Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study

Detalhes bibliográficos
Autor(a) principal: van der Ende, Emma L.
Data de Publicação: 2022
Outros Autores: Heller, Carolin, Sogorb-Esteve, Aitana, Swift, Imogen J., McFall, David, Peakman, Georgia, Bouzigues, Arabella, Poos, Jackie M., Jiskoot, Lize C., Panman, Jessica L., Papma, Janne M., Bargalló, Nuria, Rohrer, Jonathan D., Seelaar, Harro, Afonso, Sónia, Almeida, Maria Rosario, Anderl-Straub, Sarah, Andersson, Christin, Antonell, Anna, Archetti, Silvana, Bartha, Robart, Indakoetxea, Begoña, Bender, Benjamin, Benussi, Alberto, Benussi, Luisa, Bessi, Valentina, Binetti, Giuliano, Mead, Simon, Black, Sandra, Borrego-Ecija, Sergi, Bras, Jose, Bruffaerts, Rose, Mitchell, Sara, Cañada, Marta, Cantoni, Valentina, Caroppo, Paola, Castelo-Branco, Miguel, Convery, Rhian, Miltenberger-Miltenyi, Gabriel, Cope, Thomas, Di Fede, Giuseppe, Díez, Alina, Duro, Diana, Jelic, Vesna, Fenoglio, Chiara, Ferrari, Camilla, Ferreira, Catarina B., Fox, Nick, Freedman, Morris, Fumagalli, Giorgio, van Minkelen, Rick, Gabilondo, Alazne, Gasparotti, Roberto, Gauthier, Serge, Karnath, Hans-Otto, Gazzina, Stefano, Giaccone, Giorgio, Gorostidi, Ana, Greaves, Caroline, Guerreiro, Rita, Hoegen, Tobias, Keren, Ron, Langheinrich, Tobias, Leitão, Maria João, Lladó, Albert, Lombardi, Gemma, Loosli, Sandra, Tiraboschi, Pietro, Maruta, Carolina, Moore, Katrina, Nacmias, Benedetta, Nicholas, Jennifer, Öijerstedt, Linn, Olives, Jaume, Ourselin, Sebastien, Meeter, Lieke H., Padovani, Alessandro, Pievani, Michela, Todd, Emily, Polito, Cristina, Premi, Enrico, Prioni, Sara, Prix, Catharina, Rademakers, Rosa, Redaelli, Veronica, Rittman, Tim, Dopper, Elise G. P., Rogaeva, Ekaterina, Rosa-Neto, Pedro, Rossi, Giacomina, Rosser, Martin, Santiago, Beatriz, Scarpini, Elio, Schönecker, Sonja, Semler, Elisa, Shafei, Rachelle, Shoesmith, Christen, Bocchetta, Martina, Tábuas-Pereira, Miguel, Van Damme, Philip, Tainta, Mikel, Taipa, Ricardo, Tang-Wai, David, Thomas, David L., Thompson, Paul, Thonberg, Hakan, Timberlake, Carolyn, Vandenbulcke, Mathieu, Veldsman, Michele, Verdelho, Ana, Villanua, Jorge, Warren, Jason, Wilke, Carlo, Arighi, Andrea, Woollacott, Ione, Wlasich, Elisabeth, Zulaica, Miren, Cash, David, Graff, Caroline, Synofzik, Matthis, Moreno, Fermin, Finger, Elizabeth, Sanchez-Valle, Raquel, Vandenberghe, Rik, Balasa, Mircea, Laforce, Robert, Masellis, Mario, Tartaglia, Maria Carmela, Rowe, James B., Butler, Chris, Ducharme, Simon, Gerhard, Alexander, Danek, Adrian, Levin, Johannes, Pijnenburg, Yolande A. L., Barandiaran, Myriam, Otto, Markus, Borroni, Barbara, Tagliavini, Fabrizio, De Mendonça, Alexandre, Santana, Isabel, Galimberti, Daniela, Sorbi, Sandro, Zetterberg, Henrik, Huang, Eric, van Swieten, John C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54421
Resumo: © The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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spelling Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI studyBiomarkerComplementFrontotemporal dementiaNeuroinflammation© The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Background: Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity, as biomarkers in cerebrospinal fluid (CSF) and plasma of presymptomatic and symptomatic genetic FTD mutation carriers. Methods: We measured the complement proteins C1q and C3b in CSF by ELISAs in 224 presymptomatic and symptomatic GRN, C9orf72 or MAPT mutation carriers and non-carriers participating in the Genetic Frontotemporal Dementia Initiative (GENFI), a