Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases

Bibliographic Details
Main Author: Salehi, B
Publication Date: 2020
Other Authors: Del Prado-Audelo, ML, Cortés, H, Leyva-gómez, G, Stojanovic-radic, Z, Singh, YD, Patra, JK, Das, G, Martins, N, Martorell, M, Sharifi-rad, M, Cho, WC, Sharifi-rad, J
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: https://hdl.handle.net/10216/145263
Summary: Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.
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spelling Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseasesCardiovascular diseaseCurcuminLiposomeNanocurcuminNanoformulationNanomedicineCardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.MDPI20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/145263eng2077-038310.3390/jcm9030746Salehi, BDel Prado-Audelo, MLCortés, HLeyva-gómez, GStojanovic-radic, ZSingh, YDPatra, JKDas, GMartins, NMartorell, MSharifi-rad, MCho, WCSharifi-rad, Jinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:37:32Zoai:repositorio-aberto.up.pt:10216/145263Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:44:10.432911Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases
title Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases
spellingShingle Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases
Salehi, B
Cardiovascular disease
Curcumin
Liposome
Nanocurcumin
Nanoformulation
Nanomedicine
title_short Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases
title_full Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases
title_fullStr Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases
title_full_unstemmed Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases
title_sort Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases
author Salehi, B
author_facet Salehi, B
Del Prado-Audelo, ML
Cortés, H
Leyva-gómez, G
Stojanovic-radic, Z
Singh, YD
Patra, JK
Das, G
Martins, N
Martorell, M
Sharifi-rad, M
Cho, WC
Sharifi-rad, J
author_role author
author2 Del Prado-Audelo, ML
Cortés, H
Leyva-gómez, G
Stojanovic-radic, Z
Singh, YD
Patra, JK
Das, G
Martins, N
Martorell, M
Sharifi-rad, M
Cho, WC
Sharifi-rad, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Salehi, B
Del Prado-Audelo, ML
Cortés, H
Leyva-gómez, G
Stojanovic-radic, Z
Singh, YD
Patra, JK
Das, G
Martins, N
Martorell, M
Sharifi-rad, M
Cho, WC
Sharifi-rad, J
dc.subject.por.fl_str_mv Cardiovascular disease
Curcumin
Liposome
Nanocurcumin
Nanoformulation
Nanomedicine
topic Cardiovascular disease
Curcumin
Liposome
Nanocurcumin
Nanoformulation
Nanomedicine
description Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
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dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/145263
url https://hdl.handle.net/10216/145263
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2077-0383
10.3390/jcm9030746
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
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instacron:RCAAP
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instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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