Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke

Detalhes bibliográficos
Autor(a) principal: Dias, Alexandre
Data de Publicação: 2021
Outros Autores: Silva, Isabel, Pinto, Inês Mendes, Maia, Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.16/2905
Resumo: Stroke is a leading cause of death and disability in the world. To address such a problem, early diagnosis and tailored acute treatment represent one of the major priorities in acute stroke care. Since the efficacy of reperfusion treatments is highly time-dependent, there is a critical need to optimize procedures for faster and more precise diagnosis. We provide a concise review of the most relevant and well-documented blood-protein biomarkers that exhibit greater potential for translational to clinical practice in stroke differential diagnosis and to differentiate ischemic stroke from hemorrhagic stroke, followed by an overview of the most recent point-of-care technological approaches to address this problem. The integration of fluid-based biomarker profiling, using point-of-care biosensors with demographic, clinical, and neuroimaging parameters in multi-dimensional clinical decision-making algorithms, will be the next step in personalized stroke care.
id RCAP_7060a3bd725d50462663a9ae19b6d447
oai_identifier_str oai:repositorio.chporto.pt:10400.16/2905
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Timely and Blood-Based Multiplex Molecular Profiling of Acute StrokePOC devicesbiomarkersbiosensorsbloodstrokeStroke is a leading cause of death and disability in the world. To address such a problem, early diagnosis and tailored acute treatment represent one of the major priorities in acute stroke care. Since the efficacy of reperfusion treatments is highly time-dependent, there is a critical need to optimize procedures for faster and more precise diagnosis. We provide a concise review of the most relevant and well-documented blood-protein biomarkers that exhibit greater potential for translational to clinical practice in stroke differential diagnosis and to differentiate ischemic stroke from hemorrhagic stroke, followed by an overview of the most recent point-of-care technological approaches to address this problem. The integration of fluid-based biomarker profiling, using point-of-care biosensors with demographic, clinical, and neuroimaging parameters in multi-dimensional clinical decision-making algorithms, will be the next step in personalized stroke care.MDPIRepositório Científico do Centro Hospitalar Universitário de Santo AntónioDias, AlexandreSilva, IsabelPinto, Inês MendesMaia, Luis2024-01-30T12:17:57Z2021-082021-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2905engDias A, Silva I, Pinto IM, Maia LF. Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke. Life (Basel). 2021;11(8):816. doi:10.3390/life110808162075-172910.3390/life11080816info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-01T07:18:14Zoai:repositorio.chporto.pt:10400.16/2905Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:59:22.470340Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke
title Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke
spellingShingle Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke
Dias, Alexandre
POC devices
biomarkers
biosensors
blood
stroke
title_short Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke
title_full Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke
title_fullStr Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke
title_full_unstemmed Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke
title_sort Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke
author Dias, Alexandre
author_facet Dias, Alexandre
Silva, Isabel
Pinto, Inês Mendes
Maia, Luis
author_role author
author2 Silva, Isabel
Pinto, Inês Mendes
Maia, Luis
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Centro Hospitalar Universitário de Santo António
dc.contributor.author.fl_str_mv Dias, Alexandre
Silva, Isabel
Pinto, Inês Mendes
Maia, Luis
dc.subject.por.fl_str_mv POC devices
biomarkers
biosensors
blood
stroke
topic POC devices
biomarkers
biosensors
blood
stroke
description Stroke is a leading cause of death and disability in the world. To address such a problem, early diagnosis and tailored acute treatment represent one of the major priorities in acute stroke care. Since the efficacy of reperfusion treatments is highly time-dependent, there is a critical need to optimize procedures for faster and more precise diagnosis. We provide a concise review of the most relevant and well-documented blood-protein biomarkers that exhibit greater potential for translational to clinical practice in stroke differential diagnosis and to differentiate ischemic stroke from hemorrhagic stroke, followed by an overview of the most recent point-of-care technological approaches to address this problem. The integration of fluid-based biomarker profiling, using point-of-care biosensors with demographic, clinical, and neuroimaging parameters in multi-dimensional clinical decision-making algorithms, will be the next step in personalized stroke care.
publishDate 2021
dc.date.none.fl_str_mv 2021-08
2021-08-01T00:00:00Z
2024-01-30T12:17:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.16/2905
url http://hdl.handle.net/10400.16/2905
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dias A, Silva I, Pinto IM, Maia LF. Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke. Life (Basel). 2021;11(8):816. doi:10.3390/life11080816
2075-1729
10.3390/life11080816
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137077607006208

Registros relacionados