multicentre cohort study. Next, we used multiplex immunoassays to measure a panel of 14 complement proteins in plasma of 431 GENFI participants. We correlated complement protein levels with corresponding clinical and neuroimaging data, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP). Results: CSF C1q and C3b, as well as plasma C2 and C3, were elevated in symptomatic mutation carriers compared to presymptomatic carriers and non-carriers. In genetic subgroup analyses, these differences remained statistically significant for C9orf72 mutation carriers. In presymptomatic carriers, several complement proteins correlated negatively with grey matter volume of FTD-related regions and positively with NfL and GFAP. In symptomatic carriers, correlations were additionally observed with disease duration and with Mini Mental State Examination and Clinical Dementia Rating scale® plus NACC Frontotemporal lobar degeneration sum of boxes scores. Conclusions: Elevated levels of CSF C1q and C3b, as well as plasma C2 and C3, demonstrate the presence of complement activation in the symptomatic stage of genetic FTD. Intriguingly, correlations with several disease measures in presymptomatic carriers suggest that complement protein levels might increase before symptom onset. Although the overlap between groups precludes their use as diagnostic markers, further research is needed to determine their potential to monitor dysregulation of the complement system in FTD.This study was supported in the Netherlands by Memorabel grants from Deltaplan Dementie (ZonMw and Alzheimer Nederland; grant numbers 733050813, 733050103, 733050513), the Bluefield Project to Cure Frontotemporal Dementia, the Dioraphte foundation (grant number 1402 1300), and the European Joint Programme—Neurodegenerative Disease Research and the Netherlands Organisation for Health Research and Development (PreFrontALS: 733051042, RiMod-FTD: 733051024); in Belgium by the Mady Browaeys Fonds voor Onderzoek naar Frontotemporale Degeneratie; in the UK by the MRC UK GENFI grant (MR/M023664/1) and the JPND GENFI-PROX grant (2019-02248); JDR is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH); ASE supported by the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK; IJS is supported by the Alzheimer’s Association; JBR is supported by the Wellcome Trust (103838); in Spain by the Fundació Marató de TV3 (20143810 to RSV); in Germany by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy—ID 390857198) and by grant 779357 “Solve-RD” from the Horizon 2020 Research and Innovation Programme (to MS); in Sweden by grants from the Swedish FTD Initiative funded by the Schörling Foundation, grants from JPND PreFrontALS Swedish Research Council (VR) 529–2014-7504, Swedish Research Council (VR) 2015–02926, Swedish Research Council (VR) 2018–02754, Swedish Brain Foundation, Swedish Alzheimer Foundation, Stockholm County Council ALF, Swedish Demensfonden, Stohnes foundation, Gamla Tjänarinnor, Karolinska Institutet Doctoral Funding, and StratNeuro. HZ is a Wallenberg Scholar.Springer NatureRepositório da Universidade de Lisboavan der Ende, Emma L.Heller, CarolinSogorb-Esteve, AitanaSwift, Imogen J.McFall, DavidPeakman, GeorgiaBouzigues, ArabellaPoos, Jackie M.Jiskoot, Lize C.Panman, Jessica L.Papma, Janne M.Bargalló, NuriaRohrer, Jonathan D.Seelaar, HarroAfonso, SóniaAlmeida, Maria