Assembly of the Clostridioides difficile spore surface layers

• Autor(a) principal: Marini, Eleonora
• Data de Publicação: 2020
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/105568
• topic: exosporium; YabG gene; Molecular Biosciences

"Clostridioides difficile is a strict, anaerobic, gram-positive spore-forming bacterium and the leading cause, worldwide, of hospital acquired antibiotic associated diarrhea. It causes a range of intestinal conditions whose symptoms include mild diarrhea but also more serious and potentially life-threatening conditions including pseudomembranous colitis, toxin megacolon, bowel perforation and sepsis. The C. difficile infection cycle begins with the ingestion of spores. Once ingested, spores can germinate in the small intestine in response to bile salts, leading to the formation of a population of cells able to produce the two main virulence factors, the cytotoxins TcdA and TcdB, and more spores. Shedding of the oxygen-resistant spores into the environment allows dissemination of the organism and the infection of new hosts. (...)"