Time since onset might be of essence: a recommendation to assess the effects of combination of non-pharmacological neuromodulatory approaches at early stage since symptoms onset
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/40380 |
Resumo: | In the past decade researchers began to assess the potential beneficial effects of non-invasive brain stimulation (NIBS) combined with a behavioral task as a treatment approach for various medical conditions. Transcranial direct current stimulation (tDCS) applied to the motor cortex combined with another treatment approach has been assessed as analgesic treatment in neuropathic and non-neuropathic pain conditions, and was found to exert only modest pain relief. Our group results show that combined tDCS and mirror therapy dramatically reduced acute phantom limb pain intensity with long-lasting effects, potentially preventing pain chronification. A review of the scientific literature indicates that our approach differs from that of others: We applied the intervention at the acute stage of the disease, whereas other studies applied the intervention in patients whose disease had already been established. We suggest that the timing of administration of the combined intervention is critical. Unlike in patients with chronic painful condition, in which the maladaptive plasticity associated with pain chronification and chronicity is well-consolidated, early treatment at the acute pain stage may be more successful in counterbalancing the not-yet consolidated maladaptive plasticity. We encourage the research community to test our hypothesis, both in the treatment of pain, and beyond. |
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Time since onset might be of essence: a recommendation to assess the effects of combination of non-pharmacological neuromodulatory approaches at early stage since symptoms onsetAnalgesic therapyCombined therapyMirror therapyNeuromodulationNon-invasive brain stimulationIn the past decade researchers began to assess the potential beneficial effects of non-invasive brain stimulation (NIBS) combined with a behavioral task as a treatment approach for various medical conditions. Transcranial direct current stimulation (tDCS) applied to the motor cortex combined with another treatment approach has been assessed as analgesic treatment in neuropathic and non-neuropathic pain conditions, and was found to exert only modest pain relief. Our group results show that combined tDCS and mirror therapy dramatically reduced acute phantom limb pain intensity with long-lasting effects, potentially preventing pain chronification. A review of the scientific literature indicates that our approach differs from that of others: We applied the intervention at the acute stage of the disease, whereas other studies applied the intervention in patients whose disease had already been established. We suggest that the timing of administration of the combined intervention is critical. Unlike in patients with chronic painful condition, in which the maladaptive plasticity associated with pain chronification and chronicity is well-consolidated, early treatment at the acute pain stage may be more successful in counterbalancing the not-yet consolidated maladaptive plasticity. We encourage the research community to test our hypothesis, both in the treatment of pain, and beyond.Veritati - Repositório Institucional da Universidade Católica PortuguesaAgostinho, MarianaWeissman Fogel, IritTreister, Roi2023-03-01T09:01:24Z2023-02-082023-02-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/40380eng1664-229510.3389/fneur.2023.111537085147991897PMC992317436793488000931117900001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:45:54Zoai:repositorio.ucp.pt:10400.14/40380Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:33:07.588875Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Time since onset might be of essence: a recommendation to assess the effects of combination of non-pharmacological neuromodulatory approaches at early stage since symptoms onset |
title |
Time since onset might be of essence: a recommendation to assess the effects of combination of non-pharmacological neuromodulatory approaches at early stage since symptoms onset |
spellingShingle |
Time since onset might be of essence: a recommendation to assess the effects of combination of non-pharmacological neuromodulatory approaches at early stage since symptoms onset Agostinho, Mariana Analgesic therapy Combined therapy Mirror therapy Neuromodulation Non-invasive brain stimulation |
title_short |
Time since onset might be of essence: a recommendation to assess the effects of combination of non-pharmacological neuromodulatory approaches at early stage since symptoms onset |
title_full |
Time since onset might be of essence: a recommendation to assess the effects of combination of non-pharmacological neuromodulatory approaches at early stage since symptoms onset |
title_fullStr |
Time since onset might be of essence: a recommendation to assess the effects of combination of non-pharmacological neuromodulatory approaches at early stage since symptoms onset |
title_full_unstemmed |
Time since onset might be of essence: a recommendation to assess the effects of combination of non-pharmacological neuromodulatory approaches at early stage since symptoms onset |
title_sort |
Time since onset might be of essence: a recommendation to assess the effects of combination of non-pharmacological neuromodulatory approaches at early stage since symptoms onset |
author |
Agostinho, Mariana |
author_facet |
Agostinho, Mariana Weissman Fogel, Irit Treister, Roi |
author_role |
author |
author2 |
Weissman Fogel, Irit Treister, Roi |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Agostinho, Mariana Weissman Fogel, Irit Treister, Roi |
dc.subject.por.fl_str_mv |
Analgesic therapy Combined therapy Mirror therapy Neuromodulation Non-invasive brain stimulation |
topic |
Analgesic therapy Combined therapy Mirror therapy Neuromodulation Non-invasive brain stimulation |
description |
In the past decade researchers began to assess the potential beneficial effects of non-invasive brain stimulation (NIBS) combined with a behavioral task as a treatment approach for various medical conditions. Transcranial direct current stimulation (tDCS) applied to the motor cortex combined with another treatment approach has been assessed as analgesic treatment in neuropathic and non-neuropathic pain conditions, and was found to exert only modest pain relief. Our group results show that combined tDCS and mirror therapy dramatically reduced acute phantom limb pain intensity with long-lasting effects, potentially preventing pain chronification. A review of the scientific literature indicates that our approach differs from that of others: We applied the intervention at the acute stage of the disease, whereas other studies applied the intervention in patients whose disease had already been established. We suggest that the timing of administration of the combined intervention is critical. Unlike in patients with chronic painful condition, in which the maladaptive plasticity associated with pain chronification and chronicity is well-consolidated, early treatment at the acute pain stage may be more successful in counterbalancing the not-yet consolidated maladaptive plasticity. We encourage the research community to test our hypothesis, both in the treatment of pain, and beyond. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-01T09:01:24Z 2023-02-08 2023-02-08T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/40380 |
url |
http://hdl.handle.net/10400.14/40380 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1664-2295 10.3389/fneur.2023.1115370 85147991897 PMC9923174 36793488 000931117900001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132057136267264 |