Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/11542 |
Resumo: | Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules. Methanol extracts were thus prepared from freeze-dried biomass and screened for different biological activities. Nannochloris sp. SBL1 and Desmochloris sp. SBL3 had the highest radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl, and the best copper and iron chelating activities. All species had potent butyrylcholinesterase inhibitory activity (>50%) and mildly inhibited tyrosinase. Picochlorum sp. SBL2 and Nannochloris sp. SBL4 extracts significantly reduced the viability of tumoral (HepG2 and HeLa) cells with lower toxicity against the non-tumoral murine stromal (S17) cells. Nannochloris sp. SBL1 significantly reduced the viability of Leishmania infantum down to 62% (250 mu g/mL). Picochlorum sp. SBL2 had the highest total phenolic content, the major phenolic compounds identified being salicylic, coumaric and gallic acids. Neoxanthin, violaxanthin, zeaxanthin, lutein and -carotene were identified in the extracts of all strains, while canthaxanthin was only identified in Picochlorum sp. SBL2. Taken together, these results strongly suggest that the microalgae included in this work could be used as sources of added-value products that could be used to upgrade the final biomass value. |
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Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red SeaAlzheimers-diseaseTyrosinase inhibitorsAntioxidant activityPhenolic-CompoundsMedicinal-plantsOxidative stressHuman healthBiofuelsLeishmaniasisCarotenoidsFour lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules. Methanol extracts were thus prepared from freeze-dried biomass and screened for different biological activities. Nannochloris sp. SBL1 and Desmochloris sp. SBL3 had the highest radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl, and the best copper and iron chelating activities. All species had potent butyrylcholinesterase inhibitory activity (>50%) and mildly inhibited tyrosinase. Picochlorum sp. SBL2 and Nannochloris sp. SBL4 extracts significantly reduced the viability of tumoral (HepG2 and HeLa) cells with lower toxicity against the non-tumoral murine stromal (S17) cells. Nannochloris sp. SBL1 significantly reduced the viability of Leishmania infantum down to 62% (250 mu g/mL). Picochlorum sp. SBL2 had the highest total phenolic content, the major phenolic compounds identified being salicylic, coumaric and gallic acids. Neoxanthin, violaxanthin, zeaxanthin, lutein and -carotene were identified in the extracts of all strains, while canthaxanthin was only identified in Picochlorum sp. SBL2. Taken together, these results strongly suggest that the microalgae included in this work could be used as sources of added-value products that could be used to upgrade the final biomass value.National Science, Technology and Innovation Program of King Abdulaziz Medical City for Science and Technology, Riyadh, Saudi Arabia [NPST, 11-ENE 1719-02]; Foundation for Science and Technology (FCT), Portugal [SFRH/BD/78062/2011]; FCT [IF/00049/2012, SFRH/BPD/86071/2012, Pest-OE/QUI/UI0612/2013]MDPI AgSapientiaPereira, HugoCustodio, LuisaRodrigues, Maria JoaoBruno De Sousa, CarolinaOliveira, MartaBarreira, LuísaNeng, Nuno da RosaFlorencio Nogueira, Jose ManuelAlrokayan, Salman A.Mouffouk, FouziAbu-Salah, Khalid M.Ben-Hamadou, RadhouanVarela, João2018-12-07T14:53:29Z2015-062015-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11542eng1660-339710.3390/md13063531info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:23:22Zoai:sapientia.ualg.pt:10400.1/11542Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:03:02.152501Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea |
title |
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea |
spellingShingle |
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea Pereira, Hugo Alzheimers-disease Tyrosinase inhibitors Antioxidant activity Phenolic-Compounds Medicinal-plants Oxidative stress Human health Biofuels Leishmaniasis Carotenoids |
title_short |
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea |
title_full |
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea |
title_fullStr |
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea |
title_full_unstemmed |
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea |
title_sort |
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea |
author |
Pereira, Hugo |
author_facet |
Pereira, Hugo Custodio, Luisa Rodrigues, Maria Joao Bruno De Sousa, Carolina Oliveira, Marta Barreira, Luísa Neng, Nuno da Rosa Florencio Nogueira, Jose Manuel Alrokayan, Salman A. Mouffouk, Fouzi Abu-Salah, Khalid M. Ben-Hamadou, Radhouan Varela, João |
author_role |
author |
author2 |
Custodio, Luisa Rodrigues, Maria Joao Bruno De Sousa, Carolina Oliveira, Marta Barreira, Luísa Neng, Nuno da Rosa Florencio Nogueira, Jose Manuel Alrokayan, Salman A. Mouffouk, Fouzi Abu-Salah, Khalid M. Ben-Hamadou, Radhouan Varela, João |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Pereira, Hugo Custodio, Luisa Rodrigues, Maria Joao Bruno De Sousa, Carolina Oliveira, Marta Barreira, Luísa Neng, Nuno da Rosa Florencio Nogueira, Jose Manuel Alrokayan, Salman A. Mouffouk, Fouzi Abu-Salah, Khalid M. Ben-Hamadou, Radhouan Varela, João |
dc.subject.por.fl_str_mv |
Alzheimers-disease Tyrosinase inhibitors Antioxidant activity Phenolic-Compounds Medicinal-plants Oxidative stress Human health Biofuels Leishmaniasis Carotenoids |
topic |
Alzheimers-disease Tyrosinase inhibitors Antioxidant activity Phenolic-Compounds Medicinal-plants Oxidative stress Human health Biofuels Leishmaniasis Carotenoids |
description |
Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules. Methanol extracts were thus prepared from freeze-dried biomass and screened for different biological activities. Nannochloris sp. SBL1 and Desmochloris sp. SBL3 had the highest radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl, and the best copper and iron chelating activities. All species had potent butyrylcholinesterase inhibitory activity (>50%) and mildly inhibited tyrosinase. Picochlorum sp. SBL2 and Nannochloris sp. SBL4 extracts significantly reduced the viability of tumoral (HepG2 and HeLa) cells with lower toxicity against the non-tumoral murine stromal (S17) cells. Nannochloris sp. SBL1 significantly reduced the viability of Leishmania infantum down to 62% (250 mu g/mL). Picochlorum sp. SBL2 had the highest total phenolic content, the major phenolic compounds identified being salicylic, coumaric and gallic acids. Neoxanthin, violaxanthin, zeaxanthin, lutein and -carotene were identified in the extracts of all strains, while canthaxanthin was only identified in Picochlorum sp. SBL2. Taken together, these results strongly suggest that the microalgae included in this work could be used as sources of added-value products that could be used to upgrade the final biomass value. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06 2015-06-01T00:00:00Z 2018-12-07T14:53:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/11542 |
url |
http://hdl.handle.net/10400.1/11542 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1660-3397 10.3390/md13063531 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI Ag |
publisher.none.fl_str_mv |
MDPI Ag |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133264396419072 |