Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas

Detalhes bibliográficos
Autor(a) principal: Leote, J
Data de Publicação: 2018
Outros Autores: Nunes, R, Cerqueira, L, Loução, R, Ferreira, H
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/3017
Resumo: Tractography studies for pre-surgical planning of primary brain tumors is typically done using diffusion tensor imaging (DTI), which cannot resolve crossing, kissing or highly angulated fibres. Tractography based on the estimation of the diffusion kurtosis (DK) tensor was recently demonstrated to enable tackling these limitations. However, its use in the clinical context at low 1.5T field has not yet been reported. PURPOSE: To evaluate if the estimation of whole-brain tractography using the DK tensor is feasible for pre-surgical investigation of patients with brain tumors at 1.5T. METHODS: Eight healthy subjects and 3 patients with brain tumors were scanned at 1.5T using a 12-channel head coil. Diffusion-weighted images were acquired with repetition/echo times of 5800/107 ms, 82 × 82 resolution, 3 × 3 × 3 mm3 voxel size, b-values of 0, 1000, 2000 s/mm2 and 64 gradient sensitising directions. Whole-brain tractography was estimated using the DK tensor and corticospinal tracts (CST) were isolated using regions-of-interest placed at the cerebral peduncles and motor gyrus. Tract size, DK metrics and CST deviation index (highest curvature point) were compared between healthy subjects and patients. RESULTS: Tract sizes did not differ between groups. The CST deviation index was significantly higher in patients compared to healthy subjects. Fractional anisotropy was significantly lower in patients, with higher mean kurtosis asymmetry index at the highest curvature point in patients. CONCLUSIONS: Corticospinal fibre bundles estimated using DK tensor in a 1.5T scanner presented similar properties in patients with brain gliomas as those reported in the literature using DTI-based tractography.
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spelling Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with GliomasCHLC NRADBrain TumorCorticospinal TractDeviation IndexDiffusion Kurtosis ImagingDiffusion Tensor ImagingDiffusion-Weighted ImagesDiffusion Kurtosis ImagingFractional AnisotropyMagnetic Resonance ImagingStandard DeviationTractographyTractography studies for pre-surgical planning of primary brain tumors is typically done using diffusion tensor imaging (DTI), which cannot resolve crossing, kissing or highly angulated fibres. Tractography based on the estimation of the diffusion kurtosis (DK) tensor was recently demonstrated to enable tackling these limitations. However, its use in the clinical context at low 1.5T field has not yet been reported. PURPOSE: To evaluate if the estimation of whole-brain tractography using the DK tensor is feasible for pre-surgical investigation of patients with brain tumors at 1.5T. METHODS: Eight healthy subjects and 3 patients with brain tumors were scanned at 1.5T using a 12-channel head coil. Diffusion-weighted images were acquired with repetition/echo times of 5800/107 ms, 82 × 82 resolution, 3 × 3 × 3 mm3 voxel size, b-values of 0, 1000, 2000 s/mm2 and 64 gradient sensitising directions. Whole-brain tractography was estimated using the DK tensor and corticospinal tracts (CST) were isolated using regions-of-interest placed at the cerebral peduncles and motor gyrus. Tract size, DK metrics and CST deviation index (highest curvature point) were compared between healthy subjects and patients. RESULTS: Tract sizes did not differ between groups. The CST deviation index was significantly higher in patients compared to healthy subjects. Fractional anisotropy was significantly lower in patients, with higher mean kurtosis asymmetry index at the highest curvature point in patients. CONCLUSIONS: Corticospinal fibre bundles estimated using DK tensor in a 1.5T scanner presented similar properties in patients with brain gliomas as those reported in the literature using DTI-based tractography.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPELeote, JNunes, RCerqueira, LLoução, RFerreira, H2018-08-07T10:06:13Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3017engEur J Radiol Open. 2018 Jan 28;5:20-23.10.1016/j.ejro.2018.01.002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:40:50Zoai:repositorio.chlc.min-saude.pt:10400.17/3017Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:19.700386Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas
title Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas
spellingShingle Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas
Leote, J
CHLC NRAD
Brain Tumor
Corticospinal Tract
Deviation Index
Diffusion Kurtosis Imaging
Diffusion Tensor Imaging
Diffusion-Weighted Images
Diffusion Kurtosis Imaging
Fractional Anisotropy
Magnetic Resonance Imaging
Standard Deviation
Tractography
title_short Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas
title_full Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas
title_fullStr Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas
title_full_unstemmed Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas
title_sort Reconstruction of White Matter Fibre Tracts Using Diffusion Kurtosis Tensor Imaging at 1.5T: Pre-Surgical Planning in Patients with Gliomas
author Leote, J
author_facet Leote, J
Nunes, R
Cerqueira, L
Loução, R
Ferreira, H
author_role author
author2 Nunes, R
Cerqueira, L
Loução, R
Ferreira, H
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Leote, J
Nunes, R
Cerqueira, L
Loução, R
Ferreira, H
dc.subject.por.fl_str_mv CHLC NRAD
Brain Tumor
Corticospinal Tract
Deviation Index
Diffusion Kurtosis Imaging
Diffusion Tensor Imaging
Diffusion-Weighted Images
Diffusion Kurtosis Imaging
Fractional Anisotropy
Magnetic Resonance Imaging
Standard Deviation
Tractography
topic CHLC NRAD
Brain Tumor
Corticospinal Tract
Deviation Index
Diffusion Kurtosis Imaging
Diffusion Tensor Imaging
Diffusion-Weighted Images
Diffusion Kurtosis Imaging
Fractional Anisotropy
Magnetic Resonance Imaging
Standard Deviation
Tractography
description Tractography studies for pre-surgical planning of primary brain tumors is typically done using diffusion tensor imaging (DTI), which cannot resolve crossing, kissing or highly angulated fibres. Tractography based on the estimation of the diffusion kurtosis (DK) tensor was recently demonstrated to enable tackling these limitations. However, its use in the clinical context at low 1.5T field has not yet been reported. PURPOSE: To evaluate if the estimation of whole-brain tractography using the DK tensor is feasible for pre-surgical investigation of patients with brain tumors at 1.5T. METHODS: Eight healthy subjects and 3 patients with brain tumors were scanned at 1.5T using a 12-channel head coil. Diffusion-weighted images were acquired with repetition/echo times of 5800/107 ms, 82 × 82 resolution, 3 × 3 × 3 mm3 voxel size, b-values of 0, 1000, 2000 s/mm2 and 64 gradient sensitising directions. Whole-brain tractography was estimated using the DK tensor and corticospinal tracts (CST) were isolated using regions-of-interest placed at the cerebral peduncles and motor gyrus. Tract size, DK metrics and CST deviation index (highest curvature point) were compared between healthy subjects and patients. RESULTS: Tract sizes did not differ between groups. The CST deviation index was significantly higher in patients compared to healthy subjects. Fractional anisotropy was significantly lower in patients, with higher mean kurtosis asymmetry index at the highest curvature point in patients. CONCLUSIONS: Corticospinal fibre bundles estimated using DK tensor in a 1.5T scanner presented similar properties in patients with brain gliomas as those reported in the literature using DTI-based tractography.
publishDate 2018
dc.date.none.fl_str_mv 2018-08-07T10:06:13Z
2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3017
url http://hdl.handle.net/10400.17/3017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur J Radiol Open. 2018 Jan 28;5:20-23.
10.1016/j.ejro.2018.01.002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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