Improved cardiac and venous pressures during hospital stay in patients with acute heart failure : an echocardiography and biomarkers study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/42895 |
Resumo: | © 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-Non Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| id |
RCAP_74ba42e42a8297f5a8a773a964e0c12f |
|---|---|
| oai_identifier_str |
oai:repositorio.ul.pt:10451/42895 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Improved cardiac and venous pressures during hospital stay in patients with acute heart failure : an echocardiography and biomarkers studyAcute heart failureCongestionBiomarkerEchocardiographyHeart failure with preserved ejection fractionHeart failure with reduced ejection fraction© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-Non Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.Aims: Changes in echocardiographic parameters and biomarkers of cardiac and venous pressures or estimated plasma volume during hospitalization associated with decongestive treatments in acute heart failure (AHF) patients with either preserved left ventricular ejection fraction (LVEF) (HFPEF) or reduced LVEF (HFREF) are poorly assessed. Methods and results: From the metabolic road to diastolic heart failure: diastolic heart failure (MEDIA‐DHF) study, 111 patients were included in this substudy: 77 AHF (43 HFPEF and 34 HFREF) and 34 non‐cardiac dyspnea patients. Echocardiographic measurements and blood samples were obtained within 4 h of presentation at the emergency department and before hospital discharge. In AHF patients, echocardiographic indices of cardiac and venous pressures, including inferior vena cava diameter [from 22 (16–24) mm to 13 (11–18) mm, P = 0.009], its respiratory variability [from 32 (8–44) % to 43 (29–70) %, P = 0.04], medial E/e' [from 21.1 (15.8–29.6) to 16.6 (11.7–24.3), P = 0.004], and E wave deceleration time [from 129 (105–156) ms to 166 (128–203) ms, P = 0.003], improved during hospitalization, similarly in HFPEF and HFREF patients. By contrast, no changes were seen in non‐cardiac dyspnea patients. In AHF patients, all plasma biomarkers of cardiac and venous pressures, namely B‐type natriuretic peptide [from 935 (514–2037) pg/mL to 308 (183–609) pg/mL, P < 0.001], mid‐regional pro‐atrial natriuretic peptide [from 449 (274–653) pmol/L to 366 (242–549) pmol/L, P < 0.001], and soluble CD‐146 levels [from 528 (406–654) ng/mL to 450 (374–529) ng/mL, P = 0.003], significantly decreased during hospitalization, similarly in HFPEF and HFREF patients. Echocardiographic parameters of cardiac chamber dimensions [left ventricular end‐diastolic volume: from 120 (76–140) mL to 118 (95–176) mL, P = 0.23] and cardiac index [from 2.1 (1.6–2.6) mL/min/m2 to 1.9 (1.4–2.4) mL/min/m2, P = 0.55] were unchanged in AHF patients, except tricuspid annular plane systolic excursion (TAPSE) that improved during hospitalization [from 16 (15–19) mm to 19 (17–21) mm, P = 0.04]. Estimated plasma volume increased in both AHF [from 4.8 (4.2–5.6) to 5.1 (4.4–5.8), P = 0.03] and non‐cardiac dyspnea patients (P = 0.01). Serum creatinine [from 1.18 (0.90–1.53) to 1.19 (0.86–1.70) mg/dL, P = 0.89] and creatinine‐based estimated glomerular filtration rate [from 59 (40–75) mL/min/1.73m2 to 56 (38–73) mL/min/1.73m2, P = 0.09] were similar, while plasma cystatin C [from 1.50 (1.20–2.27) mg/L to 1.78 (1.33–2.59) mg/L, P < 0.001] and neutrophil gelatinase associated lipocalin (NGAL) [from 127 (95–260) ng/mL to 167 (104–263) ng/mL, P = 0.004] increased during hospitalization in AHF. Conclusions: Echocardiographic parameters and plasma biomarkers of cardiac and venous pressures improved during AHF hospitalization in both acute HFPEF and HFREF patients, while cardiac chamber dimensions, cardiac output, and estimated plasma volume showed minimal changes.This study was supported by a grant from the European Union funded by the Seventh Framework Programme for Health in 2010 (FP7-HEALTH-2010-MEDIA; Luxembourg) (F.Z., P.R., A. M) and research fellowship from Japan Heart Foundation (E. A.). P.R., N.G., T.C., and F.Z. are supported by a public grant overseen by the French National Research Agency (ANR) as part of the second “Investissements d’Avenir” programmes Fighting Heart Failure (reference: ANR-15-RHU-0004), GEENAGE Impact Lorraine Université d’Excellence and by the Contrat de Plan Etat Lorraine IT2MP and FEDER