Emergence of drug-resistance in HIV dynamics under distinct HAARTregimes

• Autor(a) principal: Pinto, Carla M.A.
• Data de Publicação: 2016
• Outros Autores: Carvalho, Ana R.M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.22/9148
• topic: HAART regimes; Drug-resistance; Rapid progressors; Long-term-non-progressors

In this paper we propose a model for the dynamics of HIV epidemics under distinct HAART regimes, and study the emergence of drug-resistance. The model predicts HIV dynamics of untreated HIV patients for all stages of the infection. We compute the local and the global stability of the disease-free equilibrium of the model. We simulate the model for two distinct HIV patients, the rapid progressors and the long-term non-progressors. We study the effects of equal RTI and PI efficacies, as well as distinct drug efficacies, namely RTI-based and PI-based therapeutics. Treatment is initiated when the CD4+ T cells count is less than 350 cells mm−3. The PI-based drugs seem to produce better outcomes, with respect to disease progression, than RTI-based regimes.