Does repetitive transcranial magnetic stimulation have positive effects on adults with eating disorders and/or excessive weight?
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/8711 |
Resumo: | Background Eating disorders (ED) are chronic illnesses with treatments of limited proven efficacy. Re-petitive transcranial magnetic stimulation (rTMS) has been investigated as a therapeutic tool for neuropsychiatric illnesses and is already certified for major depression disorder (MDD). There is evidence that when the left dorsolateral pre-frontal cortex (dlPFC) is targeted, the ED sympto-matology is improved. Objectives This article is a systematic review that intends to assess the validity of rTMS as a therapy for ED and food craving. Methods We conducted a literature search using the following search terms: rTMS, ED, anorexia, bulimia, binge-eating disorder and excessive weight. Articles published in English and indexed in the following databases were searched: Pubmed, Embase, hinari; inasp; eIFL; Cochrane Library; EBSCO; CINAHL; Current Contents; DARE; metacrawler; PsycINFO. Results All studies (5 in total) assessed the effects of rTMS on dlPFC. Van den Eynde et al. (1), showed that the real rTMS group with BN (n=17) had a significant reduction in cue-induced food craving (p=0.028). Walpoth and colleagues (2) studied 14 women with BN in whom the average number of binges per day did not declined significantly in the active group (n=7) relatively to placebo (p=0,211). Gay et al. (3) concluded that there were no significant improvements in binge-ing/purging symptoms in BN patients (p=0.96). Kim et al. (4) examined the effects of four rTMS sessions (n=57) in overweight patients, showing a significant weight loss in the intervention group (p=0.002). McClelland et al. (5) studied the effects of one session of rTMS and concluded that there was no significant reduction of core anorexia symptoms (p>0.05). Given the heterogeneity of par-ticipants/pathologies and results it was not possible to perform a meta-analysis. Conclusions Excitatory rTMS appears to have a positive effect in changing ED sympotms. More studies, especially RCT with large samples, are needed. |
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Does repetitive transcranial magnetic stimulation have positive effects on adults with eating disorders and/or excessive weight?Cortex Pré-FrontalEstimulação Magnética TranscranianaExcesso de PesoNeuromodulaçãoPerturbações AlimentaresRevisão SistemáticaDomínio/Área Científica::Ciências Médicas::Ciências da Saúde::MedicinaBackground Eating disorders (ED) are chronic illnesses with treatments of limited proven efficacy. Re-petitive transcranial magnetic stimulation (rTMS) has been investigated as a therapeutic tool for neuropsychiatric illnesses and is already certified for major depression disorder (MDD). There is evidence that when the left dorsolateral pre-frontal cortex (dlPFC) is targeted, the ED sympto-matology is improved. Objectives This article is a systematic review that intends to assess the validity of rTMS as a therapy for ED and food craving. Methods We conducted a literature search using the following search terms: rTMS, ED, anorexia, bulimia, binge-eating disorder and excessive weight. Articles published in English and indexed in the following databases were searched: Pubmed, Embase, hinari; inasp; eIFL; Cochrane Library; EBSCO; CINAHL; Current Contents; DARE; metacrawler; PsycINFO. Results All studies (5 in total) assessed the effects of rTMS on dlPFC. Van den Eynde et al. (1), showed that the real rTMS group with BN (n=17) had a significant reduction in cue-induced food craving (p=0.028). Walpoth and colleagues (2) studied 14 women with BN in whom the average number of binges per day did not declined significantly in the active group (n=7) relatively to placebo (p=0,211). Gay et al. (3) concluded that there were no significant improvements in binge-ing/purging symptoms in BN patients (p=0.96). Kim et al. (4) examined the effects of four rTMS sessions (n=57) in overweight patients, showing a significant weight loss in the intervention group (p=0.002). McClelland et al. (5) studied the effects of one session of rTMS and concluded that there was no significant reduction of core anorexia symptoms (p>0.05). Given the heterogeneity of par-ticipants/pathologies and results it was not possible to perform a meta-analysis. Conclusions Excitatory rTMS appears to have a positive effect in changing ED sympotms. More studies, especially RCT with large samples, are needed.Background Perturbações alimentares (PA) são patologias com tratamentos de eficácia limitada. A es-timulação magnética transcraniana repetitiva (rTMS) tem sido estudada como terapia para pato-logias neuropsiquiátricas como a perturbação depressiva major (PDM). Há evidências sobre a sua eficácia na melhoria da sintomatologia das PA quando aplicada ao córtex pré-frontal dorsolateral (dlPFC) esquerdo. Objetivos Esta tese é uma revisão sistemática sobre o uso de rTMS como terapia para bulimia, ano-rexia e perturbação de binge eating, bem como o desejo por comida em indivíduos com excesso de peso. Materiais e métodos Realizou-se uma revisão sistemática de ensaios clínicos randomizados (ECR) com base na pesquisa bibliográfica eletrónica utilizando os termos: rTMS, bulimia, anorexia, binge-eating e overweight. Os critérios de inclusão foram: ECR em inglês, qualquer sexo ou étnia, 18 anos ou mais, IMC superior a 25 kg/??2, diagnostico de PA; uso de rTMS. Resultados Os estudos incluídos (5 no total) incidem sobre o efeito da rTMS no dlPFC esquerdo. Van den Eynde et al. (1) mostraram que o grupo de BN tratado por rTMS (n=17) teve uma redução significativa nas compulsões alimentares (p=0,028). Walpoth et