Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens

Detalhes bibliográficos
Autor(a) principal: Pinteus, Susete
Data de Publicação: 2020
Outros Autores: Lemos, Marco F.L., Simões, Marco, Alves, Celso, Silva, Joana, Gaspar, Helena, Martins, Alice, Rodrigues, Américo, Pedrosa, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/6129
Resumo: Authors would like to acknowledge the financial support of the Portuguese Foundation for Science and Technology (FCT) through Strategic Project UID/MAR/04292/2020 and UID/Multi/04046/2020 granted to MARE – Marine and Environmental Sciences Centre, Red2Discovery Project (PTDC/MAR-BIO/6149/2014), co-financed by COMPETE (POCI-01-0145-FEDER-016791); MARINE INVADERS Project (PTDC/BIA-CBI/31144/2017), co-financed by COMPETE (POCI-01-0145-FEDER-031144); VALORMAR (Mobilizing R&TD Programs, Portugal 2020) co-funded by COMPETE (POCI-01-0247- FEDER-024517); SAICTPAC/0019/2015 - LISBOA-01-0145-FEDER016405 Oncologia de Precisão: Terapias e Tecnologias Inovadoras (POINT4PAC) and CrossAtlantic project (PTDC/BIA-OUT/29250/ 2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250). This work was also supported by the European Union through EASME Blue Labs project AMALIA—Algae-to-MArket Lab IdeAs (EASME/EMFF/ 2016/1.2.1.4/03/SI2.750419) and the Integrated Programme of SR& TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 Program, Portugal 2020, European Union, through the European Regional Development Fund and by UIDB/04046/2020 and UIDP/04046/2020 Centre grants from FCT, Portugal (to BioISI). Susete Pinteus and Joana Silva were supported by FCT grants SFRH/BD/ 96203/2013 and SFRH/BD/103255/2014, respectively.
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spelling Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogensBacterial biofilmsInfectious diseasesMarine invadersMarine natural productsMicrobial resistanceSeaweed bioactive compoundsAuthors would like to acknowledge the financial support of the Portuguese Foundation for Science and Technology (FCT) through Strategic Project UID/MAR/04292/2020 and UID/Multi/04046/2020 granted to MARE – Marine and Environmental Sciences Centre, Red2Discovery Project (PTDC/MAR-BIO/6149/2014), co-financed by COMPETE (POCI-01-0145-FEDER-016791); MARINE INVADERS Project (PTDC/BIA-CBI/31144/2017), co-financed by COMPETE (POCI-01-0145-FEDER-031144); VALORMAR (Mobilizing R&TD Programs, Portugal 2020) co-funded by COMPETE (POCI-01-0247- FEDER-024517); SAICTPAC/0019/2015 - LISBOA-01-0145-FEDER016405 Oncologia de Precisão: Terapias e Tecnologias Inovadoras (POINT4PAC) and CrossAtlantic project (PTDC/BIA-OUT/29250/ 2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250). This work was also supported by the European Union through EASME Blue Labs project AMALIA—Algae-to-MArket Lab IdeAs (EASME/EMFF/ 2016/1.2.1.4/03/SI2.750419) and the Integrated Programme of SR& TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 Program, Portugal 2020, European Union, through the European Regional Development Fund and by UIDB/04046/2020 and UIDP/04046/2020 Centre grants from FCT, Portugal (to BioISI). Susete Pinteus and Joana Silva were supported by FCT grants SFRH/BD/ 96203/2013 and SFRH/BD/103255/2014, respectively.Infectious diseases remain one of the leading global causes of death, mainly due to the increasing number of multi-resistant microorganisms. Therefore, novel antimicrobials are continuously needed. Marine organisms have already proven to be a rich source of bioactive compounds which can be used for the development of novel pharmacological drugs. Within these, seaweeds are an important resource still underexplored. Asparagopsis armata is a marine invasive seaweed that has spread along several coastlines of the world, inducing negative pressures in marine ecosystems. Therefore, it is crucial to develop strategies to counteract their impacts. In this work, A. armata was extracted with methanol and dichloromethane (1:1) and fractionated by column chromatography with different polarity solvents, providing 8 fractions (F1-F8). All the fractions were evaluated for their antimicrobial potential against important human pathogens, namely Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis, and Candida albicans. Additionally, their capacity to inhibit biofilms formation and the effects on cytoplasmatic membrane and DNA integrity were also assessed. The most active fractions were further purified and submitted to GC–MS analysis. The results showed that A. armata produces compounds with a high inhibitory activity against S. aureus, P. aeruginosa, and C. albicans growth, possibly mediated by cytoplasmatic membrane disruption and DNA damage. GC–MS analysis suggested that the most active fractions were mainly composed of bromoditerpenes and fatty acids. The