RosarioAnderl-Straub, SarahAndersson, ChristinAntonell, AnnaArchetti, SilvanaBartha, RobartIndakoetxea, BegoñaBender, BenjaminBenussi, AlbertoBenussi, LuisaBessi, ValentinaBinetti, GiulianoMead, SimonBlack, SandraBorrego-Ecija, SergiBras, JoseBruffaerts, RoseMitchell, SaraCañada, MartaCantoni, ValentinaCaroppo, PaolaCastelo-Branco, MiguelConvery, RhianMiltenberger-Miltenyi, GabrielCope, ThomasDi Fede, GiuseppeDíez, AlinaDuro, DianaJelic, VesnaFenoglio, ChiaraFerrari, CamillaFerreira, Catarina B.Fox, NickFreedman, MorrisFumagalli, Giorgiovan Minkelen, RickGabilondo, AlazneGasparotti, RobertoGauthier, SergeKarnath, Hans-OttoGazzina, StefanoGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHoegen, TobiasKeren, RonLangheinrich, TobiasLeitão, Maria JoãoLladó, AlbertLombardi, GemmaLoosli, SandraTiraboschi, PietroMaruta, CarolinaMoore, KatrinaNacmias, BenedettaNicholas, JenniferÖijerstedt, LinnOlives, JaumeOurselin, SebastienMeeter, Lieke H.Padovani, AlessandroPievani, MichelaTodd, EmilyPolito, CristinaPremi, EnricoPrioni, SaraPrix, CatharinaRademakers, RosaRedaelli, VeronicaRittman, TimDopper, Elise G. P.Rogaeva, EkaterinaRosa-Neto, PedroRossi, GiacominaRosser, MartinSantiago, BeatrizScarpini, ElioSchönecker, SonjaSemler, ElisaShafei, RachelleShoesmith, ChristenBocchetta, MartinaTábuas-Pereira, MiguelVan Damme, PhilipTainta, MikelTaipa, RicardoTang-Wai, DavidThomas, David L.Thompson, PaulThonberg, HakanTimberlake, CarolynVandenbulcke, MathieuVeldsman, MicheleVerdelho, AnaVillanua, JorgeWarren, JasonWilke, CarloArighi, AndreaWoollacott, IoneWlasich, ElisabethZulaica, MirenCash, DavidGraff, CarolineSynofzik, MatthisMoreno, FerminFinger, ElizabethSanchez-Valle, RaquelVandenberghe, RikBalasa, MirceaLaforce, RobertMasellis, MarioTartaglia, Maria CarmelaRowe, James B.Butler, ChrisDucharme, SimonGerhard, AlexanderDanek, AdrianLevin, JohannesPijnenburg, Yolande A. L.Barandiaran, MyriamOtto, MarkusBorroni, BarbaraTagliavini, FabrizioDe Mendonça, AlexandreSantana, IsabelGalimberti, DanielaSorbi, SandroZetterberg, HenrikHuang, Ericvan Swieten, John C.2022-09-09T14:42:57Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54421eng10.1186/s12974-022-02573-01742-2094info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:00:45Zoai:repositorio.ul.pt:10451/54421Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:13.911929Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
title Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
spellingShingle Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
van der Ende, Emma L.
Biomarker
Complement
Frontotemporal dementia
Neuroinflammation
title_short Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
title_full Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
title_fullStr Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
title_full_unstemmed Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
title_sort Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
author van der Ende, Emma L.
author_facet van der Ende, Emma L.
Heller, Carolin
Sogorb-Esteve, Aitana
Swift, Imogen J.
McFall, David
Peakman, Georgia
Bouzigues, Arabella
Poos, Jackie M.
Jiskoot, Lize C.
Panman, Jessica L.
Papma, Janne M.
Bargalló, Nuria
Rohrer, Jonathan D.
Seelaar, Harro
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Archetti, Silvana
Bartha, Robart
Indakoetxea, Begoña
Bender, Benjamin
Benussi, Alberto
Benussi, Luisa
Bessi, Valentina
Binetti, Giuliano
Mead, Simon
Black, Sandra
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Mitchell, Sara
Cañada, Marta
Cantoni, Valentina
Caroppo, Paola
Castelo-Branco, Miguel
Convery, Rhian
Miltenberger-Miltenyi, Gabriel
Cope, Thomas
Di Fede, Giuseppe
Díez, Alina
Duro, Diana
Jelic, Vesna
Fenoglio, Chiara
Ferrari, Camilla
Ferreira, Catarina B.
