Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871 |
Resumo: | Introduction: Optic disc hypoplasia is a common feature in fetal alcohol syndrome. Thus, we aimed to evaluate the optic disc morphology changes and the peripapillary retinal nerve fiber layer thickness in these patients. Material and Methods: We performed spectral-domain optical coherence tomography in a cohort of 11 patients (22 eyes) with fetal alcohol syndrome and in an age-matched control group. We evaluated optic nerve head parameters (optic disc area and diameter, rim area, cup/disc horizontal and vertical ratios) and peripapillary retinal nerve fiber layer thickness.Results: Mean optic disc area, rim area and optic disc diameter were, respectively, in fetal alcohol syndrome patients and control subjects: 1.540 ± 0.268 and 1.748 ± 0.326 mm2; 1.205 ± 0.286 and 1.461 ± 0.314 mm2; 1.417 ± 0.124 and 1.501 ± 0.148 mm (p < 0.05). We found no significant differences between groups for cup/disc ratios. Mean retinal nerve fiber layer thickness was significantly lower in fetal alcohol syndrome patients (90.500 ± 9.344 µm) as compared to controls (111.000 ± 7.855 µm) (p < 0.0001). Analysis showed a significant decrease in retinal nerve fiber layer thickness for the superior, inferior and nasal quadrants (p < 0.005). The temporal quadrant showed no significant differences.Discussion: Optic disc area, rim area and optic disc diameters were significantly reduced in fetal alcohol syndrome patients. Although mean peripapillary retinal nerve fiber layer thickness was decreased, the temporal quadrant was spared.Conclusion: In addition to a smaller optic disc area/ diameter and rim area, we found a heterogeneous peripapillary retinal nerve fiber layer thickness loss in fetal alcohol syndrome patients with sparing of the temporal quadrant. Spectral-domain optical coherence tomography may be useful to determine the presence of fetal alcohol syndrome status. |
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Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography AnalysisPadrão de Perda da Espessura da Camada de Fibras Nervosas da Retina na Síndrome Fetal-Alcoólica: Análise com Tomografia de Coerência Ótica de Domínio EspectralFetal Alcohol Spectrum DisordersOptic Nerve DiseasesNerve FibersRetina.Doenças do Nervo ÓpticoFibras NervosasRetinaTomografia de Coerência ÓpticaTranstornos do Espectro Alcoólico Fetal.Introduction: Optic disc hypoplasia is a common feature in fetal alcohol syndrome. Thus, we aimed to evaluate the optic disc morphology changes and the peripapillary retinal nerve fiber layer thickness in these patients. Material and Methods: We performed spectral-domain optical coherence tomography in a cohort of 11 patients (22 eyes) with fetal alcohol syndrome and in an age-matched control group. We evaluated optic nerve head parameters (optic disc area and diameter, rim area, cup/disc horizontal and vertical ratios) and peripapillary retinal nerve fiber layer thickness.Results: Mean optic disc area, rim area and optic disc diameter were, respectively, in fetal alcohol syndrome patients and control subjects: 1.540 ± 0.268 and 1.748 ± 0.326 mm2; 1.205 ± 0.286 and 1.461 ± 0.314 mm2; 1.417 ± 0.124 and 1.501 ± 0.148 mm (p < 0.05). We found no significant differences between groups for cup/disc ratios. Mean retinal nerve fiber layer thickness was significantly lower in fetal alcohol syndrome patients (90.500 ± 9.344 µm) as compared to controls (111.000 ± 7.855 µm) (p < 0.0001). Analysis showed a significant decrease in retinal nerve fiber layer thickness for the superior, inferior and nasal quadrants (p < 0.005). The temporal quadrant showed no significant differences.Discussion: Optic disc area, rim area and optic disc diameters were significantly reduced in fetal alcohol syndrome patients. Although mean peripapillary retinal nerve fiber layer thickness was decreased, the temporal quadrant was spared.Conclusion: In addition to a smaller optic disc area/ diameter and rim area, we found a heterogeneous peripapillary retinal nerve fiber layer thickness loss in fetal alcohol syndrome patients with sparing of the temporal quadrant. Spectral-domain optical coherence tomography may be useful to determine the presence of fetal alcohol syndrome status.Introdução: A hipoplasia do disco ótico é característica comum na síndrome fetal-alcoólica. Assim, propusemo-nos a avaliar as alterações morfológicas do disco ótico e a espessura da camada de fibras nervosas retinianas peripapilares, nunca antes estudada nestes doentes. Material e Métodos: Realizamos tomografia de coerência óptica de domínio espectral num grupo de 11 doentes (22 olhos) com síndrome fetal-alcoólica e num grupo controlo ajustado à idade. Avaliamos alguns parâmetros morfológicos do disco ótico (área e diâmetro do disco ótico, área do anel neurorretiniano, razão escavação/disco horizontal e vertical) e a espessura da camada de fibras nervosas retiniana peripapilares.Resultados: Os valores médios da área do disco ótico, anel neurorretiniano e diâmetro do disco ótico foram, respetivamente, no grupo de doentes e no grupo controlo: 1,540 ± 0,268 e 1,748 ± 0,326 mm2; 1,205 ± 0,286 e 1,461 ± 0,314 mm2; 1,417 ± 0,124 e 1,501 ± 0,148 mm (p < 0,05). Não encontramos diferenças significativas entre as razões escavação/disco. A espessura média da camada de fibras nervosas foi significativamente menor nos pacientes (90,500 ± 9,344 µm) relativamente aos controlos (111,000 ± 7,855 µm) (p < 0,0001). Verificamos uma diminuição significativa nos quadrantes superior, inferior e nasal (p < 0,005). O quadrante temporal não revelou diferenças significativas.Discussão: As áreas do disco ótico e anel neurorretiniano e o diâmetro do disco ótico foram significativamente menores nos pacientes com síndrome fetal-alcoólica. Embora a espessura média da camada de fibras nervosas peripapilares se tenha revelado diminuída, o quadrante temporal parece estar poupado.Conclusão: Para além de uma área/ diâmetro do disco ótico e área do anel neurorretiniano menores, descobrimos um padrão heterogéneo de perda da camada de fibras nervosas retinianas peripapilares em pacientes com síndrome fetal-alcoólica, sem atingimento do quadrante temporal. A tomografia de coerência óptica poderá ser útil no estabelecimento do diagnóstico da síndrome fetal-alcoólica.Ordem dos Médicos2016-04-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/jpegapplication/mswordimage/jpegimage/jpegimage/jpegapplication/mswordapplication/mswordimage/jpegimage/jpegimage/jpegimage/jpeghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871oai:ojs.www.actamedicaportuguesa.com:article/6871Acta Médica Portuguesa; Vol. 29 No. 4 (2016): April; 254-260Acta Médica Portuguesa; Vol. 29 N.