Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generation
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/20466 |
Resumo: | The present study describes the first example of hybrid particles composed of amorphous silica and corrole. The hybrid particles were obtained by covalent linking of the gallium(III)(pyridine) complex of 5,10,15-tris(pentafluorophenyl) corrole (GaPFC) at the surface of functionalized silica spheres. The functionalization step was achieved by a nucleophilic substitution reaction between corrole and 3-aminopropyltriethoxysilane previously grafted at the silica surfaces. The hybrids were morphologically and chemically characterized and the results have confirmed covalent linkages between corrole molecules and the silica particles. Preliminary studies on the capacity of corrole and hybrid particles to generate singlet oxygen was evaluated by a chemical method in which 1,3-diphenylisobenzofuran was used to trap singlet oxygen. The new corrole-silica hybrid particles have shown lower efficiency to generate singlet oxygen as compared to the pure corrole precursor. This effect was interpreted as a consequence of interparticle interactions mediated by the corrole molecules grafted at the silica surfaces that result in their clustering. Taken together, these findings demonstrate that despite lower efficiency in terms of singlet oxygen generation, the hybrid materials offer an alternative route to develop new platforms with potential for photodynamic therapy. |
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Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generationRAY PHOTOELECTRON-SPECTROSCOPYPHOTODYNAMIC THERAPYNANOPARTICLESPORPHYRINSSURFACEFILMSThe present study describes the first example of hybrid particles composed of amorphous silica and corrole. The hybrid particles were obtained by covalent linking of the gallium(III)(pyridine) complex of 5,10,15-tris(pentafluorophenyl) corrole (GaPFC) at the surface of functionalized silica spheres. The functionalization step was achieved by a nucleophilic substitution reaction between corrole and 3-aminopropyltriethoxysilane previously grafted at the silica surfaces. The hybrids were morphologically and chemically characterized and the results have confirmed covalent linkages between corrole molecules and the silica particles. Preliminary studies on the capacity of corrole and hybrid particles to generate singlet oxygen was evaluated by a chemical method in which 1,3-diphenylisobenzofuran was used to trap singlet oxygen. The new corrole-silica hybrid particles have shown lower efficiency to generate singlet oxygen as compared to the pure corrole precursor. This effect was interpreted as a consequence of interparticle interactions mediated by the corrole molecules grafted at the silica surfaces that result in their clustering. Taken together, these findings demonstrate that despite lower efficiency in terms of singlet oxygen generation, the hybrid materials offer an alternative route to develop new platforms with potential for photodynamic therapy.ROYAL SOC CHEMISTRY2017-12-07T19:48:02Z2013-01-01T00:00:00Z2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/20466eng2046-206910.1039/c2ra22133kBarata, Joana F. B.Daniel-da-Silva, Ana L.Neves, M. Graca P. M. S.Cavaleiro, Jose A. S.Trindade, Titoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:40:11Zoai:ria.ua.pt:10773/20466Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:55:09.478834Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generation |
title |
Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generation |
spellingShingle |
Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generation Barata, Joana F. B. RAY PHOTOELECTRON-SPECTROSCOPY PHOTODYNAMIC THERAPY NANOPARTICLES PORPHYRINS SURFACE FILMS |
title_short |
Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generation |
title_full |
Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generation |
title_fullStr |
Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generation |
title_full_unstemmed |
Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generation |
title_sort |
Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generation |
author |
Barata, Joana F. B. |
author_facet |
Barata, Joana F. B. Daniel-da-Silva, Ana L. Neves, M. Graca P. M. S. Cavaleiro, Jose A. S. Trindade, Tito |
author_role |
author |
author2 |
Daniel-da-Silva, Ana L. Neves, M. Graca P. M. S. Cavaleiro, Jose A. S. Trindade, Tito |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Barata, Joana F. B. Daniel-da-Silva, Ana L. Neves, M. Graca P. M. S. Cavaleiro, Jose A. S. Trindade, Tito |
dc.subject.por.fl_str_mv |
RAY PHOTOELECTRON-SPECTROSCOPY PHOTODYNAMIC THERAPY NANOPARTICLES PORPHYRINS SURFACE FILMS |
topic |
RAY PHOTOELECTRON-SPECTROSCOPY PHOTODYNAMIC THERAPY NANOPARTICLES PORPHYRINS SURFACE FILMS |
description |
The present study describes the first example of hybrid particles composed of amorphous silica and corrole. The hybrid particles were obtained by covalent linking of the gallium(III)(pyridine) complex of 5,10,15-tris(pentafluorophenyl) corrole (GaPFC) at the surface of functionalized silica spheres. The functionalization step was achieved by a nucleophilic substitution reaction between corrole and 3-aminopropyltriethoxysilane previously grafted at the silica surfaces. The hybrids were morphologically and chemically characterized and the results have confirmed covalent linkages between corrole molecules and the silica particles. Preliminary studies on the capacity of corrole and hybrid particles to generate singlet oxygen was evaluated by a chemical method in which 1,3-diphenylisobenzofuran was used to trap singlet oxygen. The new corrole-silica hybrid particles have shown lower efficiency to generate singlet oxygen as compared to the pure corrole precursor. This effect was interpreted as a consequence of interparticle interactions mediated by the corrole molecules grafted at the silica surfaces that result in their clustering. Taken together, these findings demonstrate that despite lower efficiency in terms of singlet oxygen generation, the hybrid materials offer an alternative route to develop new platforms with potential for photodynamic therapy. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01T00:00:00Z 2013 2017-12-07T19:48:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/20466 |
url |
http://hdl.handle.net/10773/20466 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2046-2069 10.1039/c2ra22133k |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
ROYAL SOC CHEMISTRY |
publisher.none.fl_str_mv |
ROYAL SOC CHEMISTRY |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799137604596137984 |