The color of fat and its central role in the development and progression of metabolic diseases
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/95081 https://doi.org/10.1515/hmbci-2017-0060 |
Resumo: | Excess caloric intake does not always translate to an expansion of the subcutaneous adipose tissue (SAT) and increase in fat mass. It is now recognized that adipocyte type (white, WAT, or brown, BAT), size (large vs. small) and metabolism are important factors for the development of cardiometabolic diseases. When the subcutaneous adipose tissue is not able to expand in response to increased energy intake the excess substrate is stored as visceral adipose tissue or as ectopic fat in tissues as muscle, liver and pancreas. Moreover, adipocytes become dysfunctional (adiposopathy, or sick fat), adipokines secretion is increased, fat accumulates in ectopic sites like muscle and liver and alters insulin signaling, increasing the demand for insulin secretion. Thus, there are some subjects that despite having normal weight have the metabolic characteristics of the obese (NWMO), while some obese expand their SAT and remain metabolically healthy (MHO). In this paper we have reviewed the recent findings that relate the metabolism of adipose tissue and its composition to metabolic diseases. In particular, we have discussed the possible role of dysfunctional adipocytes and adipose tissue resistance to the antilipolytic effect of insulin on the development of impaired glucose metabolism. Finally we have reviewed the possible role of BAT vs. WAT in the alteration of lipid and glucose metabolism and the recent studies that have tried to stimulate browning in human adipose tissue. |
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The color of fat and its central role in the development and progression of metabolic diseasesNAFLD; brown adipose tissue; insulin resistance; lipid metabolismAdipocytesAdipose TissueAdipose Tissue, BrownAdipose Tissue, WhiteDisease ProgressionGlucoseHumansInsulinInsulin ResistanceInsulin-Secreting CellsLipid MetabolismLipolysisMetabolic DiseasesDisease SusceptibilityExcess caloric intake does not always translate to an expansion of the subcutaneous adipose tissue (SAT) and increase in fat mass. It is now recognized that adipocyte type (white, WAT, or brown, BAT), size (large vs. small) and metabolism are important factors for the development of cardiometabolic diseases. When the subcutaneous adipose tissue is not able to expand in response to increased energy intake the excess substrate is stored as visceral adipose tissue or as ectopic fat in tissues as muscle, liver and pancreas. Moreover, adipocytes become dysfunctional (adiposopathy, or sick fat), adipokines secretion is increased, fat accumulates in ectopic sites like muscle and liver and alters insulin signaling, increasing the demand for insulin secretion. Thus, there are some subjects that despite having normal weight have the metabolic characteristics of the obese (NWMO), while some obese expand their SAT and remain metabolically healthy (MHO). In this paper we have reviewed the recent findings that relate the metabolism of adipose tissue and its composition to metabolic diseases. In particular, we have discussed the possible role of dysfunctional adipocytes and adipose tissue resistance to the antilipolytic effect of insulin on the development of impaired glucose metabolism. Finally we have reviewed the possible role of BAT vs. WAT in the alteration of lipid and glucose metabolism and the recent studies that have tried to stimulate browning in human adipose tissue.2017-09-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/95081http://hdl.handle.net/10316/95081https://doi.org/10.1515/hmbci-2017-0060eng1868-1891https://www.degruyter.com/document/doi/10.1515/hmbci-2017-0060/htmlGaggini, MelaniaCarli, FabriziaGastaldelli, Amaliainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-12-12T06:34:58Zoai:estudogeral.uc.pt:10316/95081Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:13:39.891366Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The color of fat and its central role in the development and progression of metabolic diseases |
title |
The color of fat and its central role in the development and progression of metabolic diseases |
spellingShingle |
The color of fat and its central role in the development and progression of metabolic diseases Gaggini, Melania NAFLD; brown adipose tissue; insulin resistance; lipid metabolism Adipocytes Adipose Tissue Adipose Tissue, Brown Adipose Tissue, White Disease Progression Glucose Humans Insulin Insulin Resistance Insulin-Secreting Cells Lipid Metabolism Lipolysis Metabolic Diseases Disease Susceptibility |
title_short |
The color of fat and its central role in the development and progression of metabolic diseases |
title_full |
The color of fat and its central role in the development and progression of metabolic diseases |
title_fullStr |
The color of fat and its central role in the development and progression of metabolic diseases |
title_full_unstemmed |
The color of fat and its central role in the development and progression of metabolic diseases |
title_sort |
The color of fat and its central role in the development and progression of metabolic diseases |
author |
Gaggini, Melania |
author_facet |
Gaggini, Melania Carli, Fabrizia Gastaldelli, Amalia |
author_role |
author |
author2 |
Carli, Fabrizia Gastaldelli, Amalia |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Gaggini, Melania Carli, Fabrizia Gastaldelli, Amalia |
dc.subject.por.fl_str_mv |
NAFLD; brown adipose tissue; insulin resistance; lipid metabolism Adipocytes Adipose Tissue Adipose Tissue, Brown Adipose Tissue, White Disease Progression Glucose Humans Insulin Insulin Resistance Insulin-Secreting Cells Lipid Metabolism Lipolysis Metabolic Diseases Disease Susceptibility |
topic |
NAFLD; brown adipose tissue; insulin resistance; lipid metabolism Adipocytes Adipose Tissue Adipose Tissue, Brown Adipose Tissue, White Disease Progression Glucose Humans Insulin Insulin Resistance Insulin-Secreting Cells Lipid Metabolism Lipolysis Metabolic Diseases Disease Susceptibility |
description |
Excess caloric intake does not always translate to an expansion of the subcutaneous adipose tissue (SAT) and increase in fat mass. It is now recognized that adipocyte type (white, WAT, or brown, BAT), size (large vs. small) and metabolism are important factors for the development of cardiometabolic diseases. When the subcutaneous adipose tissue is not able to expand in response to increased energy intake the excess substrate is stored as visceral adipose tissue or as ectopic fat in tissues as muscle, liver and pancreas. Moreover, adipocytes become dysfunctional (adiposopathy, or sick fat), adipokines secretion is increased, fat accumulates in ectopic sites like muscle and liver and alters insulin signaling, increasing the demand for insulin secretion. Thus, there are some subjects that despite having normal weight have the metabolic characteristics of the obese (NWMO), while some obese expand their SAT and remain metabolically healthy (MHO). In this paper we have reviewed the recent findings that relate the metabolism of adipose tissue and its composition to metabolic diseases. In particular, we have discussed the possible role of dysfunctional adipocytes and adipose tissue resistance to the antilipolytic effect of insulin on the development of impaired glucose metabolism. Finally we have reviewed the possible role of BAT vs. WAT in the alteration of lipid and glucose metabolism and the recent studies that have tried to stimulate browning in human adipose tissue. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/95081 http://hdl.handle.net/10316/95081 https://doi.org/10.1515/hmbci-2017-0060 |
url |
http://hdl.handle.net/10316/95081 https://doi.org/10.1515/hmbci-2017-0060 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1868-1891 https://www.degruyter.com/document/doi/10.1515/hmbci-2017-0060/html |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134032323149824 |