. METHODS: Eight healthy subjects and 3 patients with brain tumors were scanned at 1.5T using a 12-channel head coil. Diffusion-weighted images were acquired with repetition/echo times of 5800/107 ms, 82 × 82 resolution, 3 × 3 × 3 mm3 voxel size, b-values of 0, 1000, 2000 s/mm2 and 64 gradient sensitising directions. Whole-brain tractography was estimated using the DK tensor and corticospinal tracts (CST) were isolated using regions-of-interest placed at the cerebral peduncles and motor gyrus. Tract size, DK metrics and CST deviation index (highest curvature point) were compared between healthy subjects and patients. RESULTS: Tract sizes did not differ between groups. The CST deviation index was significantly higher in patients compared to healthy subjects. Fractional anisotropy was significantly lower in patients, with higher mean kurtosis asymmetry index at the highest curvature point in patients. CONCLUSIONS: Corticospinal fibre bundles estimated using DK tensor in a 1.5T scanner presented similar properties in patients with brain gliomas as those reported in the literature using DTI-based tractography.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPELeote, JNunes, RCerqueira, LLoução, RFerreira, H2018-08-07T10:06:13Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3017engEur J Radiol Open. 2018 Jan 28;5:20-23.10.1016/j.ejro.2018.01.002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:40:50Zoai:repositorio.chlc.min-saude.pt:10400.17/3017Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:19.700386Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas |
title |
Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas |
spellingShingle |
Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas Leote, J CHLC NRAD Brain Tumor Corticospinal Tract Deviation Index Diffusion Kurtosis Imaging Diffusion Tensor Imaging Diffusion-Weighted Images Diffusion Kurtosis Imaging Fractional Anisotropy Magnetic Resonance Imaging Standard Deviation Tractography |
title_short |
Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas |
title_full |
Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas |
title_fullStr |
Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas |
title_full_unstemmed |
Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas |
title_sort |
Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas |
author |
Leote, J |
author_facet |
Leote, J Nunes, R Cerqueira, L Loução, R Ferreira, H |
author_role |
author |
author2 |
Nunes, R Cerqueira, L Loução, R Ferreira, H |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Leote, J Nunes, R Cerqueira, L Loução, R Ferreira, H |
dc.subject.por.fl_str_mv |
CHLC NRAD Brain Tumor Corticospinal Tract Deviation Index Diffusion Kurtosis Imaging Diffusion Tensor Imaging Diffusion-Weighted Images Diffusion Kurtosis Imaging Fractional Anisotropy Magnetic Resonance Imaging Standard Deviation Tractography |
topic |
CHLC NRAD Brain Tumor Corticospinal Tract Deviation Index Diffusion Kurtosis Imaging Diffusion Tensor Imaging Diffusion-Weighted Images Diffusion Kurtosis Imaging Fractional Anisotropy Magnetic Resonance Imaging Standard Deviation Tractography |
description |
Tractography studies for pre-surgical planning of primary brain tumors is typically done using diffusion tensor imaging (DTI), which cannot resolve crossing, kissing or highly angulated fibres. Tractography based on the estimation of the diffusion kurtosis (DK) tensor was recently demonstrated to enable tackling these limitations. However, its use in the clinical context at low 1.5T field has not yet been reported. PURPOSE: To evaluate if the estimation of whole-brain tractography using the DK tensor is feasible for pre-surgical investigation of patients with brain tumors at 1.5T. METHODS: Eight healthy subjects and 3 patients with brain tumors were scanned at 1.5T using a 12-channel head coil. Diffusion-weighted images were acquired with repetition/echo times of 5800/107 ms, 82 × 82 resolution, 3 × 3 × 3 mm3 voxel size, b-values of 0, 1000, 2000 s/mm2 and 64 gradient sensitising directions. Whole-brain tractography was estimated using the DK tensor and corticospinal tracts (CST) were isolated using regions-of-interest placed at the cerebral peduncles and motor gyrus. Tract size, DK metrics and CST deviation index (highest curvature point) were compared between healthy subjects and patients. RESULTS: Tract sizes did not differ between groups. The CST deviation index was significantly higher in patients compared to healthy subjects. Fractional anisotropy was significantly lower in patients, with higher mean kurtosis asymmetry index at the highest curvature point in patients. CONCLUSIONS: Corticospinal fibre bundles estimated using DK tensor in a 1.5T scanner presented similar properties in patients with brain gliomas as those reported in the literature using DTI-based tractography. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08-07T10:06:13Z 2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/3017 |
url |
http://hdl.handle.net/10400.17/3017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Eur J Radiol Open. 2018 Jan 28;5:20-23. 10.1016/j.ejro.2018.01.002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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