Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria

Detalhes bibliográficos
Autor(a) principal: Ferraz, Ricardo
Data de Publicação: 2013
Outros Autores: Teixeira, Vânia, Rodrigues, Débora, Prudêncio, Cristina, Fernandes, Rúben, Noronha, João Paulo, Petrovski, Zeljko, Branco, Luís
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/5525
Resumo: Antibacterial activity of novel Active Pharmaceutical Ingredient Ionic Liquids (API-ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties on some sensitive bacteria and especially some Gram-negative resistant bacteria when compared to the [Na][Amp] and the initial bromide and chloride salts. For these studies were analysed the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBIC) against sensitive Gram-negative bacteria Escherichia coli ATCC 25922 and Klebsiella pneumonia (clinically isolated), as well as sensitive Gram positive S. Aureus ATCC 25923, Staphylococcus epidermidis and Enterococcus faecalis and completed using clinically isolated resistent strains: E. coli TEM CTX M9, E. coli CTX M2 and E. coli AmpC Mox. From the obtained MIC values of studied APIs-ILs and standard [Na][Amp] were derived RDIC values (relative decrease of inhibitory concentration). High RDIC values of [C16Pyr][Amp] especially against two resistant Gram-negative strains E. coli TEM CTX M9 (RDIC>1000) and E. coli CTX M2 (RDIC>100) point clearly to a potential promising role of APIs-ILs as antimicrobial drugs especially against resistant bacterial strains.
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spelling Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteriaAntibacterial activity of novel Active Pharmaceutical Ingredient Ionic Liquids (API-ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties on some sensitive bacteria and especially some Gram-negative resistant bacteria when compared to the [Na][Amp] and the initial bromide and chloride salts. For these studies were analysed the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBIC) against sensitive Gram-negative bacteria Escherichia coli ATCC 25922 and Klebsiella pneumonia (clinically isolated), as well as sensitive Gram positive S. Aureus ATCC 25923, Staphylococcus epidermidis and Enterococcus faecalis and completed using clinically isolated resistent strains: E. coli TEM CTX M9, E. coli CTX M2 and E. coli AmpC Mox. From the obtained MIC values of studied APIs-ILs and standard [Na][Amp] were derived RDIC values (relative decrease of inhibitory concentration). High RDIC values of [C16Pyr][Amp] especially against two resistant Gram-negative strains E. coli TEM CTX M9 (RDIC>1000) and E. coli CTX M2 (RDIC>100) point clearly to a potential promising role of APIs-ILs as antimicrobial drugs especially against resistant bacterial strains.Royal Society of ChemistryRepositório Científico do Instituto Politécnico do PortoFerraz, RicardoTeixeira, VâniaRodrigues, DéboraPrudêncio, CristinaFernandes, RúbenNoronha, João PauloPetrovski, ZeljkoBranco, Luís2015-01-29T16:48:51Z2013-11-062013-11-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/5525eng10.1039/c3ra44286ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:45:27Zoai:recipp.ipp.pt:10400.22/5525Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:26:03.111896Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria
title Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria
spellingShingle Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria
Ferraz, Ricardo
title_short Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria
title_full Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria
title_fullStr Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria
title_full_unstemmed Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria
title_sort Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria
author Ferraz, Ricardo
author_facet Ferraz, Ricardo
Teixeira, Vânia
Rodrigues, Débora
Prudêncio, Cristina
Fernandes, Rúben
Noronha, João Paulo
Petrovski, Zeljko
Branco, Luís
author_role author
author2 Teixeira, Vânia
Rodrigues, Débora
Prudêncio, Cristina
Fernandes, Rúben
Noronha, João Paulo
Petrovski, Zeljko
Branco, Luís
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Ferraz, Ricardo
Teixeira, Vânia
Rodrigues, Débora
Prudêncio, Cristina
Fernandes, Rúben
Noronha, João Paulo
Petrovski, Zeljko
Branco, Luís
description Antibacterial activity of novel Active Pharmaceutical Ingredient Ionic Liquids (API-ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties on some sensitive bacteria and especially some Gram-negative resistant bacteria when compared to the [Na][Amp] and the initial bromide and chloride salts. For these studies were analysed the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBIC) against sensitive Gram-negative bacteria Escherichia coli ATCC 25922 and Klebsiella pneumonia (clinically isolated), as well as sensitive Gram positive S. Aureus ATCC 25923, Staphylococcus epidermidis and Enterococcus faecalis and completed using clinically isolated resistent strains: E. coli TEM CTX M9, E. coli CTX M2 and E. coli AmpC Mox. From the obtained MIC values of studied APIs-ILs and standard [Na][Amp] were derived RDIC values (relative decrease of inhibitory concentration). High RDIC values of [C16Pyr][Amp] especially against two resistant Gram-negative strains E. coli TEM CTX M9 (RDIC>1000) and E. coli CTX M2 (RDIC>100) point clearly to a potential promising role of APIs-ILs as antimicrobial drugs especially against resistant bacterial strains.
publishDate 2013
dc.date.none.fl_str_mv 2013-11-06
2013-11-06T00:00:00Z
2015-01-29T16:48:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/5525
url http://hdl.handle.net/10400.22/5525
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1039/c3ra44286a
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dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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