Lorraine. LNLVA is supported by a training grant from the European Society of Cardiology (2015) and a travelling award from the International Society for Heart and Lung Transplantation (August 2015 and 2016). LNLVA gratefully acknowledges the financial support from the Fund for Cardiac Surgery through the Jacqueline Bernheim prize 2015.John Wiley and SonsRepositório da Universidade de LisboaAkiyama, EiichiCinotti, RaphaëlČerlinskaitė, KamilėVan Aelst, Lucas N. L.Arrigo, MattiaPlácido, RuiChouihed, TaharGirerd, NicolasZannad, FaiezRossignol, PatrickBadoz, MarcLaunay, Jean-MarieGayat, EtienneCohen-Solal, AlainLam, Carolyn S. P.Testani, JeffreyMullens, WilfriedCotter, GadSeronde, Marie-FranceMebazaa, Alexandre2020-04-16T13:02:41Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/42895engESC Heart Failure (2020)10.1002/ehf2.126452055-5822info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:43:04Zoai:repositorio.ul.pt:10451/42895Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:55:49.518072Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Improved cardiac and venous pressures during hospital stay in patients with acute heart failure : an echocardiography and biomarkers study |
| title |
Improved cardiac and venous pressures during hospital stay in patients with acute heart failure : an echocardiography and biomarkers study |
| spellingShingle |
Improved cardiac and venous pressures during hospital stay in patients with acute heart failure : an echocardiography and biomarkers study Akiyama, Eiichi Acute heart failure Congestion Biomarker Echocardiography Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction |
| title_short |
Improved cardiac and venous pressures during hospital stay in patients with acute heart failure : an echocardiography and biomarkers study |
| title_full |
Improved cardiac and venous pressures during hospital stay in patients with acute heart failure : an echocardiography and biomarkers study |
| title_fullStr |
Improved cardiac and venous pressures during hospital stay in patients with acute heart failure : an echocardiography and biomarkers study |
| title_full_unstemmed |
Improved cardiac and venous pressures during hospital stay in patients with acute heart failure : an echocardiography and biomarkers study |
| title_sort |
Improved cardiac and venous pressures during hospital stay in patients with acute heart failure : an echocardiography and biomarkers study |
| author |
Akiyama, Eiichi |
| author_facet |
Akiyama, Eiichi Cinotti, Raphaël Čerlinskaitė, Kamilė Van Aelst, Lucas N. L. Arrigo, Mattia Plácido, Rui Chouihed, Tahar Girerd, Nicolas Zannad, Faiez Rossignol, Patrick Badoz, Marc Launay, Jean-Marie Gayat, Etienne Cohen-Solal, Alain Lam, Carolyn S. P. Testani, Jeffrey Mullens, Wilfried Cotter, Gad Seronde, Marie-France Mebazaa, Alexandre |
| author_role |
author |
| author2 |
Cinotti, Raphaël Čerlinskaitė, Kamilė Van Aelst, Lucas N. L. Arrigo, Mattia Plácido, Rui Chouihed, Tahar Girerd, Nicolas Zannad, Faiez Rossignol, Patrick Badoz, Marc Launay, Jean-Marie Gayat, Etienne Cohen-Solal, Alain Lam, Carolyn S. P. Testani, Jeffrey Mullens, Wilfried Cotter, Gad Seronde, Marie-France Mebazaa, Alexandre |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Akiyama, Eiichi Cinotti, Raphaël Čerlinskaitė, Kamilė Van Aelst, Lucas N. L. Arrigo, Mattia Plácido, Rui Chouihed, Tahar Girerd, Nicolas Zannad, Faiez Rossignol, Patrick Badoz, Marc Launay, Jean-Marie Gayat, Etienne Cohen-Solal, Alain Lam, Carolyn S. P. Testani, Jeffrey Mullens, Wilfried Cotter, Gad Seronde, Marie-France Mebazaa, Alexandre |
| dc.subject.por.fl_str_mv |
Acute heart failure Congestion Biomarker Echocardiography Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction |
| topic |
Acute heart failure Congestion Biomarker Echocardiography Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction |
| description |
© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-Non Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-04-16T13:02:41Z 2020 2020-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/42895 |
| url |
http://hdl.handle.net/10451/42895 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
ESC Heart Failure (2020) 10.1002/ehf2.12645 2055-5822 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
John Wiley and Sons |
| publisher.none.fl_str_mv |
John Wiley and Sons |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799134499481583616 |