Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/4151 |
Resumo: | Tributyltin chloride is still a relevant water and seafood pollutant, as reported for some sites of Mediterranean and Iberian coastal waters. We evaluated TBT metabolic effect in Wistar male rats, after administration of a repeated oral dose of 8.5mg/L in ethanol 0.25%, during 28 days, according to DIR96/54/EC. Groups of six animals, individually caged, were daily observed for fast blood glycaemia and semi-quantitative urine analysis. Glycaemic levels were significantly lower on the test group along the assay, showing a tendency for fasting hypoglycaemia. Urine analysis showed the presence of ketonic bodies in test group during the treatment. At the end of test period, animals were euthanized and serum analysis was performed revealing a significant increment of cholesterol and HDL-cholesterol (9.3% and 6.7%, respectively) and a non-significant increment on triglycerides content. These results suggest that TBT disrupted glucose and lipid homeostasis. Accordingly, and considering TBT a new member of environmental obesogen family, it is most relevant to reassess the effect of chronic exposure to low doses of this pollutant. |
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Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male ratsTributyltinRatglycaemiaTributyltin chloride is still a relevant water and seafood pollutant, as reported for some sites of Mediterranean and Iberian coastal waters. We evaluated TBT metabolic effect in Wistar male rats, after administration of a repeated oral dose of 8.5mg/L in ethanol 0.25%, during 28 days, according to DIR96/54/EC. Groups of six animals, individually caged, were daily observed for fast blood glycaemia and semi-quantitative urine analysis. Glycaemic levels were significantly lower on the test group along the assay, showing a tendency for fasting hypoglycaemia. Urine analysis showed the presence of ketonic bodies in test group during the treatment. At the end of test period, animals were euthanized and serum analysis was performed revealing a significant increment of cholesterol and HDL-cholesterol (9.3% and 6.7%, respectively) and a non-significant increment on triglycerides content. These results suggest that TBT disrupted glucose and lipid homeostasis. Accordingly, and considering TBT a new member of environmental obesogen family, it is most relevant to reassess the effect of chronic exposure to low doses of this pollutant.SETAC Europe 18th Annual Meeting2012-01-25T12:51:37Z2012-01-252008-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjecthttp://hdl.handle.net/10174/4151http://hdl.handle.net/10174/4151engTributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats. Ana C.R. Costa, Sandra M. Branco, Júlio M.C. Morais.SETAC Europe 18th Annual Meeting, Warsaw, 25-29 May, 2008Warsaw, Polandnaonaosimacrc@uevora.ptsmbb@uevora.ptcmorais@uevora.pt365Costa, AnaBranco, SandraMorais, Júlioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:41:55Zoai:dspace.uevora.pt:10174/4151Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:59:28.717230Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats |
title |
Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats |
spellingShingle |
Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats Costa, Ana Tributyltin Rat glycaemia |
title_short |
Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats |
title_full |
Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats |
title_fullStr |
Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats |
title_full_unstemmed |
Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats |
title_sort |
Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats |
author |
Costa, Ana |
author_facet |
Costa, Ana Branco, Sandra Morais, Júlio |
author_role |
author |
author2 |
Branco, Sandra Morais, Júlio |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Costa, Ana Branco, Sandra Morais, Júlio |
dc.subject.por.fl_str_mv |
Tributyltin Rat glycaemia |
topic |
Tributyltin Rat glycaemia |
description |
Tributyltin chloride is still a relevant water and seafood pollutant, as reported for some sites of Mediterranean and Iberian coastal waters. We evaluated TBT metabolic effect in Wistar male rats, after administration of a repeated oral dose of 8.5mg/L in ethanol 0.25%, during 28 days, according to DIR96/54/EC. Groups of six animals, individually caged, were daily observed for fast blood glycaemia and semi-quantitative urine analysis. Glycaemic levels were significantly lower on the test group along the assay, showing a tendency for fasting hypoglycaemia. Urine analysis showed the presence of ketonic bodies in test group during the treatment. At the end of test period, animals were euthanized and serum analysis was performed revealing a significant increment of cholesterol and HDL-cholesterol (9.3% and 6.7%, respectively) and a non-significant increment on triglycerides content. These results suggest that TBT disrupted glucose and lipid homeostasis. Accordingly, and considering TBT a new member of environmental obesogen family, it is most relevant to reassess the effect of chronic exposure to low doses of this pollutant. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-05-01T00:00:00Z 2012-01-25T12:51:37Z 2012-01-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/4151 http://hdl.handle.net/10174/4151 |
url |
http://hdl.handle.net/10174/4151 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Tributyltin chloride disrupts glucose and lipid homeostasis on Wistar male rats. Ana C.R. Costa, Sandra M. Branco, Júlio M.C. Morais.SETAC Europe 18th Annual Meeting, Warsaw, 25-29 May, 2008 Warsaw, Poland nao nao sim acrc@uevora.pt smbb@uevora.pt cmorais@uevora.pt 365 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
SETAC Europe 18th Annual Meeting |
publisher.none.fl_str_mv |
SETAC Europe 18th Annual Meeting |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136477577216000 |