al. (2) estudaram 14 mulheres com BN nas quais o número médio de compulsões alimentares por dia não diminuiu no grupo de inter-venção (n=7) relativamente ao de placebo (p=0,211). Gay et al. (3) investigaram 47 mulheres com BN e concluíram que não houve melhoria significativa nos sintomas de compulsão alimentar (p=0,96). Kim et al. (4) examinaram os efeitos de 4 sessões de rTMS (n=57), em doentes com excesso de peso tendo o grupo estimulado apresentado perda de peso significativa (p=0,002). McClelland et al. (5) estudaram os efeitos de uma sessão de rTMS em 49 pacientes com AN, con-cluindo que não houve efeitos significativos na redução dos sintomas nucleares de AN (p>0.05). Dada a heterogeneidade dos participantes/patologias e resultados, não foi possível realizar uma meta-análise. Conclusão A estimulação no dlPFC esquerdo por rTMS parece ter um papel positivo na modulação dos sintomas das perturbações alimentares. Mais estudos, especialmente com ECR e com amostras maiores são necessários.Patto, Maria da Assunção Morais e Cunha VazPinto, Nuno Filipe CardosouBibliorumBatista, Pedro Garcia2020-01-23T17:11:58Z2019-06-142019-05-082019-06-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.6/8711TID:202374220enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:48:59Zoai:ubibliorum.ubi.pt:10400.6/8711Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:48:59.469968Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Does repetitive transcranial magnetic stimulation have positive effects on adults with eating disorders and/or excessive weight? |
title |
Does repetitive transcranial magnetic stimulation have positive effects on adults with eating disorders and/or excessive weight? |
spellingShingle |
Does repetitive transcranial magnetic stimulation have positive effects on adults with eating disorders and/or excessive weight? Batista, Pedro Garcia Cortex Pré-Frontal Estimulação Magnética Transcraniana Excesso de Peso Neuromodulação Perturbações Alimentares Revisão Sistemática Domínio/Área Científica::Ciências Médicas::Ciências da Saúde::Medicina |
title_short |
Does repetitive transcranial magnetic stimulation have positive effects on adults with eating disorders and/or excessive weight? |
title_full |
Does repetitive transcranial magnetic stimulation have positive effects on adults with eating disorders and/or excessive weight? |
title_fullStr |
Does repetitive transcranial magnetic stimulation have positive effects on adults with eating disorders and/or excessive weight? |
title_full_unstemmed |
Does repetitive transcranial magnetic stimulation have positive effects on adults with eating disorders and/or excessive weight? |
title_sort |
Does repetitive transcranial magnetic stimulation have positive effects on adults with eating disorders and/or excessive weight? |
author |
Batista, Pedro Garcia |
author_facet |
Batista, Pedro Garcia |
author_role |
author |
dc.contributor.none.fl_str_mv |
Patto, Maria da Assunção Morais e Cunha Vaz Pinto, Nuno Filipe Cardoso uBibliorum |
dc.contributor.author.fl_str_mv |
Batista, Pedro Garcia |
dc.subject.por.fl_str_mv |
Cortex Pré-Frontal Estimulação Magnética Transcraniana Excesso de Peso Neuromodulação Perturbações Alimentares Revisão Sistemática Domínio/Área Científica::Ciências Médicas::Ciências da Saúde::Medicina |
topic |
Cortex Pré-Frontal Estimulação Magnética Transcraniana Excesso de Peso Neuromodulação Perturbações Alimentares Revisão Sistemática Domínio/Área Científica::Ciências Médicas::Ciências da Saúde::Medicina |
description |
Background Eating disorders (ED) are chronic illnesses with treatments of limited proven efficacy. Re-petitive transcranial magnetic stimulation (rTMS) has been investigated as a therapeutic tool for neuropsychiatric illnesses and is already certified for major depression disorder (MDD). There is evidence that when the left dorsolateral pre-frontal cortex (dlPFC) is targeted, the ED sympto-matology is improved. Objectives This article is a systematic review that intends to assess the validity of rTMS as a therapy for ED and food craving. Methods We conducted a literature search using the following search terms: rTMS, ED, anorexia, bulimia, binge-eating disorder and excessive weight. Articles published in English and indexed in the following databases were searched: Pubmed, Embase, hinari; inasp; eIFL; Cochrane Library; EBSCO; CINAHL; Current Contents; DARE; metacrawler; PsycINFO. Results All studies (5 in total) assessed the effects of rTMS on dlPFC. Van den Eynde et al. (1), showed that the real rTMS group with BN (n=17) had a significant reduction in cue-induced food craving (p=0.028). Walpoth and colleagues (2) studied 14 women with BN in whom the average number of binges per day did not declined significantly in the active group (n=7) relatively to placebo (p=0,211). Gay et al. (3) concluded that there were no significant improvements in binge-ing/purging symptoms in BN patients (p=0.96). Kim et al. (4) examined the effects of four rTMS sessions (n=57) in overweight patients, showing a significant weight loss in the intervention group (p=0.002). McClelland et al. (5) studied the effects of one session of rTMS and concluded that there was no significant reduction of core anorexia symptoms (p>0.05). Given the heterogeneity of par-ticipants/pathologies and results it was not possible to perform a meta-analysis. Conclusions Excitatory rTMS appears to have a positive effect in changing ED sympotms. More studies, especially RCT with large samples, are needed. |
publishDate |
2019 |
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2019-06-14 2019-05-08 2019-06-14T00:00:00Z 2020-01-23T17:11:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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