Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets

Detalhes bibliográficos
Autor(a) principal: Costa, Ana Sofia Henriques da
Data de Publicação: 2013
Outros Autores: Pires, Virgínia Maria Rico, Fontes, Carlos Mendes Godinho Andrade, Prates, José António Mestre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/7106
Resumo: Articles in International Journals
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spelling Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage dietsBeef cattleAdipose tissueMuscleGene expressionFat depositionArticles in International JournalsBackground: Both genetic background and finishing system can alter fat deposition, thus indicating their influence on adipogenic and lipogenic factors. However, the molecular mechanisms underlying fat deposition and fatty acid composition in beef cattle are not fully understood. This study aimed to assess the effect of breed and dietary silage level on the expression patterns of key genes controlling lipid metabolism in subcutaneous adipose tissue (SAT) and longissimus lumborum (LL) muscle of cattle. To that purpose, forty bulls from two genetically diverse Portuguese bovine breeds with distinct maturity rates, Alentejana and Barrosã, were selected and fed either low (30% maize silage/70% concentrate) or high silage (70% maize silage/30% concentrate) diets. Results: The results suggested that enhanced deposition of fatty acids in the SAT from Barrosã bulls, when compared to Alentejana, could be due to higher expression levels of lipogenesis (SCD and LPL) and β-oxidation (CRAT) related genes. Our results also indicated that SREBF1 expression in the SAT is increased by feeding the low silage diet. Together, these results point out to a higher lipid turnover in the SAT of Barrosã bulls when compared to Alentejana. In turn, lipid deposition in the LL muscle is related to the expression of adipogenic (PPARG and FABP4) and lipogenic (ACACA and SCD) genes. The positive correlation between ACACA expression levels and total lipids, as well trans fatty acids, points to ACACA as a major player in intramuscular deposition in ruminants. Moreover, results reinforce the role of FABP4 in intramuscular fat development and the SAT as the major site for lipid metabolism in ruminants. Conclusions: Overall, the results showed that SAT and LL muscle fatty acid composition are mostly dependent on the genetic background. In addition, dietary silage level impacted on muscle lipid metabolism to a greater extent than on that of SAT, as evaluated by gene expression levels of adipogenic and lipogenic factors. Moreover, the response to diet composition evaluated through mRNA levels and fatty acid composition showed interesting differences between Alentejana and Barrosã bulls. These findings provide evidence that the genetic background should be taken into account while devising diet-based strategies to manipulate fatty acid composition of beef cattle tissues.BioMed CentralRepositório da Universidade de LisboaCosta, Ana Sofia Henriques daPires, Virgínia Maria RicoFontes, Carlos Mendes Godinho AndradePrates, José António Mestre2014-09-09T09:18:54Z2013-06-172013-06-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/7106engCOSTA, A.S.H., et al. (2013). Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets. BMC Veterinary Research, 9(118), 1-16. doi: 10.1186/1746-6148-9-1181746-614810.1186/1746-6148-9-118info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:37:52Zoai:www.repository.utl.pt:10400.5/7106Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:54:19.558524Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets
title Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets
spellingShingle Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets
Costa, Ana Sofia Henriques da
Beef cattle
Adipose tissue
Muscle
Gene expression
Fat deposition
title_short Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets
title_full Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets
title_fullStr Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets
title_full_unstemmed Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets
title_sort Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets
author Costa, Ana Sofia Henriques da
author_facet Costa, Ana Sofia Henriques da
Pires, Virgínia Maria Rico
Fontes, Carlos Mendes Godinho Andrade
Prates, José António Mestre
author_role author
author2 Pires, Virgínia Maria Rico
Fontes, Carlos Mendes Godinho Andrade
Prates, José António Mestre
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Costa, Ana Sofia Henriques da
Pires, Virgínia Maria Rico
Fontes, Carlos Mendes Godinho Andrade
Prates, José António Mestre
dc.subject.por.fl_str_mv Beef cattle
Adipose tissue
Muscle
Gene expression
Fat deposition
topic Beef cattle
Adipose tissue
Muscle
Gene expression
Fat deposition
description Articles in International Journals
publishDate 2013
dc.date.none.fl_str_mv 2013-06-17
2013-06-17T00:00:00Z
2014-09-09T09:18:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/7106
url http://hdl.handle.net/10400.5/7106
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv COSTA, A.S.H., et al. (2013). Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets. BMC Veterinary Research, 9(118), 1-16. doi: 10.1186/1746-6148-9-118
1746-6148
10.1186/1746-6148-9-118
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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