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
van Minkelen, Rick
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Karnath, Hans-Otto
Gazzina, Stefano
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Hoegen, Tobias
Keren, Ron
Langheinrich, Tobias
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Tiraboschi, Pietro
Maruta, Carolina
Moore, Katrina
Nacmias, Benedetta
Nicholas, Jennifer
Öijerstedt, Linn
Olives, Jaume
Ourselin, Sebastien
Meeter, Lieke H.
Padovani, Alessandro
Pievani, Michela
Todd, Emily
Polito, Cristina
Premi, Enrico
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rittman, Tim
Dopper, Elise G. P.
Rogaeva, Ekaterina
Rosa-Neto, Pedro
Rossi, Giacomina
Rosser, Martin
Santiago, Beatriz
Scarpini, Elio
Schönecker, Sonja
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Bocchetta, Martina
Tábuas-Pereira, Miguel
Van Damme, Philip
Tainta, Mikel
Taipa, Ricardo
Tang-Wai, David
Thomas, David L.
Thompson, Paul
Thonberg, Hakan
Timberlake, Carolyn
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Arighi, Andrea
Woollacott, Ione
Wlasich, Elisabeth
Zulaica, Miren
Cash, David
Graff, Caroline
Synofzik, Matthis
Moreno, Fermin
Finger, Elizabeth
Sanchez-Valle, Raquel
Vandenberghe, Rik
Balasa, Mircea
Laforce, Robert
Masellis, Mario
Tartaglia, Maria Carmela
Rowe, James B.
Butler, Chris
Ducharme, Simon
Gerhard, Alexander
Danek, Adrian
Levin, Johannes
Pijnenburg, Yolande A. L.
Barandiaran, Myriam
Otto, Markus
Borroni, Barbara
Tagliavini, Fabrizio
De Mendonça, Alexandre
Santana, Isabel
Galimberti, Daniela
Sorbi, Sandro
Zetterberg, Henrik
Huang, Eric
van Swieten, John C.
author_role author
author2 Heller, Carolin
Sogorb-Esteve, Aitana
Swift, Imogen J.
McFall, David
Peakman, Georgia
Bouzigues, Arabella
Poos, Jackie M.
Jiskoot, Lize C.
Panman, Jessica L.
Papma, Janne M.
Bargalló, Nuria
Rohrer, Jonathan D.
Seelaar, Harro
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Archetti, Silvana
Bartha, Robart
Indakoetxea, Begoña
Bender, Benjamin
Benussi, Alberto
Benussi, Luisa
Bessi, Valentina
Binetti, Giuliano
Mead, Simon
Black, Sandra
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Mitchell, Sara
Cañada, Marta
Cantoni, Valentina
Caroppo, Paola
Castelo-Branco, Miguel
Convery, Rhian
Miltenberger-Miltenyi, Gabriel
Cope, Thomas
Di Fede, Giuseppe
Díez, Alina
Duro, Diana
Jelic, Vesna
Fenoglio, Chiara
Ferrari, Camilla
Ferreira, Catarina B.
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
van Minkelen, Rick
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Karnath, Hans-Otto
Gazzina, Stefano
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Hoegen, Tobias
Keren, Ron
Langheinrich, Tobias
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Tiraboschi, Pietro
Maruta, Carolina
Moore, Katrina
Nacmias, Benedetta
Nicholas, Jennifer
Öijerstedt, Linn
Olives, Jaume
Ourselin, Sebastien
Meeter, Lieke H.
Padovani, Alessandro
Pievani, Michela
Todd, Emily
Polito, Cristina
Premi, Enrico
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rittman, Tim
Dopper, Elise G. P.
Rogaeva, Ekaterina
Rosa-Neto, Pedro
Rossi, Giacomina
Rosser, Martin
Santiago, Beatriz
Scarpini, Elio
Schönecker, Sonja
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Bocchetta, Martina
Tábuas-Pereira, Miguel
Van Damme, Philip
Tainta, Mikel
Taipa, Ricardo
Tang-Wai, David
Thomas, David L.