attained results point to the relevance of the invasive A. armata as a source of antimicrobial substances with broad-spectrum activity. The use of invasive species to obtain natural bioactive compounds presents a two-folded opportunity - high availability of the biological material for the extraction of bioactive compounds and, through specimen collection, the mitigation of the negative effects caused by invasive species, contributing to ecosystem integrity and sustainability.ElsevierIC-OnlinePinteus, SuseteLemos, Marco F.L.Simões, MarcoAlves, CelsoSilva, JoanaGaspar, HelenaMartins, AliceRodrigues, AméricoPedrosa, Rui2021-08-20T14:31:14Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/6129engSusete Pinteus, Marco F.L. Lemos, Marco Simões, Celso Alves, Joana Silva, Helena Gaspar, Alice Martins, Américo Rodrigues, Rui Pedrosa, Marine invasive species for high-value products' exploration – Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens, Algal Research, Volume 52, 2020, 102091, ISSN 2211-9264, https://doi.org/10.1016/j.algal.2020.102091.2211-926410.1016/j.algal.2020.102091metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-26T18:20:19Zoai:iconline.ipleiria.pt:10400.8/6129Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-26T18:20:19Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens
title Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens
spellingShingle Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens
Pinteus, Susete
Bacterial biofilms
Infectious diseases
Marine invaders
Marine natural products
Microbial resistance
Seaweed bioactive compounds
title_short Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens
title_full Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens
title_fullStr Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens
title_full_unstemmed Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens
title_sort Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens
author Pinteus, Susete
author_facet Pinteus, Susete
Lemos, Marco F.L.
Simões, Marco
Alves, Celso
Silva, Joana
Gaspar, Helena
Martins, Alice
Rodrigues, Américo
Pedrosa, Rui
author_role author
author2 Lemos, Marco F.L.
Simões, Marco
Alves, Celso
Silva, Joana
Gaspar, Helena
Martins, Alice
Rodrigues, Américo
Pedrosa, Rui
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Pinteus, Susete
Lemos, Marco F.L.
Simões, Marco
Alves, Celso
Silva, Joana
Gaspar, Helena
Martins, Alice
Rodrigues, Américo
Pedrosa, Rui
dc.subject.por.fl_str_mv Bacterial biofilms
Infectious diseases
Marine invaders
Marine natural products
Microbial resistance
Seaweed bioactive compounds
topic Bacterial biofilms
Infectious diseases
Marine invaders
Marine natural products
Microbial resistance
Seaweed bioactive compounds
description Authors would like to acknowledge the financial support of the Portuguese Foundation for Science and Technology (FCT) through Strategic Project UID/MAR/04292/2020 and UID/Multi/04046/2020 granted to MARE – Marine and Environmental Sciences Centre, Red2Discovery Project (PTDC/MAR-BIO/6149/2014), co-financed by COMPETE (POCI-01-0145-FEDER-016791); MARINE INVADERS Project (PTDC/BIA-CBI/31144/2017), co-financed by COMPETE (POCI-01-0145-FEDER-031144); VALORMAR (Mobilizing R&TD Programs, Portugal 2020) co-funded by COMPETE (POCI-01-0247- FEDER-024517); SAICTPAC/0019/2015 - LISBOA-01-0145-FEDER016405 Oncologia de Precisão: Terapias e Tecnologias Inovadoras (POINT4PAC) and CrossAtlantic project (PTDC/BIA-OUT/29250/ 2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250). This work was also supported by the European Union through EASME Blue Labs project AMALIA—Algae-to-MArket Lab IdeAs (EASME/EMFF/ 2016/1.2.1.4/03/SI2.750419) and the Integrated Programme of SR& TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 Program, Portugal 2020, European Union, through the European Regional Development Fund and by UIDB/04046/2020 and UIDP/04046/2020 Centre grants from FCT, Portugal (to BioISI). Susete Pinteus and Joana Silva were supported by FCT grants SFRH/BD/ 96203/2013 and SFRH/BD/103255/2014, respectively.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-08-20T14:31:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/6129
url http://hdl.handle.net/10400.8/6129
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Susete Pinteus, Marco F.L. Lemos, Marco Simões, Celso Alves, Joana Silva, Helena Gaspar, Alice Martins, Américo Rodrigues, Rui Pedrosa, Marine invasive species for high-value products' exploration – Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens, Algal Research, Volume 52, 2020, 102091, ISSN 2211-9264, https://doi.org/10.1016/j.algal.2020.102091.
2211-9264
10.1016/j.algal.2020.102091
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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