Epidemiological Profile in Portugal of Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cross-Sectional Study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055 |
Resumo: | Introduction: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell neoplasm that is predominantly associated with the use of textured implants. Recently, several countries have tried to clarify their epidemiological profile of BIA-ALCL. This study aims to estimate the number of cases of BIA-ALCL in Portugal and to describe the pattern of use of breast implants at a national level.Material and Methods: This is a cross-sectional study including 57 healthcare institutions - 29 public hospitals and 28 private institutions. Each department of Plastic, Reconstructive and Aesthetic Surgery was asked to provide information concerning the main manufacturer(s) and respective device texture of the breast implants used, and to report the number of registered cases of BIA-ALCL.Results: In our study sample, the response rate was 58%. In our sample, most hospitals reported using textured breast implants from Mentor (45.45%), Allergan (42.42%) and Polytech (39.39%). Only one private institution referred using smooth-coated implants from Mentor and Motiva. Despite several hospitals reporting late-onset seromas, there was only one confirmed case of BIA-ALCL after proper investigation with immunohistochemistry and histological procedures.Discussion: BIA-ALCL may represent a shift for surgeons regarding selection of implant type. Smooth-coated implants or autologous tissue represent adequate alternatives that could surpass the risks associated with textured devices.Conclusion: In the future, the creation of a national patient registry and proper recognition of BIA-ALCL by plastic surgeons could be useful tools to clarify the impact of the disease nationally and to mitigate potential risk factors. |
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Epidemiological Profile in Portugal of Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cross-Sectional StudyPerfil Epidemiológico em Portugal do Linfoma Anaplásico de Grandes Células Associado a Implantes Mamários: Um Estudo TransversalBreast Implants/adverse effectsLymphomaLarge-CellAnaplastic/epidemiologyAnaplastic/etiologyPortugalImplantes Mamários/efeitos adversosLinfoma Anaplásico Cutâneo Primário de Células Grandes/epidemiologiaLinfoma Anaplásico Cutâneo Primário de Células Grandes/etiologiaPortugalIntroduction: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell neoplasm that is predominantly associated with the use of textured implants. Recently, several countries have tried to clarify their epidemiological profile of BIA-ALCL. This study aims to estimate the number of cases of BIA-ALCL in Portugal and to describe the pattern of use of breast implants at a national level.Material and Methods: This is a cross-sectional study including 57 healthcare institutions - 29 public hospitals and 28 private institutions. Each department of Plastic, Reconstructive and Aesthetic Surgery was asked to provide information concerning the main manufacturer(s) and respective device texture of the breast implants used, and to report the number of registered cases of BIA-ALCL.Results: In our study sample, the response rate was 58%. In our sample, most hospitals reported using textured breast implants from Mentor (45.45%), Allergan (42.42%) and Polytech (39.39%). Only one private institution referred using smooth-coated implants from Mentor and Motiva. Despite several hospitals reporting late-onset seromas, there was only one confirmed case of BIA-ALCL after proper investigation with immunohistochemistry and histological procedures.Discussion: BIA-ALCL may represent a shift for surgeons regarding selection of implant type. Smooth-coated implants or autologous tissue represent adequate alternatives that could surpass the risks associated with textured devices.Conclusion: In the future, the creation of a national patient registry and proper recognition of BIA-ALCL by plastic surgeons could be useful tools to clarify the impact of the disease nationally and to mitigate potential risk factors.Introdução: O linfoma anaplásico de grandes células associado a implantes mamários (BIA-ALCL) é uma neoplasia rara de células T predominantemente associada ao uso de próteses texturizadas. Recentemente, vários países procuraram clarificar o seu perfil epidemiológico. Este estudo pretende estimar o número de casos de BIA-ALCL em Portugal e descrever o padrão de utilização de próteses mamárias a nível nacional.Material e Métodos: Este é um estudo transversal realizado em 57 serviços de saúde - 29 hospitais públicos e 28 instituições privadas. A cada departamento de Cirurgia Plástica, Reconstrutiva e Estética foi solicitada informação sobre os principais fabricantes e respetiva textura dos implantes mamários utilizados, bem como número de casos registados de BIA-ALCL.Resultados: Na nossa amostra, a taxa de resposta foi 58%. Considerando o universo de respostas obtidas, a maioria dos hospitais referiu usar implantes mamários texturizados da Mentor (45,45%), Allergan (42,42%) e Polytech (39,39%). Apenas uma instituição privada mencionou utilizar implantes lisos da Mentor e Motiva. Vários hospitais reportaram a ocorrência de seromas tardios. Contudo, apenas um caso de BIA-ALCL se veio a confirmar após investigação imunohistoquímica e histológica adequada.Discussão: O BIA-ALCL poderá determinar uma alteração do paradigma de seleção do tipo de implante mamário, onde alternativas como os implantes lisos e tecido autólogo poderão superar os riscos inerentes aos dispositivos texturizados.Conclusão: De futuro, a criação de um registo nacional de doentes e reconhecimento do BIA-ALCL pelos cirurgiões plásticos poderão ser importantes ferramentas para clarificar o seu impacto no território nacional e mitigar potenciais fatores de risco.Ordem dos Médicos2021-08-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/tiffapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055oai:ojs.www.actamedicaportuguesa.com:article/14055Acta Médica Portuguesa; Vol. 34 No. 9 (2021): September; 572-579Acta Médica Portuguesa; Vol. 34 N.