A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.7/683 |
Resumo: | This deposit is composed by the main article plus the supplementary materials of the publication. |
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A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and FibrosisMouse modelsFibrosisGenetically modified animalsCytokinesInflammationT cellsInflammatory diseasesSpleenThis deposit is composed by the main article plus the supplementary materials of the publication.Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic inflammation and fibrosis (N-IF) mouse. In the liver, the N-IF mouse displays inflammation and fibrosis particularly evident around portal tracts and central veins and accompanied with evidence of abnormal intrahepatic bile ducts. The extensive cellular infiltration consists mainly of macrophages, granulocytes, particularly eosinophils, and mast cells. This inflammatory syndrome is mediated by a transgenic population of natural killer T cells (NKT) induced in an immunodeficient NOD genetic background. The disease is transferrable to immunodeficient recipients, while polyclonal T cells from unaffected syngeneic donors can inhibit the disease phenotype. Because of the fibrotic component, early on-set, spontaneous nature and reproducibility, this novel mouse model provides a unique tool to gain further insight into the underlying mechanisms mediating transformation of chronic inflammation into fibrosis and to evaluate intervention protocols for treating conditions of fibrotic disorders.Vetenskapsrådet (VR) grant: (K2013-67X-07929- 27-3).PlosARCAFransén-Pettersson, NinaDuarte, NadiaNilsson, JuliaLundholm, MarieMayans, SofiaLarefalk, ÅsaHannibal, Tine DHansen, LisbethSchmidt-Christensen, AnjaIvars, FredrikCardell, SusannaPalmqvist, RichardRozell, BjörnHolmberg, Dan2016-08-11T14:54:58Z2016-07-212016-07-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/tiffapplication/mswordimage/tiffimage/tiffimage/tiffimage/tiffhttp://hdl.handle.net/10400.7/683engFransén-Pettersson N, Duarte N, Nilsson J, Lundholm M, Mayans S, Larefalk Å, et al. (2016) A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis. PLoS ONE 11(7): e0159850. doi:10.1371/journal.pone.015985010.1371/journal.pone.0159850info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:04Zoai:arca.igc.gulbenkian.pt:10400.7/683Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:55.110288Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis |
| title |
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis |
| spellingShingle |
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis Fransén-Pettersson, Nina Mouse models Fibrosis Genetically modified animals Cytokines Inflammation T cells Inflammatory diseases Spleen |
| title_short |
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis |
| title_full |
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis |
| title_fullStr |
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis |
| title_full_unstemmed |
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis |
| title_sort |
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis |
| author |
Fransén-Pettersson, Nina |
| author_facet |
Fransén-Pettersson, Nina Duarte, Nadia Nilsson, Julia Lundholm, Marie Mayans, Sofia Larefalk, Åsa Hannibal, Tine D Hansen, Lisbeth Schmidt-Christensen, Anja Ivars, Fredrik Cardell, Susanna Palmqvist, Richard Rozell, Björn Holmberg, Dan |
| author_role |
author |
| author2 |
Duarte, Nadia Nilsson, Julia Lundholm, Marie Mayans, Sofia Larefalk, Åsa Hannibal, Tine D Hansen, Lisbeth Schmidt-Christensen, Anja Ivars, Fredrik Cardell, Susanna Palmqvist, Richard Rozell, Björn Holmberg, Dan |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
ARCA |
| dc.contributor.author.fl_str_mv |
Fransén-Pettersson, Nina Duarte, Nadia Nilsson, Julia Lundholm, Marie Mayans, Sofia Larefalk, Åsa Hannibal, Tine D Hansen, Lisbeth Schmidt-Christensen, Anja Ivars, Fredrik Cardell, Susanna Palmqvist, Richard Rozell, Björn Holmberg, Dan |
| dc.subject.por.fl_str_mv |
Mouse models Fibrosis Genetically modified animals Cytokines Inflammation T cells Inflammatory diseases Spleen |
| topic |
Mouse models Fibrosis Genetically modified animals Cytokines Inflammation T cells Inflammatory diseases Spleen |
| description |
This deposit is composed by the main article plus the supplementary materials of the publication. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-08-11T14:54:58Z 2016-07-21 2016-07-21T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/683 |
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http://hdl.handle.net/10400.7/683 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Fransén-Pettersson N, Duarte N, Nilsson J, Lundholm M, Mayans S, Larefalk Å, et al. (2016) A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis. PLoS ONE 11(7): e0159850. doi:10.1371/journal.pone.0159850 10.1371/journal.pone.0159850 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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