Thompson, Paul
Thonberg, Hakan
Timberlake, Carolyn
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Arighi, Andrea
Woollacott, Ione
Wlasich, Elisabeth
Zulaica, Miren
Cash, David
Graff, Caroline
Synofzik, Matthis
Moreno, Fermin
Finger, Elizabeth
Sanchez-Valle, Raquel
Vandenberghe, Rik
Balasa, Mircea
Laforce, Robert
Masellis, Mario
Tartaglia, Maria Carmela
Rowe, James B.
Butler, Chris
Ducharme, Simon
Gerhard, Alexander
Danek, Adrian
Levin, Johannes
Pijnenburg, Yolande A. L.
Barandiaran, Myriam
Otto, Markus
Borroni, Barbara
Tagliavini, Fabrizio
De Mendonça, Alexandre
Santana, Isabel
Galimberti, Daniela
Sorbi, Sandro
Zetterberg, Henrik
Huang, Eric
van Swieten, John C.
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv van der Ende, Emma L.
Heller, Carolin
Sogorb-Esteve, Aitana
Swift, Imogen J.
McFall, David
Peakman, Georgia
Bouzigues, Arabella
Poos, Jackie M.
Jiskoot, Lize C.
Panman, Jessica L.
Papma, Janne M.
Bargalló, Nuria
Rohrer, Jonathan D.
Seelaar, Harro
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Archetti, Silvana
Bartha, Robart
Indakoetxea, Begoña
Bender, Benjamin
Benussi, Alberto
Benussi, Luisa
Bessi, Valentina
Binetti, Giuliano
Mead, Simon
Black, Sandra
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Mitchell, Sara
Cañada, Marta
Cantoni, Valentina
Caroppo, Paola
Castelo-Branco, Miguel
Convery, Rhian
Miltenberger-Miltenyi, Gabriel
Cope, Thomas
Di Fede, Giuseppe
Díez, Alina
Duro, Diana
Jelic, Vesna
Fenoglio, Chiara
Ferrari, Camilla
Ferreira, Catarina B.
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
van Minkelen, Rick
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Karnath, Hans-Otto
Gazzina, Stefano
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Hoegen, Tobias
Keren, Ron
Langheinrich, Tobias
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Tiraboschi, Pietro
Maruta, Carolina
Moore, Katrina
Nacmias, Benedetta
Nicholas, Jennifer
Öijerstedt, Linn
Olives, Jaume
Ourselin, Sebastien
Meeter, Lieke H.
Padovani, Alessandro
Pievani, Michela
Todd, Emily
Polito, Cristina
Premi, Enrico
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rittman, Tim
Dopper, Elise G. P.
Rogaeva, Ekaterina
Rosa-Neto, Pedro
Rossi, Giacomina
Rosser, Martin
Santiago, Beatriz
Scarpini, Elio
Schönecker, Sonja
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Bocchetta, Martina
Tábuas-Pereira, Miguel
Van Damme, Philip
Tainta, Mikel
Taipa, Ricardo
Tang-Wai, David
Thomas, David L.
Thompson, Paul
Thonberg, Hakan
Timberlake, Carolyn
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Arighi, Andrea
Woollacott, Ione
Wlasich, Elisabeth
Zulaica, Miren
Cash, David
Graff, Caroline
Synofzik, Matthis
Moreno, Fermin
Finger, Elizabeth
Sanchez-Valle, Raquel
Vandenberghe, Rik
Balasa, Mircea
Laforce, Robert
Masellis, Mario
Tartaglia, Maria Carmela
Rowe, James B.
Butler, Chris
Ducharme, Simon
Gerhard, Alexander
Danek, Adrian
Levin, Johannes
Pijnenburg, Yolande A. L.
Barandiaran, Myriam
Otto, Markus
Borroni, Barbara
Tagliavini, Fabrizio
De Mendonça, Alexandre
Santana, Isabel
Galimberti, Daniela
Sorbi, Sandro
Zetterberg, Henrik
Huang, Eric
van Swieten, John C.
dc.subject.por.fl_str_mv Biomarker
Complement
Frontotemporal dementia
Neuroinflammation
topic Biomarker
Complement
Frontotemporal dementia
Neuroinflammation
description © The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-09T14:42:57Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.relation.none.fl_str_mv 10.1186/s12974-022-02573-0
1742-2094
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