º 9 (2021): Setembro; 572-5791646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/6242https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/12557https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/12558https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/12559https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/12560https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/12622Direitos de Autor (c) 2021 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessCunha, AdrianaHorta, RicardoBarreiro, Diogo2022-12-20T11:07:06Zoai:ojs.www.actamedicaportuguesa.com:article/14055Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:26.075239Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Epidemiological Profile in Portugal of Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cross-Sectional Study Perfil Epidemiológico em Portugal do Linfoma Anaplásico de Grandes Células Associado a Implantes Mamários: Um Estudo Transversal |
title |
Epidemiological Profile in Portugal of Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cross-Sectional Study |
spellingShingle |
Epidemiological Profile in Portugal of Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cross-Sectional Study Cunha, Adriana Breast Implants/adverse effects Lymphoma Large-Cell Anaplastic/epidemiology Anaplastic/etiology Portugal Implantes Mamários/efeitos adversos Linfoma Anaplásico Cutâneo Primário de Células Grandes/epidemiologia Linfoma Anaplásico Cutâneo Primário de Células Grandes/etiologia Portugal |
title_short |
Epidemiological Profile in Portugal of Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cross-Sectional Study |
title_full |
Epidemiological Profile in Portugal of Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cross-Sectional Study |
title_fullStr |
Epidemiological Profile in Portugal of Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cross-Sectional Study |
title_full_unstemmed |
Epidemiological Profile in Portugal of Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cross-Sectional Study |
title_sort |
Epidemiological Profile in Portugal of Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cross-Sectional Study |
author |
Cunha, Adriana |
author_facet |
Cunha, Adriana Horta, Ricardo Barreiro, Diogo |
author_role |
author |
author2 |
Horta, Ricardo Barreiro, Diogo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Cunha, Adriana Horta, Ricardo Barreiro, Diogo |
dc.subject.por.fl_str_mv |
Breast Implants/adverse effects Lymphoma Large-Cell Anaplastic/epidemiology Anaplastic/etiology Portugal Implantes Mamários/efeitos adversos Linfoma Anaplásico Cutâneo Primário de Células Grandes/epidemiologia Linfoma Anaplásico Cutâneo Primário de Células Grandes/etiologia Portugal |
topic |
Breast Implants/adverse effects Lymphoma Large-Cell Anaplastic/epidemiology Anaplastic/etiology Portugal Implantes Mamários/efeitos adversos Linfoma Anaplásico Cutâneo Primário de Células Grandes/epidemiologia Linfoma Anaplásico Cutâneo Primário de Células Grandes/etiologia Portugal |
description |
Introduction: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell neoplasm that is predominantly associated with the use of textured implants. Recently, several countries have tried to clarify their epidemiological profile of BIA-ALCL. This study aims to estimate the number of cases of BIA-ALCL in Portugal and to describe the pattern of use of breast implants at a national level.Material and Methods: This is a cross-sectional study including 57 healthcare institutions - 29 public hospitals and 28 private institutions. Each department of Plastic, Reconstructive and Aesthetic Surgery was asked to provide information concerning the main manufacturer(s) and respective device texture of the breast implants used, and to report the number of registered cases of BIA-ALCL.Results: In our study sample, the response rate was 58%. In our sample, most hospitals reported using textured breast implants from Mentor (45.45%), Allergan (42.42%) and Polytech (39.39%). Only one private institution referred using smooth-coated implants from Mentor and Motiva. Despite several hospitals reporting late-onset seromas, there was only one confirmed case of BIA-ALCL after proper investigation with immunohistochemistry and histological procedures.Discussion: BIA-ALCL may represent a shift for surgeons regarding selection of implant type. Smooth-coated implants or autologous tissue represent adequate alternatives that could surpass the risks associated with textured devices.Conclusion: In the future, the creation of a national patient registry and proper recognition of BIA-ALCL by plastic surgeons could be useful tools to clarify the impact of the disease nationally and to mitigate potential risk factors. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055 oai:ojs.www.actamedicaportuguesa.com:article/14055 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055 |
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oai:ojs.www.actamedicaportuguesa.com:article/14055 |
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eng |
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eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/6242 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/12557 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/12558 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/12559 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/12560 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14055/12622 |
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Direitos de Autor (c) 2021 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2021 Acta Médica Portuguesa |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 34 No. 9 (2021): September; 572-579 Acta Médica Portuguesa; Vol. 34 N.º 9 (2021): Setembro; 572-579 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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