Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes

Detalhes bibliográficos
Autor(a) principal: Gameiro, Andreia
Data de Publicação: 2021
Outros Autores: Nascimento, Catarina, Urbano, Ana Catarina, Correia, Jorge Manuel de Jesus, Ferreira, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/23407
Resumo: Research Areas: Veterinary Sciences
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spelling Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypesFeline mammary carcinomaLeptinLeptin receptorFree leptin indexBiomarkersResearch Areas: Veterinary SciencesABSTRACT - Obesity is an established risk factor for breast cancer in post-menopausal women, being associated with elevated serum levels of leptin. Although overweight is a common condition in cat, the role of leptin and its receptor in feline mammary carcinoma remains unsettled. In this study, serum leptin and leptin receptor (ObR) levels were investigated in 58 cats with mammary carcinoma and compared with those of healthy animals, as were the expression levels of leptin and ObR in tumor tissues. The results showed that the Free Leptin Index is significantly decreased in cats with mammary carcinoma (p = 0.0006), particularly in those with luminal B and HER2-positive tumors, and that these animals also present significantly lower serum leptin levels (p < 0.0001 and p < 0.005, respectively). Interestingly, ulcerating tumors (p = 0.0005) and shorter disease-free survival (p = 0.0217) were associated to serum leptin levels above 4.17 pg/mL. In contrast, elevated serum ObR levels were found in all cats with mammary carcinoma (p < 0.0001), with levels above 16.89 ng/mL being associated with smaller tumors (p = 0.0118), estrogen receptor negative status (p = 0.0291) and increased serum levels of CTLA-4 (p = 0.0056), TNF-alpha (p = 0.0025), PD-1 (p = 0.0023), and PD-L1 (p = 0.0002). In tumor samples, leptin is overexpressed in luminal B and triple-negative carcinomas (p = 0.0046), whereas ObR is found to be overexpressed in luminal B tumors (p = 0.0425). Altogether, our results support the hypothesis that serum levels of leptin and ObR can be used as biomarkers of specific feline mammary carcinoma subtypes, and suggests the use of leptin antagonists as a therapeutic tool, reinforcing the utility of the cat as a cancer model.Frontiers Media SARepositório da Universidade de LisboaGameiro, AndreiaNascimento, CatarinaUrbano, Ana CatarinaCorreia, Jorge Manuel de JesusFerreira, Fernando2022-02-06T00:34:14Z2021-02-102021-02-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/23407engGameiro A, Nascimento C, Urbano AC, Correia J, Ferreira F. 2021. Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes. Frontiers in Veterinary Science, 8:625147. Doi: 10.3389/fvets.2021.62514710.3389/fvets.2021.6251472297-1769info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:52:58ZPortal AgregadorONG
dc.title.none.fl_str_mv Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes
title Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes
spellingShingle Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes
Gameiro, Andreia
Feline mammary carcinoma
Leptin
Leptin receptor
Free leptin index
Biomarkers
title_short Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes
title_full Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes
title_fullStr Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes
title_full_unstemmed Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes
title_sort Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes
author Gameiro, Andreia
author_facet Gameiro, Andreia
Nascimento, Catarina
Urbano, Ana Catarina
Correia, Jorge Manuel de Jesus
Ferreira, Fernando
author_role author
author2 Nascimento, Catarina
Urbano, Ana Catarina
Correia, Jorge Manuel de Jesus
Ferreira, Fernando
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gameiro, Andreia
Nascimento, Catarina
Urbano, Ana Catarina
Correia, Jorge Manuel de Jesus
Ferreira, Fernando
dc.subject.por.fl_str_mv Feline mammary carcinoma
Leptin
Leptin receptor
Free leptin index
Biomarkers
topic Feline mammary carcinoma
Leptin
Leptin receptor
Free leptin index
Biomarkers
description Research Areas: Veterinary Sciences
publishDate 2021
dc.date.none.fl_str_mv 2021-02-10
2021-02-10T00:00:00Z
2022-02-06T00:34:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/23407
url http://hdl.handle.net/10400.5/23407
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gameiro A, Nascimento C, Urbano AC, Correia J, Ferreira F. 2021. Serum and tissue expression levels of leptin and leptin receptor are putative markers of specific feline mammary carcinoma subtypes. Frontiers in Veterinary Science, 8:625147. Doi: 10.3389/fvets.2021.625147
10.3389/fvets.2021.625147
2297-1769
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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