Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing

Detalhes bibliográficos
Autor(a) principal: Staats, Richard
Data de Publicação: 2017
Outros Autores: Rodrigues, Raquel, Barros, André, Nicolau, Leonor Bacelar, Aguiar, Margarida, Fernandes, Dina, Moreira, Susana, Simões, André, Silva-Santos, Bruno, Rodrigues, João Valença, Barbara, Cristina, Almeida, António Bugalho de, Moita, Luis Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/30176
Resumo: © The Author(s) 2017 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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spelling Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathingSleep-related breathing disordersObstructive sleep apneaPerforin and granzyme-B-positive peripheral blood lymphocytesCancerObesity© The Author(s) 2017 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Introduction: Sleep related breathing disorders (SRBD) cause sleep fragmentation, intermittent hypoxia or a combination of both leading to homeostasis perturbations, including in the immune system. We investigated whether SRBD patients with or without intermittent hypoxia show substantial differences in perforin and granzyme-B positive peripheral blood lymphocytes. Methods: A total of 87 subjects were included and distributed as follows: 24 controls (C), 19 patients with respiratory effort related arousals due to increased upper airway resistance (UAR) without hypoxic events, 24 obese patients with obstructive sleep apnea (OSA) (oOSA), and 20 without obesity (noOSA). After olysomnographic recording, we analyzed in fasting blood samples routine hematologic and biochemical parameters and the percentage of lymphocytes containing the proteins perforin and granzyme-B (GrB). Kruskal-Wallis tests and a posteriori multiple comparisons were applied for statistical analysis of results. Results: Perforin-positive γδ-cells revealed significant differences between groups (p = 0.017), especially between the Control group and the oOSA (p-value = 0.04); the remaining SRBD groups also showed differences from the control (C vs UAR: p = 0.08; C vs noOSA = 0.09), but they did not raise to statistical significance. There were no differences among the SRBD groups. Granzyme-B cells were decreased in SRBD patients, but the differences were not statistically significant. No additional statistical significant result was found in the other investigated lymphocyte subsets. Conclusions: Obstructive sleep-disordered breathing is associated with a decrease in perforin-positive CD3+γδ-T cells. Although this finding was detected in lean patients without intermittent hypoxia, the reduction was only statistically significant in obese patients with severe OSA. Because CD3+γδ-T cells play an important role in the control of tumor cells, our findings are directly relevant for the study of the association of OSA and cancer.LFM directs the Innate Immunity and Inflammation Laboratory at IGC, is an FCT Investigator and receives financial support from Fundação para a Ciência e Tecnologia (FCT) and the European Research Council (ERC-2014-CoG 647,888-iPROTECTION). The sponsors had no role in the design or conduct of this research.SpringerRepositório da Universidade de LisboaStaats, RichardRodrigues, RaquelBarros, AndréNicolau, Leonor BacelarAguiar, MargaridaFernandes, DinaMoreira, SusanaSimões, AndréSilva-Santos, BrunoRodrigues, João ValençaBarbara, CristinaAlmeida, António Bugalho deMoita, Luis Ferreira2017-12-21T16:47:47Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/30176engSleep Breath (2017)1522-170910.1007/s11325-017-1602-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:22:49Zoai:repositorio.ul.pt:10451/30176Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:45:55.026892Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing
title Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing
spellingShingle Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing
Staats, Richard
Sleep-related breathing disorders
Obstructive sleep apnea
Perforin and granzyme-B-positive peripheral blood lymphocytes
Cancer
Obesity
title_short Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing
title_full Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing
title_fullStr Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing
title_full_unstemmed Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing
title_sort Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing
author Staats, Richard
author_facet Staats, Richard
Rodrigues, Raquel
Barros, André
Nicolau, Leonor Bacelar
Aguiar, Margarida
Fernandes, Dina
Moreira, Susana
Simões, André
Silva-Santos, Bruno
Rodrigues, João Valença
Barbara, Cristina
Almeida, António Bugalho de
Moita, Luis Ferreira
author_role author
author2 Rodrigues, Raquel
Barros, André
Nicolau, Leonor Bacelar
Aguiar, Margarida
Fernandes, Dina
Moreira, Susana
Simões, André
Silva-Santos, Bruno
Rodrigues, João Valença
Barbara, Cristina
Almeida, António Bugalho de
Moita, Luis Ferreira
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Staats, Richard
Rodrigues, Raquel
Barros, André
Nicolau, Leonor Bacelar
Aguiar, Margarida
Fernandes, Dina
Moreira, Susana
Simões, André
Silva-Santos, Bruno
Rodrigues, João Valença
Barbara, Cristina
Almeida, António Bugalho de
Moita, Luis Ferreira
dc.subject.por.fl_str_mv Sleep-related breathing disorders
Obstructive sleep apnea
Perforin and granzyme-B-positive peripheral blood lymphocytes
Cancer
Obesity
topic Sleep-related breathing disorders
Obstructive sleep apnea
Perforin and granzyme-B-positive peripheral blood lymphocytes
Cancer
Obesity
description © The Author(s) 2017 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-21T16:47:47Z
2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/30176
url http://hdl.handle.net/10451/30176
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sleep Breath (2017)
1522-1709
10.1007/s11325-017-1602-6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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