Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application

Detalhes bibliográficos
Autor(a) principal: Carriço, Catarina
Data de Publicação: 2019
Outros Autores: Pinto, Pedro, Graça, Angélica, Gonçalves, Lídia, Ribeiro, Helena, Marto, Joana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/61996
Resumo: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical ApplicationQuercus suber L.Quercus Suber Bark particlesPickering emulsionanti-oxidant activityQuality by Design approach© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Quercus Suber Bark from Quercus suber L. is a natural, renewable and biodegradable biomaterial with multifunctional proprieties. In this study, we used it as solid particles to stabilize a Pickering emulsion. The main goal was to produce an optimized topical formulation using biocompatible organic particles as stabilizers of the emulsion instead of the common surfactants, whilst benefiting from Quercus suber L. proprieties. In this work, a Quality by Design (QbD) approach was successfully applied to the production of this emulsion. A screening design was conducted, identifying the critical variables of the formula and process, affecting the critical quality attributes of the emulsion (droplet size distribution). The optimization of the production was made through the establishment of the design space. The stability was also investigated during 30 days, demonstrating that Quercus Suber Bark-stabilized emulsions are stable since the droplet size distribution lowers. In vitro studies were performed to assess antioxidant and antiaging efficacy, which revealed that the formulation had indeed antioxidant proprieties. A physicochemical characterization demonstrated that the formulation presents a shear-thinning fluid, ideal for topical administration. The in vivo compatibility study confirmed that the final formulation is not skin irritant, being safe for human use. A sensorial analysis was also performed, using a simple sensory questionnaire, revealing very positive results. Thus, the use of Quercus Suber Bark particles as a multifunctional solid ingredient contributed to achieve a stable, effective and innovative Pickering emulsion with a meaningful synergistic protection against oxidative stress.This research was funded by Fundação para a Ciência e a Tecnologia, Portugal (UID/DTP/04138/2013 and PTDC/MEC-DER/30198/2017).MDPIRepositório da Universidade de LisboaCarriço, CatarinaPinto, PedroGraça, AngélicaGonçalves, LídiaRibeiro, HelenaMarto, Joana2024-01-19T18:44:56Z2019-032023-02-27T18:48:28Z2019-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/61996engCarriço C, Pinto P, Graça A, Gonçalves L, Ribeiro H, Marto J. Design and characterization of a new quercus suber-based pickering emulsion for topical application. Pharmaceutics [Internet]. 19 de março de 2019;11(3):131. Disponível em: https://www.mdpi.com/1999-4923/11/3/131cv-prod-53503610.3390/pharmaceutics110301312-s2.0-85068356545info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:19:46Zoai:repositorio.ul.pt:10451/61996Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:19:46Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application
title Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application
spellingShingle Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application
Carriço, Catarina
Quercus suber L.
Quercus Suber Bark particles
Pickering emulsion
anti-oxidant activity
Quality by Design approach
title_short Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application
title_full Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application
title_fullStr Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application
title_full_unstemmed Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application
title_sort Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application
author Carriço, Catarina
author_facet Carriço, Catarina
Pinto, Pedro
Graça, Angélica
Gonçalves, Lídia
Ribeiro, Helena
Marto, Joana
author_role author
author2 Pinto, Pedro
Graça, Angélica
Gonçalves, Lídia
Ribeiro, Helena
Marto, Joana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Carriço, Catarina
Pinto, Pedro
Graça, Angélica
Gonçalves, Lídia
Ribeiro, Helena
Marto, Joana
dc.subject.por.fl_str_mv Quercus suber L.
Quercus Suber Bark particles
Pickering emulsion
anti-oxidant activity
Quality by Design approach
topic Quercus suber L.
Quercus Suber Bark particles
Pickering emulsion
anti-oxidant activity
Quality by Design approach
description © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2019
dc.date.none.fl_str_mv 2019-03
2019-03-01T00:00:00Z
2023-02-27T18:48:28Z
2024-01-19T18:44:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/61996
url http://hdl.handle.net/10451/61996
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carriço C, Pinto P, Graça A, Gonçalves L, Ribeiro H, Marto J. Design and characterization of a new quercus suber-based pickering emulsion for topical application. Pharmaceutics [Internet]. 19 de março de 2019;11(3):131. Disponível em: https://www.mdpi.com/1999-4923/11/3/131
cv-prod-535036
10.3390/pharmaceutics11030131
2-s2.0-85068356545
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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