Altered expression of proteins in cancer: function and potential therapeutic targets

Detalhes bibliográficos
Autor(a) principal: Pessoa, João
Data de Publicação: 2022
Outros Autores: Martins, Marta, Casimiro, Sandra, Pérez-Plasencia, Carlos, Shoshan-Barmatz, Varda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54571
Resumo: Copyright © 2022 Pessoa, Martins, Casimiro, Pérez-Plasencia and Shoshan-Barmatz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Altered expression of proteins in cancer: function and potential therapeutic targetsCancerProtein expression levelsUp-regulationDown-regulationTherapeutic targetCopyright © 2022 Pessoa, Martins, Casimiro, Pérez-Plasencia and Shoshan-Barmatz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.The design of innovative cancer treatments requires extensive characterization of the molecular and cellular alterations associated with tumor development and progression. Cancer cells show extensive alterations in protein expression levels, which are drivers of their malignant transformation. Proteins with altered expression levels in cancer are involved in protein synthesis and degradation, signaling and metabolic pathways, DNA repair, apoptosis, and other cellular processes, whose alterations cause tumor development and progression. Characterizing the mechanisms that lead to alterations in protein levels and their cellular effects is an invaluable tool for repurposing those proteins as drug targets. Examples of up-regulated proteins in cancer include the epidermal growth factor receptor 2 (HER2) and the vascular endothelial growth factor (VEGF). HER2 is up-regulated in several cancer types, including breast, gastroesophageal, and non-small-cell lung cancers, making it an effective drug target. VEGF is up-regulated in pancreatic, prostate, and colorectal cancers, among others. Its inhibition is also an effective anticancer treatment, through a decrease in tumor vascularization.These examples demonstrate the modulation of protein levels as an effective anticancer target, which is becoming widely used in patient treatments. These studies also encourage additional research to uncover and test novel up-/down-regulated proteins as potential new therapeutic targets.This work was financed by the European Regional Development Fund (ERDF), through the COMPETE 2020 – Operational Programme for Competitiveness and Internationalization and Portuguese national funds via FCT – Fundação para a Ciência e a Tecnologia, under the projects POCI-01-0145-FEDER-028147 (VISCERAL), UIDB/04539/2020, UIDP/04539/2020, and LA/P/0058/2020 (to JP), and PTDC/MED-ONC/28636/2017 (to SC); by Programa de Financiamiento para la Investigación, UNAM, PAPIIT-IN231420, México (to CP-P); and by the National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer Sheva, Israel (to VS-B).FrontiersRepositório da Universidade de LisboaPessoa, JoãoMartins, MartaCasimiro, SandraPérez-Plasencia, CarlosShoshan-Barmatz, Varda2022-09-23T13:53:18Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54571engFront Oncol. 2022 Jun 22;12:94913910.3389/fonc.2022.9491392234-943Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:02Zoai:repositorio.ul.pt:10451/54571Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:23.088357Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Altered expression of proteins in cancer: function and potential therapeutic targets
title Altered expression of proteins in cancer: function and potential therapeutic targets
spellingShingle Altered expression of proteins in cancer: function and potential therapeutic targets
Pessoa, João
Cancer
Protein expression levels
Up-regulation
Down-regulation
Therapeutic target
title_short Altered expression of proteins in cancer: function and potential therapeutic targets
title_full Altered expression of proteins in cancer: function and potential therapeutic targets
title_fullStr Altered expression of proteins in cancer: function and potential therapeutic targets
title_full_unstemmed Altered expression of proteins in cancer: function and potential therapeutic targets
title_sort Altered expression of proteins in cancer: function and potential therapeutic targets
author Pessoa, João
author_facet Pessoa, João
Martins, Marta
Casimiro, Sandra
Pérez-Plasencia, Carlos
Shoshan-Barmatz, Varda
author_role author
author2 Martins, Marta
Casimiro, Sandra
Pérez-Plasencia, Carlos
Shoshan-Barmatz, Varda
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pessoa, João
Martins, Marta
Casimiro, Sandra
Pérez-Plasencia, Carlos
Shoshan-Barmatz, Varda
dc.subject.por.fl_str_mv Cancer
Protein expression levels
Up-regulation
Down-regulation
Therapeutic target
topic Cancer
Protein expression levels
Up-regulation
Down-regulation
Therapeutic target
description Copyright © 2022 Pessoa, Martins, Casimiro, Pérez-Plasencia and Shoshan-Barmatz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-23T13:53:18Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54571
url http://hdl.handle.net/10451/54571
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Oncol. 2022 Jun 22;12:949139
10.3389/fonc.2022.949139
2234-943X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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