Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.3/3182 |
Resumo: | Natural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demonstrated that xanthenedione derivative 5e, bearing a catechol unit, showed higher reduction capacity than BHT and similar to quercetin, strong DPPH scavenging activity (EC50 = 3.79 ± 0.06 μM) and it was also showed to be a potent AChEI (IC50 = 31.0 ± 0.09 μM) when compared to galantamine (IC50 = 211.8 ± 9.5 μM). |
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Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agentsXanthene-1,9(2H)-dionesXanthones3-cinnamoyl-5-hydroxy-2-styrylchromonesScavenging ActivityReduction PowerAcetylcholinesterase InhibitorsNatural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demonstrated that xanthenedione derivative 5e, bearing a catechol unit, showed higher reduction capacity than BHT and similar to quercetin, strong DPPH scavenging activity (EC50 = 3.79 ± 0.06 μM) and it was also showed to be a potent AChEI (IC50 = 31.0 ± 0.09 μM) when compared to galantamine (IC50 = 211.8 ± 9.5 μM).MDPIRepositório da Universidade dos AçoresSeca, Ana M. L.Leal, Stephanie B.Pinto, Diana C. G. A.Barreto, Maria do CarmoSilva, Artur M. S.2014-10-14T11:44:21Z2014-062014-09-22T10:07:47Z2014-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/3182engSeca, Ana; Leal, Stephanie; Pinto, Diana; Barreto, Maria; Silva, Artur (2014). "Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents", Molecules, 19(6), 8317-8333. Doi: 10.3390/molecules19068317.1420-304910.3390/molecules19068317info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:31:07Zoai:repositorio.uac.pt:10400.3/3182Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:25:46.292316Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents |
title |
Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents |
spellingShingle |
Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents Seca, Ana M. L. Xanthene-1,9(2H)-diones Xanthones 3-cinnamoyl-5-hydroxy-2-styrylchromones Scavenging Activity Reduction Power Acetylcholinesterase Inhibitors |
title_short |
Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents |
title_full |
Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents |
title_fullStr |
Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents |
title_full_unstemmed |
Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents |
title_sort |
Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents |
author |
Seca, Ana M. L. |
author_facet |
Seca, Ana M. L. Leal, Stephanie B. Pinto, Diana C. G. A. Barreto, Maria do Carmo Silva, Artur M. S. |
author_role |
author |
author2 |
Leal, Stephanie B. Pinto, Diana C. G. A. Barreto, Maria do Carmo Silva, Artur M. S. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade dos Açores |
dc.contributor.author.fl_str_mv |
Seca, Ana M. L. Leal, Stephanie B. Pinto, Diana C. G. A. Barreto, Maria do Carmo Silva, Artur M. S. |
dc.subject.por.fl_str_mv |
Xanthene-1,9(2H)-diones Xanthones 3-cinnamoyl-5-hydroxy-2-styrylchromones Scavenging Activity Reduction Power Acetylcholinesterase Inhibitors |
topic |
Xanthene-1,9(2H)-diones Xanthones 3-cinnamoyl-5-hydroxy-2-styrylchromones Scavenging Activity Reduction Power Acetylcholinesterase Inhibitors |
description |
Natural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demonstrated that xanthenedione derivative 5e, bearing a catechol unit, showed higher reduction capacity than BHT and similar to quercetin, strong DPPH scavenging activity (EC50 = 3.79 ± 0.06 μM) and it was also showed to be a potent AChEI (IC50 = 31.0 ± 0.09 μM) when compared to galantamine (IC50 = 211.8 ± 9.5 μM). |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-14T11:44:21Z 2014-06 2014-09-22T10:07:47Z 2014-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.3/3182 |
url |
http://hdl.handle.net/10400.3/3182 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Seca, Ana; Leal, Stephanie; Pinto, Diana; Barreto, Maria; Silva, Artur (2014). "Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents", Molecules, 19(6), 8317-8333. Doi: 10.3390/molecules19068317. 1420-3049 10.3390/molecules19068317 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130708533313536 |