º 4 (2016): Abril; 254-2601646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/4653https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/7807https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/7808https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/7809https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/7810https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/7811https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8036https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8037https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8356https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8357https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8358https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8359Direitos de Autor (c) 2016 Acta Médica Portuguesa - Ordem dos Médicosinfo:eu-repo/semantics/openAccessMenezes, CarlosRibeiro, IsabelCoelho, PedroMateus, CatarinaTeixeira, Carla2022-12-20T11:05:01Zoai:ojs.www.actamedicaportuguesa.com:article/6871Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:22.819381Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis Padrão de Perda da Espessura da Camada de Fibras Nervosas da Retina na Síndrome Fetal-Alcoólica: Análise com Tomografia de Coerência Ótica de Domínio Espectral |
title |
Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis |
spellingShingle |
Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis Menezes, Carlos Fetal Alcohol Spectrum Disorders Optic Nerve Diseases Nerve Fibers Retina. Doenças do Nervo Óptico Fibras Nervosas Retina Tomografia de Coerência Óptica Transtornos do Espectro Alcoólico Fetal. |
title_short |
Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis |
title_full |
Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis |
title_fullStr |
Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis |
title_full_unstemmed |
Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis |
title_sort |
Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis |
author |
Menezes, Carlos |
author_facet |
Menezes, Carlos Ribeiro, Isabel Coelho, Pedro Mateus, Catarina Teixeira, Carla |
author_role |
author |
author2 |
Ribeiro, Isabel Coelho, Pedro Mateus, Catarina Teixeira, Carla |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Menezes, Carlos Ribeiro, Isabel Coelho, Pedro Mateus, Catarina Teixeira, Carla |
dc.subject.por.fl_str_mv |
Fetal Alcohol Spectrum Disorders Optic Nerve Diseases Nerve Fibers Retina. Doenças do Nervo Óptico Fibras Nervosas Retina Tomografia de Coerência Óptica Transtornos do Espectro Alcoólico Fetal. |
topic |
Fetal Alcohol Spectrum Disorders Optic Nerve Diseases Nerve Fibers Retina. Doenças do Nervo Óptico Fibras Nervosas Retina Tomografia de Coerência Óptica Transtornos do Espectro Alcoólico Fetal. |
description |
Introduction: Optic disc hypoplasia is a common feature in fetal alcohol syndrome. Thus, we aimed to evaluate the optic disc morphology changes and the peripapillary retinal nerve fiber layer thickness in these patients. Material and Methods: We performed spectral-domain optical coherence tomography in a cohort of 11 patients (22 eyes) with fetal alcohol syndrome and in an age-matched control group. We evaluated optic nerve head parameters (optic disc area and diameter, rim area, cup/disc horizontal and vertical ratios) and peripapillary retinal nerve fiber layer thickness.Results: Mean optic disc area, rim area and optic disc diameter were, respectively, in fetal alcohol syndrome patients and control subjects: 1.540 ± 0.268 and 1.748 ± 0.326 mm2; 1.205 ± 0.286 and 1.461 ± 0.314 mm2; 1.417 ± 0.124 and 1.501 ± 0.148 mm (p < 0.05). We found no significant differences between groups for cup/disc ratios. Mean retinal nerve fiber layer thickness was significantly lower in fetal alcohol syndrome patients (90.500 ± 9.344 µm) as compared to controls (111.000 ± 7.855 µm) (p < 0.0001). Analysis showed a significant decrease in retinal nerve fiber layer thickness for the superior, inferior and nasal quadrants (p < 0.005). The temporal quadrant showed no significant differences.Discussion: Optic disc area, rim area and optic disc diameters were significantly reduced in fetal alcohol syndrome patients. Although mean peripapillary retinal nerve fiber layer thickness was decreased, the temporal quadrant was spared.Conclusion: In addition to a smaller optic disc area/ diameter and rim area, we found a heterogeneous peripapillary retinal nerve fiber layer thickness loss in fetal alcohol syndrome patients with sparing of the temporal quadrant. Spectral-domain optical coherence tomography may be useful to determine the presence of fetal alcohol syndrome status. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04-29 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871 oai:ojs.www.actamedicaportuguesa.com:article/6871 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/6871 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/4653 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/7807 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/7808 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/7809 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/7810 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/7811 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8036 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8037 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8356 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8357 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8358 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6871/8359 |
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Direitos de Autor (c) 2016 Acta Médica Portuguesa - Ordem dos Médicos info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2016 Acta Médica Portuguesa - Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 29 No. 4 (2016): April; 254-260 Acta Médica Portuguesa; Vol. 29 N.º 4 (2016): Abril; 254-260 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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