Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/62213 |
Resumo: | Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by robust burning and eczematous lacerations in diverse portions of the body. AD affects about 20% of both offspring and adults worldwide. The pathophysiology of AD combines environmental, hereditary, and immunological aspects, together with skin barrier dysfunction. The procedures used to prevent the disease are the everyday usage of creams to support the restoration of the epidermal barrier. The classical treatments include the use of topical corticosteroids as a first-line therapy, but also calcineurin inhibitors, antihistamines, antibiotics, phototherapy, and also immunosuppressant drugs in severe cases of AD. Topical drug delivery to deeper skin layers is a difficult task due to the skin anatomic barrier, which limits deeper penetration of drugs. Groundbreaking drug delivery systems, based on nanoparticles (NPs), have received much attention due to their ability to improve solubility, bioavailability, diffusion, targeting to specific types of cells, and limiting the secondary effects of the drugs employed in the treatment of AD. Even so, additional studies are still required to recognize the toxicological characteristics and long-term safety of NPs. This review discusses the current classical pharmacotherapy of AD against new nanoparticle skin delivery systems and their toxicologic risks. |
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Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systemsatopic dermatitisdrug delivery systemspharmacological treatmentnanotechnologynanoparticlesScience & TechnologyAtopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by robust burning and eczematous lacerations in diverse portions of the body. AD affects about 20% of both offspring and adults worldwide. The pathophysiology of AD combines environmental, hereditary, and immunological aspects, together with skin barrier dysfunction. The procedures used to prevent the disease are the everyday usage of creams to support the restoration of the epidermal barrier. The classical treatments include the use of topical corticosteroids as a first-line therapy, but also calcineurin inhibitors, antihistamines, antibiotics, phototherapy, and also immunosuppressant drugs in severe cases of AD. Topical drug delivery to deeper skin layers is a difficult task due to the skin anatomic barrier, which limits deeper penetration of drugs. Groundbreaking drug delivery systems, based on nanoparticles (NPs), have received much attention due to their ability to improve solubility, bioavailability, diffusion, targeting to specific types of cells, and limiting the secondary effects of the drugs employed in the treatment of AD. Even so, additional studies are still required to recognize the toxicological characteristics and long-term safety of NPs. This review discusses the current classical pharmacotherapy of AD against new nanoparticle skin delivery systems and their toxicologic risks.This work was financially supported by the Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project reference M-ERA-NET/0004/2015-PAIRED and UID/AGR/04033/2019 (CITAB), co-financed by FEDER, under the Partnership Agreement PT2020, and also by the Institute of Nanoscience and Nanotechnology under the project ART (2018).info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoSouto, Eliana B.Dias-Ferreira, JoãoOliveira, JéssicaSanchez-Lopez, ElenaLopez-Machado, AnaEspina, MartaGarcia, Maria L.Souto, Selma B.Martins-Gomes, CarlosSilva, Amélia M.2019-11-122019-11-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62213engSouto, Eliana; Dias-Ferreira, João; Oliveira, Jéssica; Sanchez-Lopez, Elena; Lopez-Machado, Ana; Espina, Marta; Garcia, Maria L.; Souto, Selma B.; Martins-Gomes, Carlos; Silva, Amélia M., Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems. International Journal of Molecular Sciences, 20(22), 5659, 20191424-67831422-00671661-659610.3390/ijms2022565931726723http://www.mdpi.com/journal/ijmsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:48:54Zoai:repositorium.sdum.uminho.pt:1822/62213Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:47:14.919462Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems |
title |
Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems |
spellingShingle |
Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems Souto, Eliana B. atopic dermatitis drug delivery systems pharmacological treatment nanotechnology nanoparticles Science & Technology |
title_short |
Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems |
title_full |
Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems |
title_fullStr |
Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems |
title_full_unstemmed |
Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems |
title_sort |
Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems |
author |
Souto, Eliana B. |
author_facet |
Souto, Eliana B. Dias-Ferreira, João Oliveira, Jéssica Sanchez-Lopez, Elena Lopez-Machado, Ana Espina, Marta Garcia, Maria L. Souto, Selma B. Martins-Gomes, Carlos Silva, Amélia M. |
author_role |
author |
author2 |
Dias-Ferreira, João Oliveira, Jéssica Sanchez-Lopez, Elena Lopez-Machado, Ana Espina, Marta Garcia, Maria L. Souto, Selma B. Martins-Gomes, Carlos Silva, Amélia M. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Souto, Eliana B. Dias-Ferreira, João Oliveira, Jéssica Sanchez-Lopez, Elena Lopez-Machado, Ana Espina, Marta Garcia, Maria L. Souto, Selma B. Martins-Gomes, Carlos Silva, Amélia M. |
dc.subject.por.fl_str_mv |
atopic dermatitis drug delivery systems pharmacological treatment nanotechnology nanoparticles Science & Technology |
topic |
atopic dermatitis drug delivery systems pharmacological treatment nanotechnology nanoparticles Science & Technology |
description |
Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by robust burning and eczematous lacerations in diverse portions of the body. AD affects about 20% of both offspring and adults worldwide. The pathophysiology of AD combines environmental, hereditary, and immunological aspects, together with skin barrier dysfunction. The procedures used to prevent the disease are the everyday usage of creams to support the restoration of the epidermal barrier. The classical treatments include the use of topical corticosteroids as a first-line therapy, but also calcineurin inhibitors, antihistamines, antibiotics, phototherapy, and also immunosuppressant drugs in severe cases of AD. Topical drug delivery to deeper skin layers is a difficult task due to the skin anatomic barrier, which limits deeper penetration of drugs. Groundbreaking drug delivery systems, based on nanoparticles (NPs), have received much attention due to their ability to improve solubility, bioavailability, diffusion, targeting to specific types of cells, and limiting the secondary effects of the drugs employed in the treatment of AD. Even so, additional studies are still required to recognize the toxicological characteristics and long-term safety of NPs. This review discusses the current classical pharmacotherapy of AD against new nanoparticle skin delivery systems and their toxicologic risks. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-12 2019-11-12T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/62213 |
url |
http://hdl.handle.net/1822/62213 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Souto, Eliana; Dias-Ferreira, João; Oliveira, Jéssica; Sanchez-Lopez, Elena; Lopez-Machado, Ana; Espina, Marta; Garcia, Maria L.; Souto, Selma B.; Martins-Gomes, Carlos; Silva, Amélia M., Trends in atopic dermatitis-from standard pharmacotherapy to novel drug delivery systems. International Journal of Molecular Sciences, 20(22), 5659, 2019 1424-6783 1422-0067 1661-6596 10.3390/ijms20225659 31726723 http://www.mdpi.com/journal/ijms |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133045787197440 |