Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2741 |
Resumo: | Background: Early life exposures impact immune system development and therefore the risk of immune-mediated diseases, including inflammatory bowel disease (IBD). We systematically reviewed the impact of pre-, peri‑, and postnatal exposures up to the age of five years on subsequent IBD diagnosis. Methods: We identified case-control and cohort studies reporting on the association between early life environmental factors and Crohn's disease (CD), ulcerative colitis (UC), or IBD overall. Databases were search from their inception until May 24th, 2019 until July 14th, 2020. We conducted meta-analyses for quantitative review of relevant risk factors that were comparable across studies and qualitative synthesis of the literature for a wide range of early life exposures, including maternal health and exposures during pregnancy, perinatal factors, birth month and related-factors, breastfeeding, hygiene-related factors and social factors, immigration, antibiotics, offspring health, including infections, and passive smoking. PROSPERO registration: CRD42019134980. Findings: Prenatal exposure to antibiotics (OR 1.8; 95% CI 1.2-2.5) and tobacco smoke (OR 1.5; 95% CI 1.2-1.9), and early life otitis media (OR 2.1; 95% CI 1.2-3.6) were associated with IBD. There was a trend towards an association between exposure to antibiotics in infancy and IBD (OR: 1.7, 95% CI 0.97, 2.9), supported by positive data on population-based data. Breastfeeding was protective against IBD. Other early life risk factors had no association with IBD, but data were limited and heterogenous. Interpretation: Early life is an important period of susceptibility for IBD development later in life. Tobacco smoke, infections and antibiotics were associated positively, and breastfeeding was associated negatively with IBD. Our findings offer an opportunity to develop primary prevention strategies. |
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Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analysesCrohn's diseaseEarly lifeEnvironmental exposureEpidemiologyInflammatory bowel diseaseNon-geneticRisk factorsUlcerative colitisBackground: Early life exposures impact immune system development and therefore the risk of immune-mediated diseases, including inflammatory bowel disease (IBD). We systematically reviewed the impact of pre-, peri‑, and postnatal exposures up to the age of five years on subsequent IBD diagnosis. Methods: We identified case-control and cohort studies reporting on the association between early life environmental factors and Crohn's disease (CD), ulcerative colitis (UC), or IBD overall. Databases were search from their inception until May 24th, 2019 until July 14th, 2020. We conducted meta-analyses for quantitative review of relevant risk factors that were comparable across studies and qualitative synthesis of the literature for a wide range of early life exposures, including maternal health and exposures during pregnancy, perinatal factors, birth month and related-factors, breastfeeding, hygiene-related factors and social factors, immigration, antibiotics, offspring health, including infections, and passive smoking. PROSPERO registration: CRD42019134980. Findings: Prenatal exposure to antibiotics (OR 1.8; 95% CI 1.2-2.5) and tobacco smoke (OR 1.5; 95% CI 1.2-1.9), and early life otitis media (OR 2.1; 95% CI 1.2-3.6) were associated with IBD. There was a trend towards an association between exposure to antibiotics in infancy and IBD (OR: 1.7, 95% CI 0.97, 2.9), supported by positive data on population-based data. Breastfeeding was protective against IBD. Other early life risk factors had no association with IBD, but data were limited and heterogenous. Interpretation: Early life is an important period of susceptibility for IBD development later in life. Tobacco smoke, infections and antibiotics were associated positively, and breastfeeding was associated negatively with IBD. Our findings offer an opportunity to develop primary prevention strategies.The LancetRepositório Científico do Centro Hospitalar Universitário de Santo AntónioAgrawal, ManasiSabino, JoãoFrias-Gomes, CatarinaHillenbrand, Christen M.Soudant, CelineAxelrad, Jordan E.Shah, Shailja C.Ribeiro-Mourão, FranciscoLambin, ThomasPeter, IngaColombel, Jean-FredericNarula, NeerajTorres, Joana2022-11-10T10:10:01Z2021-05-152021-05-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2741engAgrawal M, Sabino J, Frias-Gomes C, et al. Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses. EClinicalMedicine. 2021;36:100884. doi:10.1016/j.eclinm.2021.1008842589-537010.1016/j.eclinm.2021.100884info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:02:08Zoai:repositorio.chporto.pt:10400.16/2741Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:55.805339Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses |
