Chronic stress disrupts neural coherence between cortico-limbic structures
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/24172 |
Resumo: | The authors would like to thank Rui Gomes for the help in the application of electrophysio- logical techniques and Luís Martins and Miguel Carneiro for the histological preparations. |
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Chronic stress disrupts neural coherence between cortico-limbic structuresChronic stressCoherencePower spectrumHippocampusPrefrontal cortexScience & TechnologyThe authors would like to thank Rui Gomes for the help in the application of electrophysio- logical techniques and Luís Martins and Miguel Carneiro for the histological preparations.Chronic stress impairs cognitive function, namely on tasks that rely on the integrity of cortico-limbic networks. To unravel the functional impact of progressive stress in cortico-limbic networks we measured neural activity and spectral coherences between the ventral hippocampus (vHIP) and the medial prefrontal cortex (mPFC) in rats subjected to short term stress (STS) and chronic unpredictable stress (CUS). CUS exposure consistently disrupted the spectral coherence between both areas for a wide range of frequencies, whereas STS exposure failed to trigger such effect. The chronic stress-induced coherence decrease correlated inversely with the vHIP power spectrum, but not with the mPFC power spectrum, which supports the view that hippocampal dysfunction is the primary event after stress exposure. Importantly, we additionally show that the variations in vHIP-to-mPFC coherence and power spectrum in the vHIP correlated with stress-induced behavioral deficits in a spatial reference memory task. Altogether, these findings result in an innovative readout to measure, and follow, the functional events that underlie the stress-induced reference memory impairments.The authors work was supported by FEDER funds through Operational program for competivity factors—COMPETE and by national funds through FCT—Foundation for Science and Technology (FCT) fellowships (João Filipe Oliveira by SFRH/BPD/66151/2009; Luís Ricardo Jacinto by SFRH/BD/40459/2007), a Marie Curie Fellowship (João Filipe Oliveira by PIEF-GA-2010-273936) and Grants from BIAL Foundation (138/2008 to João José Cerqueira and 61/2010 to João Filipe Oliveira and Vanessa Morais Sardinha) and FCT (João Filipe Oliveira, Ana Lima, and Ana Filipa Oliveira by PTDC/SAU- NSC/118194/2010; Nuno Sérgio Dias, Luís Ricardo Jacinto, João José Cerqueira, and Nuno Sousa by FCT/PTDC/SAU- ENB/118383/2010; Nuno Sérgio Dias, Daniela Silva Ferreira, Joana Santos Reis, João José Cerqueira, and Nuno Sousa by FCOMP-01-0124-FEDER-022674).Frontiers MediaUniversidade do MinhoOliveira, João F.Dias, N. S.Correia, MarianaPereira, Filipa GamaSardinha, Vanessa MoraisLima, Ana RaquelOliveira, Ana Filipa MartinsJacinto, L. R.Ferreira, DanielaSilva, AnaReis, Joana Vanessa Santos dosCerqueira, JoãoSousa, Nuno2013-022013-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24172engOliveira JF, Dias NS, Correia M, Gama-Pereira F, Sardinha VM, Lima A, Oliveira AF, Jacinto LR, Ferreira DS, Silva AM, Reis JS, Cerqueira JJ and Sousa N (2013) Chronic stress disrupts neural coherence between cortico-limbic structures. Front. Neural Circuits 7:10. doi: 10.3389/fncir.2013.000101662-511010.3389/fncir.2013.00010http://dx.doi.org/10.3389/fncir.2013.00010info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:56:09Zoai:repositorium.sdum.uminho.pt:1822/24172Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:45:46.109899Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Chronic stress disrupts neural coherence between cortico-limbic structures |
| title |
Chronic stress disrupts neural coherence between cortico-limbic structures |
| spellingShingle |
Chronic stress disrupts neural coherence between cortico-limbic structures Oliveira, João F. Chronic stress Coherence Power spectrum Hippocampus Prefrontal cortex Science & Technology |
| title_short |
Chronic stress disrupts neural coherence between cortico-limbic structures |
| title_full |
Chronic stress disrupts neural coherence between cortico-limbic structures |
| title_fullStr |
Chronic stress disrupts neural coherence between cortico-limbic structures |
| title_full_unstemmed |
Chronic stress disrupts neural coherence between cortico-limbic structures |
| title_sort |
Chronic stress disrupts neural coherence between cortico-limbic structures |
| author |
Oliveira, João F. |
| author_facet |
Oliveira, João F. Dias, N. S. Correia, Mariana Pereira, Filipa Gama Sardinha, Vanessa Morais Lima, Ana Raquel Oliveira, Ana Filipa Martins Jacinto, L. R. Ferreira, Daniela Silva, Ana Reis, Joana Vanessa Santos dos Cerqueira, João Sousa, Nuno |
| author_role |
author |
| author2 |
Dias, N. S. Correia, Mariana Pereira, Filipa Gama Sardinha, Vanessa Morais Lima, Ana Raquel Oliveira, Ana Filipa Martins Jacinto, L. R. Ferreira, Daniela Silva, Ana Reis, Joana Vanessa Santos dos Cerqueira, João Sousa, Nuno |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Oliveira, João F. Dias, N. S. Correia, Mariana Pereira, Filipa Gama Sardinha, Vanessa Morais Lima, Ana Raquel Oliveira, Ana Filipa Martins Jacinto, L. R. Ferreira, Daniela Silva, Ana Reis, Joana Vanessa Santos dos Cerqueira, João Sousa, Nuno |
| dc.subject.por.fl_str_mv |
Chronic stress Coherence Power spectrum Hippocampus Prefrontal cortex Science & Technology |
| topic |
Chronic stress Coherence Power spectrum Hippocampus Prefrontal cortex Science & Technology |
| description |
The authors would like to thank Rui Gomes for the help in the application of electrophysio- logical techniques and Luís Martins and Miguel Carneiro for the histological preparations. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013-02 2013-02-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/24172 |
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http://hdl.handle.net/1822/24172 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Oliveira JF, Dias NS, Correia M, Gama-Pereira F, Sardinha VM, Lima A, Oliveira AF, Jacinto LR, Ferreira DS, Silva AM, Reis JS, Cerqueira JJ and Sousa N (2013) Chronic stress disrupts neural coherence between cortico-limbic structures. Front. Neural Circuits 7:10. doi: 10.3389/fncir.2013.00010 1662-5110 10.3389/fncir.2013.00010 http://dx.doi.org/10.3389/fncir.2013.00010 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
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Frontiers Media |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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