Promising alternative therapeutics for oral candidiasis

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Célia F.
Data de Publicação: 2019
Outros Autores: Rodrigues, M. Elisa, Henriques, Mariana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/61266
Resumo: Candida is the main human fungal pathogen causing infections (candidiasis), mostly in the elderly and immunocompromised hosts. Even though Candida spp. is a member of the oral microbiota in symbiosis, in some circumstances, it can cause microbial imbalance leading to dysbiosis, resulting in oral diseases. Alternative therapies are urgently needed to treat oral candidiasis (usually associated to biofilms), as several antifungal drugs activity has been compromised. This has occurred especially due to an increasing occurrence of drugresistant in Candida spp. strains. The overuse of antifungal medications, systemic toxicity, cross-reactivity with other drugs and a presently low number of drug molecules with antifungal activity, have contributed to important clinical limitations. We undertook a structured search of bibliographic databases (PubMed Central, Elseviers ScienceDirect, SCOPUS and Springers SpringerLink) for peer-reviewed research literature using a focused review in the areas of alternatives to manage oral candidiasis. The keywords used were candidiasis, oral candidiasis, biofilm + candida, alternative treatment, combination therapy + candida and the reports from the last 10 to 15 years were considered for this review. This review identified several promising new approaches in the treatment of oral candidiasis: combination anti-Candida therapies, denture cleansers, mouth rinses as alternatives for disrupting candidal biofilms, natural compounds (e.g. honey, probiotics, plant extracts and essential oils) and photodynamic therapy. The findings of this review confirm the importance and the urgency of the development of efficacious therapies for oral candidal infections
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spelling Promising alternative therapeutics for oral candidiasisCandidaoral candidiasisresistanceantifungal treatmentplantshoneyprobioticsphotodynamic therapyScience & TechnologyCandida is the main human fungal pathogen causing infections (candidiasis), mostly in the elderly and immunocompromised hosts. Even though Candida spp. is a member of the oral microbiota in symbiosis, in some circumstances, it can cause microbial imbalance leading to dysbiosis, resulting in oral diseases. Alternative therapies are urgently needed to treat oral candidiasis (usually associated to biofilms), as several antifungal drugs activity has been compromised. This has occurred especially due to an increasing occurrence of drugresistant in Candida spp. strains. The overuse of antifungal medications, systemic toxicity, cross-reactivity with other drugs and a presently low number of drug molecules with antifungal activity, have contributed to important clinical limitations. We undertook a structured search of bibliographic databases (PubMed Central, Elseviers ScienceDirect, SCOPUS and Springers SpringerLink) for peer-reviewed research literature using a focused review in the areas of alternatives to manage oral candidiasis. The keywords used were candidiasis, oral candidiasis, biofilm + candida, alternative treatment, combination therapy + candida and the reports from the last 10 to 15 years were considered for this review. This review identified several promising new approaches in the treatment of oral candidiasis: combination anti-Candida therapies, denture cleansers, mouth rinses as alternatives for disrupting candidal biofilms, natural compounds (e.g. honey, probiotics, plant extracts and essential oils) and photodynamic therapy. The findings of this review confirm the importance and the urgency of the development of efficacious therapies for oral candidal infectionsThis study was supported by the Portuguese Foun- dation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER- 006684) and BioTecNorte operation (NORTE-01- 0145-FEDER-000004) funded by the European Re- gional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte and Célia F. Rodrigues’ [SFRH/BD/93078/2013] PhD grant and M. Elisa Rodrigues’ [SFRH/BPD/95401/2013] post-doc grant. C.F.R. also would like to thank the project UID/EQU/00511/2019-Laboratory for Process Engineering, Environment, Biotechnology and EnergyLEPABE funded by national funds through FCT/MCTES (PIDDAC). Célia F. Rodrigues also thank the project UID/EQU/00511/2019-Laboratory for Process Engineering, Environment, Biotechnology and Energy-LEPABE funded by national funds through FCT/MCTES (PIDDAC).info:eu-repo/semantics/publishedVersionBentham Science PublishersUniversidade do MinhoRodrigues, Célia F.Rodrigues, M. ElisaHenriques, Mariana20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61266engRodrigues, Célia F.; Rodrigues, M. Elisa; Henriques, Mariana, Promising alternative therapeutics for oral candidiasis. Current Medicinal Chemistry, 26(14), 2515-2528, 2019092986731875533X10.2174/092986732566618060110233329852856http://benthamscience.com/journals/current-medicinal-chemistry/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:24:05Zoai:repositorium.sdum.uminho.pt:1822/61266Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:17:58.621320Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Promising alternative therapeutics for oral candidiasis
title Promising alternative therapeutics for oral candidiasis
spellingShingle Promising alternative therapeutics for oral candidiasis
Rodrigues, Célia F.
Candida
oral candidiasis
resistance
antifungal treatment
plants
honey
probiotics
photodynamic therapy
Science & Technology
title_short Promising alternative therapeutics for oral candidiasis
title_full Promising alternative therapeutics for oral candidiasis
title_fullStr Promising alternative therapeutics for oral candidiasis
title_full_unstemmed Promising alternative therapeutics for oral candidiasis
title_sort Promising alternative therapeutics for oral candidiasis
author Rodrigues, Célia F.
author_facet Rodrigues, Célia F.
Rodrigues, M. Elisa
Henriques, Mariana
author_role author
author2 Rodrigues, M. Elisa
Henriques, Mariana
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rodrigues, Célia F.
Rodrigues, M. Elisa
Henriques, Mariana
dc.subject.por.fl_str_mv Candida
oral candidiasis
resistance
antifungal treatment
plants
honey
probiotics
photodynamic therapy
Science & Technology
topic Candida
oral candidiasis
resistance
antifungal treatment
plants
honey
probiotics
photodynamic therapy
Science & Technology
description Candida is the main human fungal pathogen causing infections (candidiasis), mostly in the elderly and immunocompromised hosts. Even though Candida spp. is a member of the oral microbiota in symbiosis, in some circumstances, it can cause microbial imbalance leading to dysbiosis, resulting in oral diseases. Alternative therapies are urgently needed to treat oral candidiasis (usually associated to biofilms), as several antifungal drugs activity has been compromised. This has occurred especially due to an increasing occurrence of drugresistant in Candida spp. strains. The overuse of antifungal medications, systemic toxicity, cross-reactivity with other drugs and a presently low number of drug molecules with antifungal activity, have contributed to important clinical limitations. We undertook a structured search of bibliographic databases (PubMed Central, Elseviers ScienceDirect, SCOPUS and Springers SpringerLink) for peer-reviewed research literature using a focused review in the areas of alternatives to manage oral candidiasis. The keywords used were candidiasis, oral candidiasis, biofilm + candida, alternative treatment, combination therapy + candida and the reports from the last 10 to 15 years were considered for this review. This review identified several promising new approaches in the treatment of oral candidiasis: combination anti-Candida therapies, denture cleansers, mouth rinses as alternatives for disrupting candidal biofilms, natural compounds (e.g. honey, probiotics, plant extracts and essential oils) and photodynamic therapy. The findings of this review confirm the importance and the urgency of the development of efficacious therapies for oral candidal infections
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/61266
url http://hdl.handle.net/1822/61266
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues, Célia F.; Rodrigues, M. Elisa; Henriques, Mariana, Promising alternative therapeutics for oral candidiasis. Current Medicinal Chemistry, 26(14), 2515-2528, 2019
09298673
1875533X
10.2174/0929867325666180601102333
29852856
http://benthamscience.com/journals/current-medicinal-chemistry/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
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