title |
Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses |
spellingShingle |
Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses Agrawal, Manasi Crohn's disease Early life Environmental exposure Epidemiology Inflammatory bowel disease Non-genetic Risk factors Ulcerative colitis |
title_short |
Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses |
title_full |
Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses |
title_fullStr |
Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses |
title_full_unstemmed |
Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses |
title_sort |
Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses |
author |
Agrawal, Manasi |
author_facet |
Agrawal, Manasi Sabino, João Frias-Gomes, Catarina Hillenbrand, Christen M. Soudant, Celine Axelrad, Jordan E. Shah, Shailja C. Ribeiro-Mourão, Francisco Lambin, Thomas Peter, Inga Colombel, Jean-Frederic Narula, Neeraj Torres, Joana |
author_role |
author |
author2 |
Sabino, João Frias-Gomes, Catarina Hillenbrand, Christen M. Soudant, Celine Axelrad, Jordan E. Shah, Shailja C. Ribeiro-Mourão, Francisco Lambin, Thomas Peter, Inga Colombel, Jean-Frederic Narula, Neeraj Torres, Joana |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Agrawal, Manasi Sabino, João Frias-Gomes, Catarina Hillenbrand, Christen M. Soudant, Celine Axelrad, Jordan E. Shah, Shailja C. Ribeiro-Mourão, Francisco Lambin, Thomas Peter, Inga Colombel, Jean-Frederic Narula, Neeraj Torres, Joana |
dc.subject.por.fl_str_mv |
Crohn's disease Early life Environmental exposure Epidemiology Inflammatory bowel disease Non-genetic Risk factors Ulcerative colitis |
topic |
Crohn's disease Early life Environmental exposure Epidemiology Inflammatory bowel disease Non-genetic Risk factors Ulcerative colitis |
description |
Background: Early life exposures impact immune system development and therefore the risk of immune-mediated diseases, including inflammatory bowel disease (IBD). We systematically reviewed the impact of pre-, peri‑, and postnatal exposures up to the age of five years on subsequent IBD diagnosis. Methods: We identified case-control and cohort studies reporting on the association between early life environmental factors and Crohn's disease (CD), ulcerative colitis (UC), or IBD overall. Databases were search from their inception until May 24th, 2019 until July 14th, 2020. We conducted meta-analyses for quantitative review of relevant risk factors that were comparable across studies and qualitative synthesis of the literature for a wide range of early life exposures, including maternal health and exposures during pregnancy, perinatal factors, birth month and related-factors, breastfeeding, hygiene-related factors and social factors, immigration, antibiotics, offspring health, including infections, and passive smoking. PROSPERO registration: CRD42019134980. Findings: Prenatal exposure to antibiotics (OR 1.8; 95% CI 1.2-2.5) and tobacco smoke (OR 1.5; 95% CI 1.2-1.9), and early life otitis media (OR 2.1; 95% CI 1.2-3.6) were associated with IBD. There was a trend towards an association between exposure to antibiotics in infancy and IBD (OR: 1.7, 95% CI 0.97, 2.9), supported by positive data on population-based data. Breastfeeding was protective against IBD. Other early life risk factors had no association with IBD, but data were limited and heterogenous. Interpretation: Early life is an important period of susceptibility for IBD development later in life. Tobacco smoke, infections and antibiotics were associated positively, and breastfeeding was associated negatively with IBD. Our findings offer an opportunity to develop primary prevention strategies. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-15 2021-05-15T00:00:00Z 2022-11-10T10:10:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2741 |
url |
http://hdl.handle.net/10400.16/2741 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Agrawal M, Sabino J, Frias-Gomes C, et al. Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses. EClinicalMedicine. 2021;36:100884. doi:10.1016/j.eclinm.2021.100884 2589-5370 10.1016/j.eclinm.2021.100884 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
The Lancet |
publisher.none.fl_str_mv |
The Lancet |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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