Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases
Main Author: | |
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Publication Date: | 2020 |
Other Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | https://hdl.handle.net/10216/145263 |
Summary: | Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems. |
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Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseasesCardiovascular diseaseCurcuminLiposomeNanocurcuminNanoformulationNanomedicineCardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.MDPI20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/145263eng2077-038310.3390/jcm9030746Salehi, BDel Prado-Audelo, MLCortés, HLeyva-gómez, GStojanovic-radic, ZSingh, YDPatra, JKDas, GMartins, NMartorell, MSharifi-rad, MCho, WCSharifi-rad, Jinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:37:32Zoai:repositorio-aberto.up.pt:10216/145263Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:44:10.432911Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases |
title |
Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases |
spellingShingle |
Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases Salehi, B Cardiovascular disease Curcumin Liposome Nanocurcumin Nanoformulation Nanomedicine |
title_short |
Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases |
title_full |
Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases |
title_fullStr |
Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases |
title_full_unstemmed |
Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases |
title_sort |
Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases |
author |
Salehi, B |
author_facet |
Salehi, B Del Prado-Audelo, ML Cortés, H Leyva-gómez, G Stojanovic-radic, Z Singh, YD Patra, JK Das, G Martins, N Martorell, M Sharifi-rad, M Cho, WC Sharifi-rad, J |
author_role |
author |
author2 |
Del Prado-Audelo, ML Cortés, H Leyva-gómez, G Stojanovic-radic, Z Singh, YD Patra, JK Das, G Martins, N Martorell, M Sharifi-rad, M Cho, WC Sharifi-rad, J |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Salehi, B Del Prado-Audelo, ML Cortés, H Leyva-gómez, G Stojanovic-radic, Z Singh, YD Patra, JK Das, G Martins, N Martorell, M Sharifi-rad, M Cho, WC Sharifi-rad, J |
dc.subject.por.fl_str_mv |
Cardiovascular disease Curcumin Liposome Nanocurcumin Nanoformulation Nanomedicine |
topic |
Cardiovascular disease Curcumin Liposome Nanocurcumin Nanoformulation Nanomedicine |
description |
Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/145263 |
url |
https://hdl.handle.net/10216/145263 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2077-0383 10.3390/jcm9030746 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135757058703360 |